Ventricular ependymoma in a German Shepherd dog

Vural, Sevil Atalay; Beşaltı, Ömer; İlhan, Fatma; Özak, Ahmet; Halıgür, Mehmet

doi:10.1016/j.tvjl.2005.02.014

Cited by 30 publications

(31 citation statements)

References 6 publications

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“…For human beings, this neoplasm commonly develops in the spinal cord and the fourth ventricle (Koestner and Higgins, 2002;Michimae et al, 2004;Vural et al, 2006); however, in the case of animals, the tumor mainly develops within the lateral ventricles, less often in third or fourth ventricle and rarely in the central canal of spinal cord (Koestner and Higgins, 2002). Regarding the pediatric cases, the location is usually intracranial; however, it is spinal for adults.…”

Section: Olgu Sunumumentioning

confidence: 99%

“…Among domestic animals, ependymomas are relatively rare tumors reported in a few cases including dogs, cats, cattle, horses, and rats (Carrigan et al, 1996;McGill and Wells, 1993;McKay et al, 1999;Michimae et al, 2004;Simpson et al, 1999;Vural et al, 2006). Ependymomas are occasionally reported in human infants; however, they are rarely observed in animals.…”

Section: Introductionmentioning

confidence: 99%

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Histopathological and immunohistochemical characteristics of ventricular ependymoma in a goat

Farjanikish¹,

Khodakaram-Tafti²

2016

İstanbul Üniversitesi Veteriner Fakültesi Dergisi

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Ependymomas as primary central nervous system neoplasms are occasionally observed in human infants however; they are rare in animals. A three-year-old male goat was presented with clinical neurological signs. At necropsy, a 3×2×2 cm, bulging, white-grey-to red, soft mass extending into the left lateral ventricle of brain was observed. Microscopically, the mass with densely cellular population was nonencapsulated, mostly containing cuboidal-columnar neoplastic cells with pseudo-rosettes formation. Mitotic figures were rare and malignancy indexes were not observed. Neoplastic cells were immunohistochemically positive for Glial Fibrillary Acidic Protein (GFAP), S-100, and vimentin; however, they did not express Cytokeratins. On the basis of the location, histologic and immunohistochemical findings, the tumor was diagnosed as an ependymoma.

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Section: Olgu Sunumumentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Histopathological and immunohistochemical characteristics of ventricular ependymoma in a goat

Farjanikish¹,

Khodakaram-Tafti²

2016

İstanbul Üniversitesi Veteriner Fakültesi Dergisi

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“…1,25 Canine ependymomas have been both immunohistochemically positive and negative for GFAP expression. 40 Most (67-100%) human ependymomas express GFAP. 2,17,21,36 Immunoreactivity in human tumors was strongest within cells of pseudorosettes closest to the vascular endothelium; expression in rosettes was more variable.…”

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confidence: 99%

Ventricular and Extraventricular Ependymal Tumors in 18 Cats

Woolford

Lahunta²,

Baiker

et al. 2012

Vet Pathol

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Ependymal tumors are reported rarely in domestic animals. The aims of this study were to examine the clinical and pathologic features of ventricular and extraventricular ependymomas and subependymomas in 18 domestic cats examined between 1978 and 2011. Parameters examined included age, sex, breed, clinical signs, and macroscopic and histopathologic features. The mean age of affected cats was 9 years, 4 months; median age, 8.5 years. There were 8 female and 4 male cats, and 6 cats for which sex was not recorded. Breeds included 10 domestic shorthaired, 2 domestic longhaired, 1 Persian, and 1 Siamese. Clinical signs included altered mentation or behavior, seizures, circling, propulsive gait, generalized discomfort, and loss of condition. The tumors often formed intraventricular masses and usually arose from the lining of the lateral or third ventricles, followed by the fourth ventricle, mesencephalic aqueduct, and spinal cord central canal. Three tumors were extraventricular, forming masses within the cerebrum and adjacent subarachnoid space. Histologically, 15 tumors were classified as variants of ependymomas (classic, papillary, tanycytic, or clear cell) and 3 as subependymomas. Tumors were generally well demarcated; however, 6 ependymomas focally or extensively infiltrated the adjacent neural parenchyma. Characteristic perivascular pseudorosettes were observed in all ependymomas; true rosettes were less common. Some tumors had areas of necrosis, mineralization, cholesterol clefts, and/or hemorrhage. This cohort study of feline ependymal tumors includes subependymoma and primary extraventricular ependymoma, variants not previously described in the veterinary literature but well recognized in humans.

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“…(1) Maulet et al 2008Wisner et al 2011Kraft et al 1997Vural et al 2006Yuh et al 2009Young et al 2011Snyder et al 2006Kraft et al 1997Kraft et Gavin 1999Rodenas et al 2009Kraft et al 1990 Ependymoma slightly " to slightly ! ; heterogeneity may be more pronounced when cysts or haemorrhage are present (2-5) moderately to markedly !…”

Section: Imagingmentioning

confidence: 99%

Magnetic resonance imaging of an equine ependymoma

Leser¹,

Flatz²,

Brühschwein³

et al. 2013

PHK

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SummaryA 16-year-old Warmblood gelding was presented with head tilt and a history of increasing numbers of seizures with alterations in consciousness. After each seizure the horse was depressed and quiet whereas before the episodes the gelding was restless, distracted and showed signs of discomfort (chewing, rolling its eyes). In the interictal period the horse was normal. Magnetic resonance imaging revealed a third ventricle mass and ventriculomegaly of the third and lateral ventricles. Histology of the mass was consistent with a well differentiated ependymoma. Keywords Signalment, History, Clinical findingsA 16-year-old warmblood gelding was presented with a 1-year history of progressive changes in mentation and recurrent paroxysmal collapse since 4 weeks. On clinical examination vital parameters were within physiological range (heart rate 40/min, respiratory rate 16/min). Superficial abrasions were evident on the horses` hind limbs. On neurological examination, the gelding was depressed. The horse showed a normal gait while it revealed slight proprioceptive deficits and delayed limb placement correction. Cutaneus trunci reflex and slap test were normal. The horse displayed a mild head tilt to the left with absence of pathological nystagmus. Evaluation of the cranial nerves bilaterally revealed mid-sized nonresponsive pupils. Hence, pupillary light reflex could not be elicited while vision was not impaired. Tongue tone and cervical reflexes were physiological. Examination of tail carriage, anal tone and anal reflex revealed no abnormalities. An intracranial disease was suspected with involvement of the midbrain and reticular activating system. Laboratory examination of blood revealed no abnormal findings. As the owner wanted the diagnostics and treatment to be cost restrictive an attempt was made to rule out infectious or inflammatory conditions by administering drugs. The horse showed no improvement upon treatment with systemic antibiotics, steroids and non-steroidal antiinflammatory drugs. The owner finally elected euthanasia and consented to extended postmortem examinations. ImagingA post-mortem Magnetic Resonance Imaging (MRI) of the neurocranium was performed immediately after euthanasia and cervical transection. All scans were performed with a 1.5 Tesla magnet (Magnetom Symphony, Siemens Medizintechnik, Erlangen, Germany) equipped with a spine coil and CP body array flex coil. The head and cervical spine were placed in left lateral recumbency. Images of the head and brain were acquired with T2-weighted turbo spin-echo (T2W) sequences in sagittal, dorsal and transverse planes (TR 8810 msec; TE 105). A T1-weighted 3D gradient-echo (T1W) sequence with multiplanar reconstruction images in sagittal orientation was acquired (TR 350; TE 17). Scans were accomplished by additional Fluid Attenuated Inversion Recovery (FLAIR; TR 9130; TE 127; TI 2500) and a T2*-weighted gradient echo sequence (T2*W; TR 1000; TE 28) in transverse plane. Dorsal, transverse and sagittal images of the cranial cervical spine (C1-C4) we...

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Ventricular ependymoma in a German Shepherd dog

Cited by 30 publications

References 6 publications

Histopathological and immunohistochemical characteristics of ventricular ependymoma in a goat

Histopathological and immunohistochemical characteristics of ventricular ependymoma in a goat

Ventricular and Extraventricular Ependymal Tumors in 18 Cats

Magnetic resonance imaging of an equine ependymoma

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