Vidalenolone, a Novel Phenolic Metabolite from the Tropical Red Alga <i>Vidalia </i>sp.

Yoo, Hye‐Dong; Ketchum, Sharon O.; France, Dennis S.; Bair, Ken; Gerwick, William H.

doi:10.1021/np010319c

Cited by 27 publications

(21 citation statements)

References 8 publications

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“…Liquiritigenin and 6-aldehydo-isoophiopogonone had been extracted earlier from Glycyrrhiza radixand Ophiopogon japonicas plants. Studies on these fractions reported Liquiritigenin and 6-aldehydo-isoophiopogononeto hold potent antioxidant, anti-allergic, anti-inflammatory, and anti-hyperlipidemic properties [49,50]. Likewise, Genistien-d 4 -an isoflavone and Vitexin -an epigenin flavone isolated from G. asiatica extracts had been reported to possess anti-inflammatory and anticancer properties against colon and breast cancer cells [51,52].Biological properties of G. asiatica fruit extracts reported in this study correlate with isolated bioactive compounds that had already been reported as potential antioxidant, anti-inflammatory and anti-cancerous agents.…”

Section: Identification Of Compounds By Lc-ms/msmentioning

confidence: 99%

Anticancer and anti-inflammatory perspectives of Pakistan’s indigenous berry Grewia asiatica Linn (Phalsa)

Qamar

Akhtar

Sestili

et al. 2020

JBR

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BACKGROUND: Berries indigenously grown in Asia are known for their diversified nutritional and health promoting properties. Establishing a link between berry consumption and their classical uses in health management however requires detailed research in exploring varied biochemical factors and their therapeutic role in averting risks of chronic disorders. OBJECTIVE: The present study was aimed at evaluating anti-inflammatory and anticancer responses of fruit extracts of Grewia asiatica locally known as Phalsa. METHODS: Dichloromethane, methanol and 50% hydro-methanolic fractions of fruit were evaluated for polyphenols characterization, quantification and antioxidant assays. Anti-inflammatory and anti-nociceptive responses of fruit extracts were evaluated in rats and mice models, respectively, and cytotoxic activities were measured against MCF-7, HeLa, HEp-2, NCI-H522, HEK-293 cancer cell cultures. RESULTS: Phenolics quantification and biological study data suggested 50% hydro-methanolic extracts as maximum carrier of flavonoids (7.92 mgQE/g), anthocyanins (8.1 mg/Kg) and tannins (187.2 mgGAE/g) that significantly (p < 0.05)resulted in higher oxidation inhibition (IC50 41.1 ug/ml), paw edema inhibition (68-74%) and pain mediation in neurogenic phase(31-62%) when administrated at the rate of 400 mg/kg b.w. Maximum cytotoxic activity of G. asiatica (50% hydromethanolic extracts) was observed against MCF-7 (IC50 34.9 ug/mL), HEp-2 (IC50 80.4 ug/mL) and NCI-H522 (IC50 73 ug/mL) cancer cell lines. LC-ESI-MS/MS characterization of hydro-alcoholic fractions bearing potent biological activities revealed Gallic acid, Ellagic acid, Quinic acid, Calycosin, Vidalenolone, Quercetin, Myricetin, Liquitrigenin and 6-aldehydo-isoophiopogonone. Human equivalent doses of the extracts calculated on the basis of total phenolic contents for anti-inflammatory and nociceptive assays were in range between 6.2-15.8 mg/kg b.w., and 3.1-7.9 mg/kg b.w., respectively.

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Section: Identification Of Compounds By Lc-ms/msmentioning

confidence: 99%

Anticancer and anti-inflammatory perspectives of Pakistan’s indigenous berry Grewia asiatica Linn (Phalsa)

Qamar

Akhtar

Sestili

et al. 2020

JBR

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“…A chemically synthesized novel phenolic metabolite, vidalenolone, as well as two previously described and structurally simple phenols were isolated as SH2-inactive substances. Their structures were determined by spectroscopic methods such as 2D NMR [67]. The cytotoxic activities of all the synthetic compounds were determined against DLD-1 cells using the MTT assay.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic application of natural inhibitors against snake venom phospholipase A2

Samy¹,

Gopalakrishnakone²,

Chow³

2012

Bioinformation

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Natural inhibitors occupy an important place in the potential to neutralize the toxic effects caused by snake venom proteins and enzymes. It has been well recognized for several years that animal sera, some of the plant and marine extracts are the most potent in neutralizing snake venom phospholipase A2 (svPLA2). The implication of this review to update the latest research work which has been accomplished with svPLA2 inhibitors from various natural sources like animal, marine organisms presents a compilation of research in this field over the past decade and revisiting the previous research report including those found in plants. In addition to that the bioactive compounds/inhibitor molecules from diverse sources like aristolochic alkaloid, flavonoids and neoflavonoids from plants, hydrocarbones 2, 4 dimethyl hexane, 2 methylnonane, and 2, 6 dimethyl heptane obtained from traditional medicinal plants Tragia involucrata (Euphorbiaceae) member of natural products involved for the inhibitory potential of phospholipase A2 (PLA2) enzymes in vitro and also decrease both oedema induced by snake venom as well as human synovial fluid PLA2. Besides marine natural products that inhibit PLA2 are manoalide and its derivatives such as scalaradial and related compounds, pseudopterosins and vidalols, tetracylne from synthetic chemicals etc. There is an overview of the role of PLA2 in inflammation that provides a rationale for seeking inhibitors of PLA2 as anti-inflammatory agents. However, more studies should be considered to evaluate antivenom efficiency of sera and other agents against a variety of snake venoms found in various parts of the world. The implications of these new groups of svPLA2 toxin inhibitors in the context of our current understanding of snake biology as well as in the development of new novel antivenoms therapeutics agents in the efficient treatment of snake envenomations are discussed.

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“…These metabolites have played an important role in leading to new pharmaceutical compounds for antitumor drugs (Luesch et al, 1999;Patterson et al, 1994;Yoo et al, 2002). Several representative antitumor compounds from algae, such as Halomon, had been developed to the clinical phase (Egorin et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Screening marine algae from China for their antitumor activities

Fan

Yan

et al. 2004

J Appl Phycol

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Thirty-nine species of marine algae collected from the coast of China were screened for their antitumor activities, and eight species Leathesia difformes, Polysiphonia urcedata, Scytosiphon lomentarius, Gloiopeliis furcata, Punctaria latifolia, Symphyocladia latiuscula, Rhodomela confervoides and Ulva pertusa showed potent cytotoxic activities. Three, Rhodomela confervoides, Scytosiphon lomentarius and Gloiopeliis furcata, were used for further investigation. More than 30 compounds were isolated and purified, and 14 bromophenols, 1 steroid and 1 carotene were identified by advanced spectroscopic methods including IR, MS, and NMR techniques. Amongst the 16 identified compounds, 7 showed vigorously selective activities against KB, Bel7402 and A549 cancer cells, and 6 bromophenols were new compounds.Abbreviations: IR, infrared spectroscopy; MS, mass spectroscopy; NMR, nuclear magnetic resonance.

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Vidalenolone, a Novel Phenolic Metabolite from the Tropical Red Alga Vidalia sp.

Cited by 27 publications

References 8 publications

Anticancer and anti-inflammatory perspectives of Pakistan’s indigenous berry Grewia asiatica Linn (Phalsa)

Anticancer and anti-inflammatory perspectives of Pakistan’s indigenous berry Grewia asiatica Linn (Phalsa)

Therapeutic application of natural inhibitors against snake venom phospholipase A2

Screening marine algae from China for their antitumor activities

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