Vergleichende Untersuchungen �ber die Radio-Jodverteilung im Auge nach iontophoretischer und intraven�ser Verabreichung

Pommer, Horst; Trichtel, F.

doi:10.1007/bf00684767

Cited by 6 publications

(1 citation statement)

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“…Previous studies confirm that the lens (especially the lens core) shows the lowest iodide uptake among all ocular tissues and among all tested kinds of application [7,10,11].…”

Section: Discussionmentioning

confidence: 70%

Iodine Distribution in a Porcine Eye Model following Iontophoresis

Rieger

Winkler²,

Buchberger³

et al. 1995

Ophthalmologica

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Iodine distribution was studied in isolated porcine eyes after iontophoresis using ¹³¹l-labelled solutions and chemical methods. After a 15-min treatment with a therapeutically used iodine brine, the iodine content in the ocular tissues showed the following rank order: cornea > retina > vitreous body > anterior chamber fluid > lens. Replacement of the brine by 0.15 MNal increased the uptake values in a different way, but the same rank order was maintained. The increase was highest in the cornea (5.6-fold) and only about 2-fold in the lens, nevertheless approaching now the level of 10^––⁴ M, a concentration which was regarded as being optimal for the antioxidant effect of I^––. Among the other eye components, the relatively high iodine enrichment of the retina was remarkable. The data are discussed with respect to a possible protective, antioxidative and OH-scavenging efficacy of I and to previous results in the literature concerning iodine uptake in ocular tissues.

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“…Previous studies confirm that the lens (especially the lens core) shows the lowest iodide uptake among all ocular tissues and among all tested kinds of application [7,10,11].…”

Section: Discussionmentioning

confidence: 70%