Involvement of extracellular vesicles in aging process and their beneficial effects in alleviating aging‐associated symptoms

Das, Madhurima; Kale, Vaijayanti

doi:10.1002/cbin.11691

Cited by 5 publications

(2 citation statements)

References 128 publications

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“…Hence, it is fair to propose that EVs may have a therapeutic role in age-related diseases. The role of EVs in the pathophysiology of these diseases, along with their potential use as biomarkers for these, has been reviewed before [ 116 , 117 , 118 ]. Here, we will focus on some of the most relevant studies using EVs as a therapeutic tool in age-related conditions.…”

Section: Therapeutic Potential Of Evs In Age-related Diseasesmentioning

confidence: 99%

Therapeutic Potential of Extracellular Vesicles in Aging and Age-Related Diseases

Sanz-Ros

Mas-Bargues

Romero-García

et al. 2022

IJMS

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Aging is associated with an alteration of intercellular communication. These changes in the extracellular environment contribute to the aging phenotype and have been linked to different aging-related diseases. Extracellular vesicles (EVs) are factors that mediate the transmission of signaling molecules between cells. In the aging field, these EVs have been shown to regulate important aging processes, such as oxidative stress or senescence, both in vivo and in vitro. EVs from healthy cells, particularly those coming from stem cells (SCs), have been described as potential effectors of the regenerative potential of SCs. Many studies with different animal models have shown promising results in the field of regenerative medicine. EVs are now viewed as a potential cell-free therapy for tissue damage and several diseases. Here we propose EVs as regulators of the aging process, with an important role in tissue regeneration and a raising therapy for age-related diseases.

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Section: Therapeutic Potential Of Evs In Age-related Diseasesmentioning

confidence: 99%

Therapeutic Potential of Extracellular Vesicles in Aging and Age-Related Diseases

Sanz-Ros

Mas-Bargues

Romero-García

et al. 2022

IJMS

View full text Add to dashboard Cite

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“…Mitochondria are the unique organelles of eukaryotes, which play an important role in maintaining homeostasis, such as metabolism, energy production, oxidative stress, and apoptosis ( 6 , 7 ). Osteoporosis is a prevalent aging-related disease, which is usually accompanied by changes in metabolic processes and mitochondrial dysfunction ( 8 , 9 ). And mitochondrial dysfunction will lead to the accumulation of reactive oxygen species (ROS) and induce the damage of various macromolecules such as proteins, nucleic acids, and lipids in cells ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

The Role of SIRT3 in the Osteoporosis

Wang

2022

Front. Endocrinol.

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SIRT3 is an NAD+-dependent deacetylase in the mitochondria with an extensive ability to regulate mitochondrial morphology and function. It has been reported that SIRT3 participates in the occurrence and development of many aging-related diseases. Osteoporosis is a common aging-related disease characterized by decreased bone mass and fragility fractures, which has caused a huge burden on society. Current research shows that SIRT3 is involved in the physiological processes of senescence of bone marrow mesenchymal stem cells (BMSCs), differentiation of BMSCs and osteoclasts. However, the specific effects and mechanisms of SIRT3 in osteoporosis are not clear. In the current review, we elaborated on the physiological functions of SIRT3, the cell types involved in bone remodeling, and the role of SIRT3 in osteoporosis. Furthermore, it also provided a theoretical basis for SIRT3 as a therapeutic target for osteoporosis.

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