Ventral medial prefrontal cortex and cardiovagal control in conscious humans

Wong, Simon S.; Massé, Nicholas; Kimmerly, Derek S.; Menon, Ravi S.; Shoemaker, J. Kevin

doi:10.1016/j.neuroimage.2006.12.027

Cited by 203 publications

(209 citation statements)

References 71 publications

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“…This assertion is based on three principal considerations, including (a) the existence of inhibitory neural efferent pathways from the medial PFC to the PNS (the peripheral nervous system substrate of RSA), (b) positive associations between resting RSA and performance on executive function tasks, and (c) positive correlations between RSA and medial PFC activity in neuroimaging studies (see Beauchaine & Thayer, in press). Inhibitory neural efferent pathways from the medial PFC to the PNS have been reviewed by several authors (see, e.g., Barbas, Saha, Rempel-Clower, & Ghashghaei, 2003;Ter Horst & Postema, 1997;Wong, Masse, Kimmerly, Menon, & Shoemaker, 2007). As described by , the medial prefrontal, insular, and cingulate cortices form an interconnected network that exhibits feedback and feed-forward connections with the amygdala.…”

Section: Central Nervous System Substrates Of Rsamentioning

confidence: 99%

Future Directions in Emotion Dysregulation and Youth Psychopathology

Beauchaine

2015

Journal of Clinical Child & Adolescent Psychology

306

321

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Section: Central Nervous System Substrates Of Rsamentioning

confidence: 99%

Future Directions in Emotion Dysregulation and Youth Psychopathology

Beauchaine

2015

Journal of Clinical Child & Adolescent Psychology

306

321

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“…For completeness of reporting, however, we examined two other areas suggested by previous imaging studies to be involved in autonomic-cardiovascular control and reactivity: the insula and posterior cingulate (Critchley, 2005;Dalton et al, 2005;Gianaros et al, 2005;Wong et al, 2007). For these analyses, we created bilateral masks of each area with the WFU Pick Atlas, and we used Monte Carlo-determined thresholds ( p Ͻ 0.005, k values Ͼ 8) to maintain ROI false-positive detection rates at p Ͻ 0.05.…”

Section: Supplementary Analyses Of the Insula And Posterior Cingulatementioning

confidence: 99%

Individual Differences in Stressor-Evoked Blood Pressure Reactivity Vary with Activation, Volume, and Functional Connectivity of the Amygdala

Gianaros¹,

Sheu²,

Matthews³

et al. 2008

J. Neurosci.

244

222

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Individuals who exhibit exaggerated blood pressure reactions to psychological stressors are at risk for hypertension, ventricular hypertrophy, and premature atherosclerosis; however, the neural systems mediating exaggerated blood pressure reactivity and associated cardiovascular risk in humans remain poorly defined. Animal models indicate that the amygdala orchestrates stressor-evoked blood pressure reactions via reciprocal signaling with corticolimbic and brainstem cardiovascular-regulatory circuits. Based on these models, we used a multimodal neuroimaging approach to determine whether human individual differences in stressor-evoked blood pressure reactivity vary with amygdala activation, gray matter volume, and functional connectivity with corticolimbic and brainstem areas implicated in stressor processing and cardiovascular regulation. We monitored mean arterial pressure (MAP) and concurrent functional magnetic resonance imaging BOLD signal changes in healthy young individuals while they completed a Stroop color-word stressor task, validated previously in epidemiological studies of cardiovascular risk. Individuals exhibiting greater stressor-evoked MAP reactivity showed (1) greater amygdala activation, (2) lower amygdala gray matter volume, and (3) stronger positive functional connectivity between the amygdala and perigenual anterior cingulate cortex and brainstem pons. Individual differences in amygdala activation, gray matter volume, and functional connectivity with corticolimbic and brainstem circuits may partly underpin cardiovascular disease risk by impacting stressor-evoked blood pressure reactivity.

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“…An initial important observation of the current study was the difference in HR responses to IHG between the current participants and those of younger individuals reported earlier from our laboratory (Goswami et al 2012;Norton et al 2013;Wong et al 2007). This difference was statistically significant, as determined by an independent group's t-test that contrasted the present data with those published earlier.…”

Section: Discussionmentioning

confidence: 49%

“…Due to the abundance of neural activity, both corrections were performed sequentially, such that the final results represent only clusters Ͼ 10 voxels in size (unless otherwise specified). Based on earlier data in young individuals performing the same IHG protocol (Norton et al 2013;Wong et al 2007), an a priori region-of-interest analysis was performed for relevant cortical autonomic network regions including the bilateral insular cortices (IC), anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), thalamus, medial prefrontal cortex (MPFC), and hippocampus (HC). All fMRI data are represented in radiological convention (i.e., subject's right appears on the left).…”

Section: Participantsmentioning

confidence: 99%

“…Volitional isometric handgrip (IHG) contractions offer a unique opportunity to explore the cortical representation of autonomic cardiac control. More specifically, moderate-intensity IHG exercise of short duration produces a rapid tachycardia in young and healthy individuals (Mancia et al 1978;Mark et al 1985;Wong et al 2007) and pharmacological evidence indicates that a decrease in parasympathetic dominance accounts for much of this rapid HR change (Fagraeus and Linnarsson 1976;Hollander and Bouman 1975;Mitchell et al 1989). In young individuals, the magnitude of this rapid increase in HR with IHG exercise is correlated with reduced activity within the MPFC (Gianaros et al 2004;Wong et al 2007) and the HC (Norton et al 2013).…”

mentioning

confidence: 99%

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Coronary artery disease affects cortical circuitry associated with brain-heart integration during volitional exercise

Norton

Badrov

Barron

et al. 2015

Journal of Neurophysiology

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Norton KN, Badrov MB, Barron CC, Suskin N, Heinecke A, Shoemaker JK. Coronary artery disease affects cortical circuitry associated with brain-heart integration during volitional exercise. J Neurophysiol 114: 835-845, 2015. First published May 13, 2015 doi:10.1152/jn.00008.2015.-This study tested the hypothesis that coronary artery disease (CAD) alters the cortical circuitry associated with exercise. Observations of changes in heart rate (HR) and in cortical blood oxygenation level-dependent (BOLD) images were made in 23 control subjects [control; 8 women; 63 Ϯ 11 yr; mean arterial pressure (MAP): 90 Ϯ 9 mmHg] (mean Ϯ SD) and 17 similarly aged CAD patients (4 women; 59 Ϯ 9 yr; MAP: 87 Ϯ 10 mmHg). Four repeated bouts each of 30%, 40%, and 50% of maximal voluntary contraction (MVC) force (LAB session), and seven repeated bouts of isometric handgrip (IHG) at 40% MVC force (fMRI session), were performed, with each contraction lasting 20 s and separated by 40 s of rest. There was a main effect of group (P ϭ 0.03) on HR responses across all IHG intensities. Compared with control, CAD demonstrated less task-dependent deactivation in the posterior cingulate cortex and medial prefrontal cortex, and reduced activation in the right anterior insula, bilateral precentral cortex, and occipital lobe (P Ͻ 0.05). When correlated with HR, CAD demonstrated reduced activation in the bilateral insula and posterior cingulate cortex, and reduced deactivation in the dorsal anterior cingulate cortex, and bilateral precentral cortex (P Ͻ 0.05). The increased variability in expected autonomic regions and decrease in total cortical activation in response to the IHG task are associated with a diminished HR response to volitional effort in CAD. Therefore, relative to similarly aged and healthy individuals, CAD impairs the heart rate response and modifies the cortical patterns associated with cardiovascular control during IHG.

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Ventral medial prefrontal cortex and cardiovagal control in conscious humans

Cited by 203 publications

References 71 publications

Future Directions in Emotion Dysregulation and Youth Psychopathology

Future Directions in Emotion Dysregulation and Youth Psychopathology

Individual Differences in Stressor-Evoked Blood Pressure Reactivity Vary with Activation, Volume, and Functional Connectivity of the Amygdala

Coronary artery disease affects cortical circuitry associated with brain-heart integration during volitional exercise

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