volume 8, issue 1, P16-30 2016
DOI: 10.18632/aging.100865
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Sylvia Weilner, Verena Keider, Melanie Winter, Eva Harreither, Benjamin Salzer, Florian Weiss, Elisabeth Schraml, Paul Messner, Peter Pietschmann, Florian Hildner, Christian Gabriel, Heinz Redl, Regina Grillari-Voglauer, Johannes Grillari et al.

Abstract: Aging results in a decline of physiological functions and in reduced repair capacities, in part due to impaired regenerative power of stem cells, influenced by the systemic environment. In particular osteogenic differentiation capacity (ODC) of mesenchymal stem cells (MSCs) has been shown to decrease with age, thereby contributing to reduced bone formation and an increased fracture risk.Searching for systemic factors that might contribute to this age related decline of regenerative capacity led us to investiga…

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