Veterinary drug residues determination in raw milk in Croatia

Bilandžić, Nina; Kolanović, Božica Solomun; Varenina, Ivana; Scortichini, Giampiero; Annunziata, Loredana; Brstilo, Matko; Rudan, Nevenka

doi:10.1016/j.foodcont.2011.05.007

Cited by 78 publications

(42 citation statements)

References 22 publications

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“…50 Na Croácia foram reportados os resultados de análise de resíduos de antibióticos em 1259 amostras de leite cru coletadas no período de 2008 a 2010. 120 Teste microbiológico detectou 36 amostras positivas, mas somente uma foi confirmada. Teste de imunoensaio mostrou uma amostra positiva para tetraciclinas, resultado confirmado por HPLC-DAD (1671 µg/L).…”

Section: Outros Paísesunclassified

Resíduos de medicamentos veterinários em leite e ovos

Pacheco-Silva¹,

Souza²,

Caldas³

2014

Quím. Nova

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VETERINARY DRUG RESIDUES IN MILK AND EGGS. The use of veterinary drugs in food producing animals may result in the presence of residues in foods, including milk and eggs. Immunoassay or microbiological tests are used to screen for residues, but chromatographic methods are needed to confirm positive results. In most methods, the sample is extracted with acetonitrile, submitted to clean up or directly analyzed by LC-MS/MS. Results of the Brazilian governmental monitoring programs from 2006 to 2011 have shown that the antiparasitic ivermectin was the drug most frequently found in milk. Residues in eggs are only monitored by one of the programs, and few studies have reported the incidence of veterinary drugs in this matrix in Brazil.Keywords: veterinary drugs; milk; eggs. INTRODUÇÃOMedicamentos são usados na medicina veterinária no tratamento e prevenção de doenças ou como promotores de crescimento. 1,2 Estes compostos compreendem uma variedade de classes químicas com ações terapêuticas diversas, incluindo antibiótica/antimicrobiana, antiparasitária, inseticida, fungicida e sedativa. 3 Os antimicrobianos (b-lactâmicos, aminoglicosídeos e tetraciclinas) e os antiparasitários (avermectinas, piretróides e organofosforados) são os produtos mais comercializados no Paraná para tratamento do rebanho leiteiro. 4 O uso de medicamentos veterinários em animais produtores de alimentos pode deixar resíduos nos alimentos, como carne, leite e ovos, cujos níveis não devem ultrapassar o Limite Máximo de Resíduos (LMR). O LMR é a concentração máxima de resíduo em um alimento de origem animal resultante do uso de um medicamento veterinário (expresso em mg/kg ou µg/kg, em peso fresco) que é recomendado para ser legalmente permitido ou reconhecido como sendo aceitável no alimento. 5 Estes limites são estabelecidos para garantir o uso adequado destes produtos, limitar a exposição e proteger a saúde dos consumidores dos alimentos provenientes de animais tratados. 5 A presença de resíduos em um alimento acima do LMR estabelecido indica que o produto não foi utilizado segundo as boas práticas de uso de medicamentos veterinários (BPMV), ou o uso de um produto não autorizado. 6 O Brasil não estabelece LMR para medicamentos veterinários, adotando aqueles recomendados pelo Mercosul, Codex Alimentarius, União Européia ou Estados Unidos. 7 A exposição humana a resíduos de medicamentos veterinários presentes nos alimentos pode causar efeitos adversos, incluindo reações alérgicas em indivíduos hipersensíveis 8 e câncer. 9,10 Adicionalmente, a exposição a antimicrobianos/antibióticos pode provocar o desenvolvimento de microrganismos resistentes, que dificulta a ação terapêutica destes medicamentos em indivíduos que consumiram alimentos de animais tratados. 11,12 Resíduos de medicamentos veterinários no leite podem também causar problemas tecnológicos nos processos de fermentação dos laticínios. 13,14 No Brasil, há dois programas nacionais que monitoram a presença de resíduos de medicamentos veterinários em produtos de origem animal. O Plano Nacional...

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Section: Outros Paísesunclassified

Resíduos de medicamentos veterinários em leite e ovos

Pacheco-Silva¹,

Souza²,

Caldas³

2014

Quím. Nova

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“…In these tests, chlortetracyclines, oxytetracyline, tetracycline, streptomycin, neomycin and erythromycin antibiotics had been detected [52]. In a study conducted in Croatia, 1259 raw milk samples were analyzed for antibiotic residue (chloramphenicol, penicillins, cephalosporins, tetracyclines, sulfonamides, beta-lactams, quinolones, aminoglycosides and macrolides) and 37 positive samples were found, but because of low levels it was stated that this would not cause any health problems [82]. The usage of chloramphenicol, which causes bone marrow suppression and aplastic anemia, is prohibited for animals.…”

Section: Veterinary Drug Residues In Conventional Animal Productsmentioning

confidence: 99%

Contaminants in Animal Products

Baydan¹,

Kanbur²,

Arslanbaş³

et al. 2017

Livestock Science

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Organic and conventional animal products may include residues of veterinary drugs and environmental contaminant. Food contaminants can cause consumer illness such as allergy, immunosuppression, cancer, teratogenicity, mutagenicity and genotoxicity. Therefore, their control is an important issue in terms of public health. In this article, information is given about contaminants such as bacterial, fungal, metal pesticides and veterinary drug that can be found in organic and conventional animal products. In addition, the effects of various cooking and freezing processes on contaminants in animal foods and their legal regulation have been mentioned.

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“…As milk is an essential food, the maximum residue levels (MRLs) for veterinary drugs are markedly lower in milk than in other food matrices, suggesting a larger consumption and recommendation for young children and older people (Bilandžić et al 2011). Furthermore, it is noteworthy that some veterinary drug residues are stable during storage, remain in the fermentation process and can become concentrated throughout the food chain (Whelan et al 2010), strengthening the importance of an investigation of veterinary drug residues in raw milk that is the initial vehicle for the whole milk food chain (Nebot et al 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Thus, in attempt to protect human health and ensure a high-quality product, several governmental authorities and international committees (Brasil 1999, European Commission 2010, FAO/WHO 2011 have set MRLs for various veterinary drug residues. Antimicrobials, macrocyclic lactones and pyrethroids are the most widely used veterinary drugs in dairy cattle management for disease therapy and control of bacterial and parasitic infections (Bilandžić et al 2011, Toaldo et al 2012. Therefore, most of these studies that have assessed the presence of veterinary drug residues in bulk tank milk in Brazil have used rapid screening methods (Cerqueira et al 2014, Trombete et al 2014 or analyzed a single or limited class of active compounds (Ciscato et al 2002, Hernandes et al 2009, Pacheco-Silva et al 2014.…”

Section: Introductionmentioning

confidence: 99%

Survey of pyrethroid, macrocyclic lactone and antibacterial residues in bulk milk tank from Minas Gerais State, Brazil

et al. 2017

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A survey of veterinary drug residues in bulk milk tank from Minas Gerais State, Brazil, was carried out through a broad scope analysis. Here, 132 raw milk samples were collected at 45 dairy farms in Minas Gerais from August 2009 to February 2010, and analyzed for 42 analytes, comprising pyrethroids, macrocyclic lactones and antibacterials, using liquid chromatography coupled with mass spectrometry in tandem mode and gas chromatography with electron capture detection. Within all milk samples, at least one veterinary drug residue was identified in 40 milk samples (30.30%) by confirmatory tests, whereas 16 samples (12.12%) showed the presence of at least two residues. With regard to the Brazilian maximum residue levels, 11 milk samples (8.33%) were non-compliant according to Brazilian Legislation. The veterinary drugs detected in the non-compliant milk samples include penicillin V (one sample), abamectin (one sample) and cypermethrin (nine samples). Furthermore, the antibacterial screening methods failed to identify most of the positive samples that were detected by confirmatory tests, leading to a large discrepancy between the screening and confirmatory antimicrobial tests. Thus, the present study indicated that the veterinary drugs residues still represents a great concern for the milk production chain.

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Veterinary drug residues determination in raw milk in Croatia

Cited by 78 publications

References 22 publications

Resíduos de medicamentos veterinários em leite e ovos

Resíduos de medicamentos veterinários em leite e ovos

Contaminants in Animal Products

Survey of pyrethroid, macrocyclic lactone and antibacterial residues in bulk milk tank from Minas Gerais State, Brazil

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