In vitro cytotoxic studies of red algae Portieria hornemannii and Spyridia fusiformis against Dalton’s lymphoma ascite and Ehrlich ascite carcinoma cell lines

Abstract

Objective: To study the in vitro cytotoxic activities of methanol extract of Portieria hornemannii (P. hornemannii) and Spyridia fusiformis (S. fusiformis) using Dalton's lymphoma ascite and Ehrlich ascite carcinoma cell lines. Methods: The effect of cytotoxicity of P. hornemannii and S. fusiformis was evaluated with the concentrations (100 to 200 μg/mL) and assessed for the antitumour activity vs. the selected cell lines using Trypan blue assay. Results: The methanol extracts of P. hornemannii and S. fusiformis showed potent cytotoxic activity with IC 50 values of (209.00 ± 0.05) µg/mL and (190.00 ± 0.05) µg/mL against the Dalton's lymphoma ascite cell line and IC 50 values of (190.00 ± 0.05) µg/mL and (182.00 ± 0.05) µg/mL against the Ehrlich ascite carcinoma cell line respectively. In vitro cytotoxicity against the tested cancer cell lines showed strong activity by the abnormal activities of algal residue in the normal cells. Conclusions:The methanol solvent residue of red algae (P. hornemannii and S. fusiformis) could be a good candidate. It would be a novel marine resource as a antitumor medicine demonstrated by cytotoxic studies that the above marine algae can be a potential candidate sources as antitumor drugs Article history: