Screening marine algae from China for their antitumor activities

Xu, Nianjun; Fan, Xiangtao; Yan, Xiaojun; Tseng, C. K.

doi:10.1007/s10811-004-5508-x

Cited by 64 publications

(38 citation statements)

References 20 publications

(20 reference statements)

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“…Studies on bioactivity of marine algae against cancer cell lines have been reported in previous researches, where the findings have brought great promise to the development of cancer treatment activities (Albano et al 1990;Berlinck et al 1996). Some studies involved general extractions of seaweeds while others applied extraction of specific metabolites such as carotene, bromophenols and carrageenan (Ly et al 2005;Xu et al 2004). In the present study, 90% methanolic extracts, 70% acetonic extracts and aqueous extracts of K. alvarezii and K. striatum were studied for their potential to inhibit the growth of HeLa cell lines.…”

Section: Discussionmentioning

confidence: 99%

Antiproliferative Potential of Extracts from Kappaphycus Seaweeds on HeLa Cancer Cell Lines

Tiek¹,

Vittal²,

Chew³

et al. 2014

JSM

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Section: Discussionmentioning

confidence: 99%

Antiproliferative Potential of Extracts from Kappaphycus Seaweeds on HeLa Cancer Cell Lines

Tiek¹,

Vittal²,

Chew³

et al. 2014

JSM

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“…Some metabolites such as bromophenols, carotene and steroids were isolated and purified in some algae and their activity against some cancer cell lines were demonstrated (Xu et al, 2004). Also, in another study, it was shown that the sulfated compounds such as fucoidans which were extracted from Sargassum polycystum and some other brown algae exhibited important roles against some human cancer cell lines (Ly et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Screening for in vitro Cytotoxic Activity of Seaweed, Sargassum sp. Against Hep-2 and MCF-7 Cancer Cell Lines

Mary

Vinotha²,

Pradeep³

2012

Asian Pacific Journal of Cancer Prevention

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Discovery of anticancer drugs that kill or disable tumor cells in the presence of normal cells without undue toxicity is a potential challenge for therapeutic care. Several papers in the literature have emphasized the potential implications of marine products such as seaweeds which exhibit antitumor activity. Study attempts to screen the antitumor effect of Sargassum sp, against chosen cell lines such as MCF-7 (Breast cancer) and Hep-2 (Liver Cancer). Ethanol extract of Sargassum sp. was concentrated using a Soxhlet apparatus and dissolved in DMSO. In vitro cytotoxic activity of Sargassum sp at various concentrations (100 µg/ml-300 µg/ml) screened for antitumor effect against the chosen cell lines using MTT assay (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide, a yellow tetrazole). The study documented that the percentage of cell viability has been reduced with increased concentration, as evidenced by cell death. Sargassum sp extract shows potential cytotoxic activity (P≤0.05) with IC 50 of 200 µg/ml and 250 µg/ml against Hep-2 and MCF-7 cell lines respectively. The ethanol fraction of Sargassum sp induced cell shrinkage, cell membrane blebbing and formation of apoptotic bodies with evidence of bioactive components as profound influencing factors for anti-tumor effects. Further research need to be explored for the successful application of Sargassum sp as a potent therapeutic tool against cancer.

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“…Marine algae have shown cytotoxic and antitumour nature [8,9]. Seaweed and their organic extracts exhibited cytotoxic activity which also showed in several literatures that highlighted the potential nature of marine products and in vitro, as well as in vivo anti-proliferative activity in human cancer cell lines [10,11].…”

Section: Introductionmentioning

confidence: 90%

In vitro cytotoxic studies of red algae Portieria hornemannii and Spyridia fusiformis against Dalton’s lymphoma ascite and Ehrlich ascite carcinoma cell lines

2016

J Coast Life Med

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Objective: To study the in vitro cytotoxic activities of methanol extract of Portieria hornemannii (P. hornemannii) and Spyridia fusiformis (S. fusiformis) using Dalton's lymphoma ascite and Ehrlich ascite carcinoma cell lines. Methods: The effect of cytotoxicity of P. hornemannii and S. fusiformis was evaluated with the concentrations (100 to 200 μg/mL) and assessed for the antitumour activity vs. the selected cell lines using Trypan blue assay. Results: The methanol extracts of P. hornemannii and S. fusiformis showed potent cytotoxic activity with IC 50 values of (209.00 ± 0.05) µg/mL and (190.00 ± 0.05) µg/mL against the Dalton's lymphoma ascite cell line and IC 50 values of (190.00 ± 0.05) µg/mL and (182.00 ± 0.05) µg/mL against the Ehrlich ascite carcinoma cell line respectively. In vitro cytotoxicity against the tested cancer cell lines showed strong activity by the abnormal activities of algal residue in the normal cells. Conclusions:The methanol solvent residue of red algae (P. hornemannii and S. fusiformis) could be a good candidate. It would be a novel marine resource as a antitumor medicine demonstrated by cytotoxic studies that the above marine algae can be a potential candidate sources as antitumor drugs Article history:

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Screening marine algae from China for their antitumor activities

Cited by 64 publications

References 20 publications

Antiproliferative Potential of Extracts from Kappaphycus Seaweeds on HeLa Cancer Cell Lines

Antiproliferative Potential of Extracts from Kappaphycus Seaweeds on HeLa Cancer Cell Lines

Screening for in vitro Cytotoxic Activity of Seaweed, Sargassum sp. Against Hep-2 and MCF-7 Cancer Cell Lines

In vitro cytotoxic studies of red algae Portieria hornemannii and Spyridia fusiformis against Dalton’s lymphoma ascite and Ehrlich ascite carcinoma cell lines

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