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To gain a better understanding of the underlying mechanisms of neurological disease, relevant tissue models are imperative. Over the years, this realization has fuelled the development of novel tools and platforms, which aim at capturing in vivo complexity. One example is the field of biofabrication, which focuses on fabrication of three-dimensional (3D) biologically functional products in a controlled and automated manner. Herein, we provide a general overview of classical 3D cell culture platforms, particularly in the context of neurodegenerative disease. Subsequently, the focus is put on bioprinting-based biofabrication, its potential to advance 3D neuronal cell culture and, to conclude, the relevant translational bottlenecks, which will need to be considered as the field evolves.

To bring novel biomaterials to clinical use, reliable in vitro models are imperative. The aim of this work was to develop a microfluidic tool to evaluate the biological properties of...

In article number https://doi.org/10.1002/adhm.201801181 by Zhilian Yue, Patrick T. Coates, Gordon G. Wallace, and co‐workers, a coaxial bioprinting platform is developed for fabrication of islet‐containing constructs. With precision control over the location of multiple cells, the coaxial printed constructs may provide protection to the encapsulated islets in the core while simultaneously delivering multiple supporting cells into the shell. This novel strategy has the potential to improve revascularization and provide immune‐protection to the implanted islets.

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