Vibratory stimulation increases interleukin-1 beta secretion during orthodontic tooth movement

Leethanakul, Chidchanok; Suamphan, Sumit; Jitpukdeebodintra, Suwanna; Thongudomporn, Udom; Charoemratrote, Chairat

doi:10.2319/111914-830.1

Cited by 76 publications

(104 citation statements)

References 20 publications

(23 reference statements)

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“…In agreement with these findings Leethanakul et al found higher concentration of IL-1β in canines after electric toothbrush application for 2 months (16). Interestingly, in their study a higher rate of maxillary canine distalization was also reported.…”

Section: Discussionsupporting

confidence: 77%

“…Contrary to these findings, Pavlin et al (19) reported that low-level cycling loading of 0.25N at 30 Hz released by the same vibrational appliance used in the study of Miles et al increases the rate of orthodontic tooth movement (OTM) when applied as adjunct to orthodontic treatment. In a recent study Leethankul et al investigated through a split-mouth study the levels of IL-1β in gingival cervicular fluid and the rate of orthodontic tooth movement in canines stimulated by electric toothbrush compared to standard orthodontic movement of canines (16). They found enhanced secretion of IL-1β and accelerated OTM in canines stimulated by electric toothbrush vibrations.…”

Section: Ivyspring International Publishermentioning

confidence: 99%

“…On the other hand, an increase of bone mass could be induced by vibration of a certain frequency, intensity and duration (13). Based on promising results of few animal studies on potential acceleratory effects of vibrations, (12,14) several human studies were undertaken in order to evaluate the effect of vibrational forces on orthodontic tooth movement (11,(15)(16)(17)(18). However, contrasting results emerged by different studies.…”

Section: Ivyspring International Publishermentioning

confidence: 99%

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Aligning Effectiveness, Secretion of Interleukin 1β and Pain Control During Fixed Orthodontic Treatment with Self-Ligating Appliances and Supplemental Vibrational Appliances. A Randomized Controlled Clinical Trial

Kalemaj¹,

Buti²,

Deregibus³

et al. 2017

J. Biomed

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Aims: The aims of the present study were to investigate rate of mandibular incisors alignment, levels of IL-1β and pain and discomfort during orthodontic alignment with the following: 1) conventional-ligating appliance (CLA); 2) self-ligating appliance (SLA); 3) self-ligating appliance combined to vibrational appliance (SLA-VA). Methods: This was a three-armed parallel group randomized clinical trial with allocation ratio 1:1:1. The main inclusion criteria were: full permanent dentition, age below 25 years, no missing teeth, first skeletal and molar class, non-extraction treatment, Little's Irregularity Index (LII) from 3mm to 6mm. The main outcomes were rate of mandibular incisors alignment, concentration of IL-1β and pain and discomfort. Measurements on models were performed at appliance placement (t0) and at monthly intervals for the first 3 months (T1, T2, T3), whereas IL-1β levels were measured at weekly intervals for the first 3 weeks (t1, t2, t3). Differences between groups for normally-distributed variables were initially estimated through Analyses of Variance (ANOVAs) tests, followed by Post-Hoc Scheffe analysis for pair wise comparisons. Results: Thirty-three patients were recruited and randomized with no lost to follow-up. During the first two months, faster alignment was observed for SLA (P=0.0491) and SLA-VA (P=0.0134) compared to CLA. At each time-point of measurement no differences were observed between SLA and SLA-VA. At t1 and t2 were found higher values of IL-1β for SLA-VA compared to SLA (P=0.0209, P=0.0352) and CLA (P=0.0018, P=0.0029), whereas at t3 the difference persisted only versus CLA (P=0.0304). No relevant differences in terms of pain and discomfort were observed between groups at any time point. Conclusions: Self-ligating appliances seem to perform better than conventional-ligating appliances in terms of timing of teeth leveling and alignment. Vibrational devices seem to enhance secretion of IL-1β but do not increase effectiveness of leveling and alignment with regard to treatment acceleration or pain reduction.

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Section: Discussionsupporting

confidence: 77%

Section: Ivyspring International Publishermentioning

confidence: 99%

Section: Ivyspring International Publishermentioning

confidence: 99%

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Aligning Effectiveness, Secretion of Interleukin 1β and Pain Control During Fixed Orthodontic Treatment with Self-Ligating Appliances and Supplemental Vibrational Appliances. A Randomized Controlled Clinical Trial

Kalemaj¹,

Buti²,

Deregibus³

et al. 2017

J. Biomed

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“…21 The GCF absorbed on each paper point was diluted with 250 lL of sterile phosphate-buffered saline (pH 7.4), centrifuged (13,000 g at 48C for 15 minutes), and stored at À808C until analysis. 22 The Periotron was always calibrated before GCF sampling. 21 …”

Section: Cgf Samplingmentioning

confidence: 99%

Biochemical markers of bone metabolism during early orthodontic tooth movement with aligners

Castroflorio

Gamerro

Caviglia

et al. 2016

The Angle Orthodontist

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Objective: To evaluate the expression of receptor activator of nuclear factor-kappa ligand (RANKL), osteoprotegerin (OPG), osteopontin (OPN), interleukin 1b (IL-1b), and transforming growth factor ß1 (TGF-ß1) in the gingival crevicular fluid (GCF) of teeth subjected to orthodontic forces released by aligners. Materials and Methods: A total of 10 healthy, adult patients were selected to participate in this split-mouth study. The treatment plan was designed to obtain only one movement with the first aligner: distalization of a second molar. GCF samples were obtained from pressure and tension sites of the test tooth and from the mesiobuccal and distobuccal sites of the control tooth. The GCF sample volumes were measured using a Periotron 8000. Levels of TGF-b, IL-1b, RANKL, OPG, and OPN were measured by enzyme-linked immunosorbent assay. Results: IL-1b showed a significant increase at the pressure sites after 1 week and 3 weeks with respect to baseline (P , .05) compared with control sites. The kinetics of TGF-1b and OPN were characterized by a significant increase at the tension sites of the test teeth (P , .05) after 3 weeks from the application of orthodontic force. The RANKL level was significantly increased at pressure and tension sites after 1 hour and after 1 week from the application of the orthodontic forces (P ¼ .023 and P ¼ .043, respectively). Conclusions: An increased concentration of bone modeling and remodeling mediators at the pressure sites (IL-1b, RANKL) and tension sites (TGF-1b, OPN) was observed. These scenarios are compatible with previous in vivo and in vitro studies investigating the biological effects of orthodontic tooth movement. (Angle Orthod. 2017;87:74-81)

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“…The vibration tests were carried out for 5 minutes, and the resonance curves were displayed as frequency-force relationships on the monitor of the vibration controller. Clinical trials were conducted by various researchers [43][44][45][46][47] on human population using oral vibrating devices such as AccledentTM, AcceleDent® and electric tooth brushes and found to be effective in increasing the rate of tooth movement. Two cross sectional animal studies [43,44] done on cyclic vibration.…”

Section: Cyclic Vibrationsmentioning

confidence: 99%

Accelerated Orthodontics–An overview

Unnam¹,

Gs²,

P³

et al. 2018

J Dent Craniofac Res

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Orthodontic treatment is the reorganization of skeletal and/or dental tissues. Prolonged treatment duration is one of the main concerns of patients undergoing with fixed orthodontics. This extended orthodontic treatment in such particular cases has several drawbacks to the patients such as increased predisposition to root resorption, dental caries and gingival recession, etc. Consequently, researchers introduced few methods to accelerate the velocity of the tooth movement without any drawbacks. These kind of methods used in orthodontics were popular as accelerated orthodontics. Accelerated orthodontics could be possible by mechanical stimulation or device assisted therapy, surgical therapy and by the use of pharmacological agents. The purpose of the present manuscript was to describe and evaluate the methods used in accelerated orthodontics.Keywords: Accelerated orthodontics; Conventional orthodontic treatment; Corticotomy; Tooth movement IntroductionThe movement of tooth orthodontically happens under mechanical forces depends upon the alteration of the tissues surrounding its radicular part. These mechanical force creates a response in cellular component of surrounding periodontal ligament (PDL), that creates resorption in bone on pressure side and deposition of bone on the either side (tension side) [1]. This is an inflammatory process and the rate limiting factor for tooth movement is bone resorption at the bone and periodontal ligament interface [2]. Orthodontic movement can be controlled by the size of the applied force and the biological responses from the periodontal ligament [3]. This orthodontic force would cause inflammation around the periodontal ligament due to changes in blood flow, leading to the secretion of different inflammatory mediators like colony-stimulating factors, cytokines, growth factor, arachidonic acid metabolites and neurotransmitters. As a result of these secretions, remodelling of the bone occurs [4,5].Macrophage colony stimulating factor (M-CSF), Receptor activator of nuclear factor kappa B ligand (RANKL), and osteoprotegerin (OPG) by osteoblasts play key roles in tooth movement has been showed in Figure 1. RANKL binds to its receptor, RANK (Receptor activator of nuclear factor kappa B), on the surface of osteoclastic cells at developmental stage. The RANKL/RANK binding is very critical for the function, differentiation, and survival of osteoclasts. Fixed orthodontics could last for 24 to 36 months which further poses the risk of complications associated with the treatment such as external root resorption, periodontal problems and patient compliance. Orthodontists are persistently motivated towards developing potential strategies to enhance the rate of orthodontic tooth movement [6][7][8] AOTM has been preferred for its numerous prospective benefits like shorter treatment duration, differential tooth movement, enhanced envelope of tooth movement, improved post treatment stability and reduced side effects [9]. Attempts to AOTM can be dated back to the 1890s, where Cunningh...

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Vibratory stimulation increases interleukin-1 beta secretion during orthodontic tooth movement

Cited by 76 publications

References 20 publications

Aligning Effectiveness, Secretion of Interleukin 1β and Pain Control During Fixed Orthodontic Treatment with Self-Ligating Appliances and Supplemental Vibrational Appliances. A Randomized Controlled Clinical Trial

Aligning Effectiveness, Secretion of Interleukin 1β and Pain Control During Fixed Orthodontic Treatment with Self-Ligating Appliances and Supplemental Vibrational Appliances. A Randomized Controlled Clinical Trial

Biochemical markers of bone metabolism during early orthodontic tooth movement with aligners

Accelerated Orthodontics–An overview

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