Villous adenoma of the urinary bladder: rare location

Abstract

Villous adenomas are common lesions of the gastrointestinal tract but they are rarely located in the urinary tract including the urinary bladder. There are a few case reports and series in the literature. Here we report a 43-year-old male patient who had a polypoid lesion located on the left lateral wall of the urinary bladder. Transurethral resection was performed. The diagnosis was ‘villous adenoma of urinary bladder’ with clinical and histopathological findings.Villous adenomas are mostly seen in elderly males. The coexistence of villous adenoma with adenocarcinoma, squamous cell carcinoma, and urothelial carcinoma was observed but there is not clear evidence about progression to carcinoma, in spite of its colonic counterpart. Generally complete surgical resection is accepted as curative but there are no exact data about follow-up and recurrence. By presenting this case, we aim to emphasize that it is a rare but important lesion because of coexistence with malignancies and uncertain malignant potential.

Cytopathological features of villous adenoma of the urinary bladder in urine: A rare case report

“…Atik et al hypothesized two theories as to why villous adenoma of the urinary bladder occurs. First, the embryological origins of distal colorectum and urinary bladder are closely related, and the remnants of cloaca may therefore exist in the bladder and cause a glandular epithelial neoplasm.…”

Villous Adenoma Coexisting with Non-Muscle Invasive Urothelial Carcinoma of the Bladder, Case Report

“…The most common site of its occurrence is the bladder dome and posterior wall, our case located on the dome of the bladder. The frequent complaints were hematuria, irritative symptoms and rarely mucusuria (2,3,4). Villous adenomas are rare in comparison to adenocarcinomas, with only fourteen individual cases having been reported so far.…”

“…There may be a similar spectrum of changes in the bladder, progressing from metaplasia in cystitis glandularis, to dysplasia in a villous adenoma, and eventually to malignant change in an adenocarcinoma. As so few cases have been reported, it is difficult to predict their behaviors, or assess their potential for malignant transformation (3,4,5,6,7). Once villous adenoma has been diagnosed, it is important to eliminate the presence of invasion.…”

“…In the latter, the epithelium is pseudostratified, and the nuclei are enlarged, crowded and hyperchromatic, features that are not present in cystitis glandularis (2,3,8,9,10). The coexistence of villous adenoma with in situ or invasive adenocarcinoma, squamous cell carcinoma, and urothelial carcinoma was reported in some studies (3,4). On the other hand, there is no clear evidence about progression to carcinoma, in spite of its colonic counterpart (1).…”

Villous adenoma arising in the urethra of a female with bladder augmentation history: a case report and review of the literature

“…They are frequently seen in elderly patients with a predilection for the urachus, dome and trigone of the bladder (1,4). Male predominance has been reported (1,2,5). VAs of the female urethra are very rare with only seven cases in the English literature to our knowledge (Table I) (1,(6)(7)(8)(9)(10)(11).…”