Versuche zur Züchtung des Lymphogranuloma Inguinale-Virus

Meyer, Kurt H.; Anders, H. E.

doi:10.1007/bf01781485

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1933

2016

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Cited by 10 publications

(2 citation statements)

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“…Back in 1932, the so-called lymphogranuloma venereum (LGV) agent was first cultivated in Guinea pigs' kidney and testicles (16). The culture of clinical samples on cells monolayer (largely used the McCoy line, derived from mouse connective tissue) was for a longtime the gold standard (8) in Chlamydia diagnostics.…”

Section: Culturementioning

confidence: 99%

The microbiological diagnosis of Chlamydia trachomatis infections: milestones from a centenary history

Magliano¹

2016

Microbiol Med

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Section: Culturementioning

confidence: 99%

The microbiological diagnosis of Chlamydia trachomatis infections: milestones from a centenary history

Magliano¹

2016

Microbiol Med

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“…In 1932, Meyer and Anders (9) reported passage of the virus through 6 generations in cultures made of guinea pig kidney, testis and 25 per cent guinea pig serum in Tyrode's solution. The 6th passage produced an inguinal adenitis in only 10 of 20 guinea pigs and failed to give positive reactions when used as Frei antigen in human cases of lymphogranuloma.…”

mentioning

confidence: 99%

Studies on the Cultivation of the Virus of Lymphogranuloma Venereum

Sanders

1940

Journal of Experimental Medicine

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Two strains of the lymphogranuloma venereum virus were maintained in tissue cultures for 12 and 21 generations respectively. In a third strain a quantitative increase in potency as high as 1000 times was obtained by inoculating tissue cultures with infected emulsions of known virulence. Greater increases in potency were consistently obtained by maintaining tissue cultures and virus at room temperature (23°C. with a range of approximately ± 5°C.) than by incubating them at 37°C. The virus did not survive in the absence of oxygen. Embryonic guinea pig brain and serum ultrafiltrate were found to be the most effective vehicles for propagation of the lymphogranuloma virus. There is evidence that the site of activity for this virus is intracellular. Embryonic guinea pig brain cells were maintained in the serum ultrafiltrate diluted with buffered salt solution in good (morphologic) condition for as long as 70 days. Not only could old cultures be successfully inoculated with the virus of lymphogranuloma, but high titres could be maintained over extended periods.

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Miyagawanellen

Haagen¹

1964

Viruskrankheiten Des Menschen

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Versuche zur Züchtung des Lymphogranuloma Inguinale-Virus

Cited by 10 publications

References 1 publication

The microbiological diagnosis of Chlamydia trachomatis infections: milestones from a centenary history

The microbiological diagnosis of Chlamydia trachomatis infections: milestones from a centenary history

Studies on the Cultivation of the Virus of Lymphogranuloma Venereum

Miyagawanellen

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