Viability and electrophysiology of neural cell structures generated by the inkjet printing method

Xu, Tao; Gregory, Cassie; Molnár, Péter; Cui, Xiaofeng; Jalota, Sahil; Bhaduri, Sarit B.; Boland, Thomas

doi:10.1016/j.biomaterials.2006.01.048

Cited by 268 publications

(321 citation statements)

References 27 publications

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“…Xu et al used collagen and fibrin laden with primary embryonic hippocampal, cortical and NT2 neurons to fabricate 3D neural sheets. The neuronal phenotypes and electrophysiology of the printed construct were evaluated [111]. In the study by Hopp et al different cell types of SCs, astroglial cells and pig lens epithelial cells were deposited into gelatin.…”

Section: Bioprinting Of Neural Tissuesmentioning

confidence: 99%

3D bioprinting for cell culture and tissue fabrication

Jian

Wang

et al. 2018

Bio-des. Manuf.

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Three-dimensional (3D) bioprinting is a computer-assisted technology which precisely controls spatial position of biomaterials, growth factors and living cells, offering unprecedented possibility to bridge the gap between structurally mimic tissue constructs and functional tissues or organoids. We briefly focus on diverse bioinks used in the recent progresses of biofabrication and 3D bioprinting of various tissue architectures including blood vessel, bone, cartilage, skin, heart, liver and nerve systems. This paper provides readers a guideline with the conjunction between bioinks and the targeted tissue or organ types in structuration and final functionalization of these tissue analogues. The challenges and perspectives in 3D bioprinting field are also illustrated.

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Section: Bioprinting Of Neural Tissuesmentioning

confidence: 99%

3D bioprinting for cell culture and tissue fabrication

Jian

Wang

et al. 2018

Bio-des. Manuf.

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“…Inkjet cell printers were designed to use three general methods: thermal, piezoelectric, and acoustic inkjet printers using heat, piezoelectric, and acoustic wave actuators, respectively, to dispense cell-embedded microdroplets ( ) [23][24][25][26][27] . This technique is widely used for its high cell viability and resolution in microscale structures.…”

Section: Inkjet 3d Cell Printing Techniquementioning

confidence: 99%

Recent Cell Printing Systems for Tissue Engineering

Lee¹,

Koo²,

Yeo³

et al. 2017

Int. J. Bioprint.

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Three-dimensional (3D) printing in tissue engineering has been studied for the bio mimicry of the structures of human tissues and organs. Now it is being applied to 3D cell printing, which can position cells and biomaterials, such as growth factors, at desired positions in the 3D space. However, there are some challenges of 3D cell printing, such as cell damage during the printing process and the inability to produce a porous 3D shape owing to the embedding of cells in the hydrogel-based printing ink, which should be biocompatible, biodegradable, and non-toxic, etc. Therefore, researchers have been studying ways to balance or enhance the post-print cell viability and the print-ability of 3D cell printing technologies by accommodating several mechanical, electrical, and chemical based systems. In this mini-review, several common 3D cell printing methods and their modified applications are introduced for overcoming deficiencies of the cell printing process.

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“…For example, Xu et al studied the delivery of neuronal cells by a modified thermal inkjet printer, and demonstrated no significant effect on cell survival. [66,67] More recently, Lorber et al studied the potential of inkjet printing of adult rat retinal ganglion cells and retinal glia, demonstrating no significant difference in cell survival compared with non-printed controls. [68] In a similar approach, Tse et al printed primary porcine Schwann cells and neuronal analog NG108-15 cells with a piezoelectric inkjet printer.…”

Section: Bioprinting Technologiesmentioning

confidence: 99%

Three-dimensional neuronal cell culture: in pursuit of novel treatments for neurodegenerative disease

et al. 2017

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To gain a better understanding of the underlying mechanisms of neurological disease, relevant tissue models are imperative. Over the years, this realization has fuelled the development of novel tools and platforms, which aim at capturing in vivo complexity. One example is the field of biofabrication, which focuses on fabrication of three-dimensional (3D) biologically functional products in a controlled and automated manner. Herein, we provide a general overview of classical 3D cell culture platforms, particularly in the context of neurodegenerative disease. Subsequently, the focus is put on bioprinting-based biofabrication, its potential to advance 3D neuronal cell culture and, to conclude, the relevant translational bottlenecks, which will need to be considered as the field evolves.

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Viability and electrophysiology of neural cell structures generated by the inkjet printing method

Cited by 268 publications

References 27 publications

3D bioprinting for cell culture and tissue fabrication

3D bioprinting for cell culture and tissue fabrication

Recent Cell Printing Systems for Tissue Engineering

Three-dimensional neuronal cell culture: in pursuit of novel treatments for neurodegenerative disease

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