Versuche über Pflanzen-Hybriden /

Mendel, Gregor

doi:10.5962/bhl.title.61004

Cited by 316 publications

(129 citation statements)

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“…In case of domestic animals the use of inbreeding combined with strict selection was successful (original idea by Festetics, 1819). Further contributions were the application the Mendelian rules of inheritance (Mendel, 1866), hybrid vigor (heterosis), as well as the natural dwarf mutants in wheat breeding (a major factor in the success of Green Revolution). Application of these methods led to a major rise in agricultural productivity that, in turn, resulted in a continuous decrease in food prices all over the world up until the beginning of the 21 st century (FAO, 2016).…”

Section: Introductionmentioning

confidence: 99%

Pathogenic potential and virulence genotypes of intestinal and faecal isolates of porcine post-weaning enteropathogenic Escherichia coli

Malik

Nagy

Kugler

et al. 2017

Research in Veterinary Science

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-This Minireview paper summarizes the views of the authors on the history and current status of golden rice -the highly promising concept of introducing new genes into existing rice strains to make them capable to accumulate beta carotene (the biochemical precursor of vitamin A) in the grain. Based on the questionable success of genetically modified organisms to achieve a significant increase in food and feed production we speculate on the possibility of a breakthrough in this area via the latest discoveries in molecular biological techniques.

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Section: Introductionmentioning

confidence: 99%

Pathogenic potential and virulence genotypes of intestinal and faecal isolates of porcine post-weaning enteropathogenic Escherichia coli

Malik

Nagy

Kugler

et al. 2017

Research in Veterinary Science

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“…1 Besides the genetic DNA code of a cell that is replicated faithfully upon every cell division and therefore virtually identical in every cell within an individual, 2 additional 'epigenetic' information fixes differential cell development by prompting daughter cells to express a similar set of genes as their mother cell. 3 This facilitates and thus preserves the differentiation process that the mother cell and its ancestors have undergone as part of cellular diversification within an organism.…”

mentioning

confidence: 99%

Cell division curtails helper phenotype plasticity and expedites helper T‐cell differentiation

Ham

Boer

2012

Immunol Cell Biol

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Following activation by antigen, helper T cells differentiate into one of many effector phenotypes. Formulating mechanistic mathematical models combining regulatory networks at the transcriptional, translational and epigenetic level, we study how individual helper T cells may adopt their different phenotypes. For each cytokine phenotype, for example, T helper type 1 (Th1) and type 2 (Th2) cells, we find that the intracellular molecular network allows a cell to adopt one of the three states, which we interpret as naive, active and memory states. Cell division markedly speeds up the differentiation into a particular memory state because of DNA demythelation. In a memory state, cells readily resume production of the same cytokine they produced before. Using stochastic models we show that helper T-cell plasticity (that is, the ability to switch phenotype) is low during clonal expansion. Although most memory cells rapidly secrete the original cytokine upon restimulation, some adopt another phenotype and produce different cytokines, allowing for considerable diversity in the phenotypes that are adopted during a memory response. In summary, we show that helper T-cell division expedites cell differentiation by increasing DNA demethylation. We also show that plasticity is low during the clonal expansion phase, but that helper T cells may adopt alternative phenotypes during a memory response. Keywords: epigenetic regulation; helper T-cell phenotypes; mathematical modelling; transcriptional regulation For more than a century, biologists have studied the mechanisms that enable cells to encode genetic information, and how this information is passed on to the cell's progeny. 1 Besides the genetic DNA code of a cell that is replicated faithfully upon every cell division and therefore virtually identical in every cell within an individual, 2 additional 'epigenetic' information fixes differential cell development by prompting daughter cells to express a similar set of genes as their mother cell. 3 This facilitates and thus preserves the differentiation process that the mother cell and its ancestors have undergone as part of cellular diversification within an organism.A variety of biological systems have now been studied using highthroughput technologies, which provide data that allow a better understanding of information processing within a cell. [4][5][6][7] The availability of quantitative data and the apparent complexity of cellular regulatory networks have led to a data-driven mathematical modelling approach that is usually referred to as computational or systems biology. Mathematical models have revealed nonlinearity in genetic networks that allow cells to switch between states. Examples are the Lac operon 8 and cells of the haematopoietic lineage. [9][10][11][12] Recently, epigenetic regulation mediated by histone modification has been studied using similar mathematical models. [13][14][15] At the molecular level these mathematical models describe quite different genetic and epigenetic systems. Mathematically they share im...

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“…Recently there has been considerable controversy about the interpretation of Mendel's "Versuche über PflanzenHybriden" [9] and its reinterpretation by the founders of genetics (see, e.g., [10][11][12][13][14][15]). In his paper Mendel used the words 'Factor(en)' twice and 'Elemente(n)' ten times, but clearly did not mean 'genes' by them.…”

Section: Early Attempts To Define and Delimit Genesmentioning

confidence: 99%

On the internal dynamics of mendelian genetics

Burian¹

2000

Comptes Rendus de l'Académie des Sciences - Series III - Scienc

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Versuche über Pflanzen-Hybriden /

Cited by 316 publications

References 0 publications

Pathogenic potential and virulence genotypes of intestinal and faecal isolates of porcine post-weaning enteropathogenic Escherichia coli

Pathogenic potential and virulence genotypes of intestinal and faecal isolates of porcine post-weaning enteropathogenic Escherichia coli

Cell division curtails helper phenotype plasticity and expedites helper T‐cell differentiation

On the internal dynamics of mendelian genetics

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