Analysis of VIP and CGRP Plasma Levels After Radiotherapy for Treatment of Metastasis from Prostatic Carcinoma

Abstract

A BSTRACT : It has previously been shown that radiotherapy leads to an increased level of neuropeptides in various organs. In the study we report here, we examined whether the plasma levels of two neuropeptides, vasoactive intestinal peptide (VIP) and calcitonin gene-related peptide (CGRP), are influenced by radiotherapy. Blood was collected at four time intervals after radiotherapy; 1-12 days after treatment for skeletal metastasis from prostatic carcinoma. The VIP-and CGRP-plasma levels, as analyzed by radioimmunoassay, were not statistically different between the different time points analyzed.