Future Directions in Emotion Dysregulation and Youth Psychopathology

Beauchaine, Theodore P.

doi:10.1080/15374416.2015.1038827

Cited by 296 publications

(337 citation statements)

References 204 publications

(237 reference statements)

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“…A range of region-level brain targets have been implicated in self-regulation, which may function as components of one or more interconnected circuits or networks (Beauchaine, 2015; Braver, 2012; George & Koob, 2010; Helfinstein et al, 2013; Ochsner & Gross, 2008; Posner & Rothbart, 1998; Stoeckel et al, 2017). Biologically-based interventions targeting these networks include pharmacological interventions, neurofeedback, Transcranial Magnetic Stimulation, and Deep Brain Stimulation.…”

Section: The Sobc Target Classesmentioning

confidence: 99%

The NIH Science of Behavior Change Program: Transforming the science through a focus on mechanisms of change

Nielsen

Riddle

King

et al. 2018

Behaviour Research and Therapy

335

249

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The goal of the NIH Science of Behavior Change (SOBC) Common Fund Program is to provide the basis for an experimental medicine approach to behavior change that focuses on identifying and measuring the mechanisms that underlie behavioral patterns we are trying to change. This paper frames the development of the program within a discussion of the substantial disease burden in the U.S. attributable to behavioral factors, and details our strategies for breaking down the disease- and condition-focused silos in the behavior change field to accelerate discovery and translation. These principles serve as the foundation for our vision for a unified science of behavior change at the NIH and in the broader research community.

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Section: The Sobc Target Classesmentioning

confidence: 99%

The NIH Science of Behavior Change Program: Transforming the science through a focus on mechanisms of change

Nielsen

Riddle

King

et al. 2018

Behaviour Research and Therapy

335

249

View full text Add to dashboard Cite

show abstract

“…The vagus nerve is the primary nerve of the PNS and a major inhibitory pathway adaptively regulating inflammatory, immune, endocrine, and cardiovascular function (Thayer and Sternberg, 2006; Thayer and Lane, 2009; Jarczok et al , 2014). RVA, indexed by time- or frequency-domain measures of heart rate variability (HRV) reflecting fast parasympathetic modulation of autonomic control of the heart, is inversely related to affective instability in daily life (Koval et al , 2013), self-reports on difficulties in emotion regulation (Berna et al , 2014; Beauchaine, 2015; Williams et al , 2015) and depression severity in adults (Kemp et al , 2010). Functional neuroimaging studies and human lesion studies have shown several fronto-limbic brain regions and networks involved in the neural control of RVA (Thayer et al , 2012).…”

Section: Introductionmentioning

confidence: 99%

Brain structural thickness and resting state autonomic function in adolescents with major depression

Koenig

Schreiner

Klimes‐Dougan

et al. 2018

Social Cognitive and Affective Neuroscience

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Major depressive disorder (MDD) has been associated with abnormalities in cortical thickness and autonomic function. Adolescence is a time notable for brain development and MDD onset. In healthy adolescents, greater resting state vagal activity (RVA) is associated with lower cortical thickness. The relationship between brain structural thickness and RVA in adolescents with MDD has not previously been studied. This secondary analysis drew on a sample of 37 non-depressed controls and 53 adolescents with MDD. Resting state heart rate and two indices of RVA (HF-HRV and RMSSD) were recorded during a neuroimaging session. Cortical thickness within fronto-limbic regions of interest was measured using Freesurfer analysis of T1-weighted high-resolution structural images. Self-reports of depression severity showed a significant interaction with cortical thickness of the right insula in predicting RMSSD [t = 2.22, P=0.030, β = 5.44; model fit of the interaction term as indicated by the ‘Bayes Factor’ (BF): 7.58] and HF-HRV (t = 2.09, P=0.041, β = 4.72; BF: 7.94). Clinician ratings of depression severity showed further interactions. Findings underscore the important relationships between RVA and cortical development, suggesting two possible explanations: (i) in adolescent MDD, greater fronto-limbic thickness is compensatory for deficits in autonomic regulation or (ii) increased autonomic arousal results in delayed fronto-limbic maturation. Longitudinal research is necessary to further clarify the nature of the relationship between autonomic functioning and cortical development.

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“…RSA reactivity also appeared to converge around moderate RSA withdrawal for children with both high and low pretreatment resting RSA. Most previous speculations have considered RSA withdrawal (negative RSA reactivity) as the more adaptive physiological response to stress, but those have been limited mostly to cross-sectional studies and there is also evidence that excessive RSA withdrawal is associated with symptoms of both internalizing and externalizing psychopathology (Beauchaine 2015), which are both highly comorbid with PTSD (Saigh et al 2002). Comorbid internalizing and externalizing symptoms predict greater RSA withdrawal to emotion evocation tasks than either internalizing or externalizing alone (Calkins et al 2007; Pang and Beauchaine 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Blunted RSA withdrawal or an increase in RSA (RSA augmentation) in response to stressful contexts may indicate a maladaptive response associated with poor outcomes. However, there is also evidence that excessive RSA withdrawal in response to emotion evocation tasks is associated with increased internalizing and externalizing symptoms in children (Beauchaine 2015). These RSA patterns may change following interventions such as CBT.…”

Section: Introductionmentioning

confidence: 99%

Respiratory Sinus Arrhythmia in Cognitive Behavioral Therapy for Posttraumatic Stress Symptoms in Children: Preliminary Treatment and Gender Effects

Lipschutz

Gray

Weems

et al. 2017

Appl Psychophysiol Biofeedback

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Cognitive behavioral therapy (CBT) is an efficacious treatment for posttraumatic stress disorder (PTSD) symptoms, but the effect of CBT on physiological indicators is largely unknown. Respiratory sinus arrhythmia (RSA) is an established parasympathetic marker of self-regulatory capacity and stress responsivity. The present study tested if and how resting RSA and RSA reactivity changed following treatment among a sample of children (n= 48) who experienced at least one traumatic event and presented with PTSD symptoms. RSA reactivity was measured in response to personalized trauma-related scripts. Results indicated that changes in RSA after treatment were dependent on pretreatment resting levels of RSA, with individuals with high and low pretreatment resting RSA levels appearing to converge over time in both resting RSA and RSA reactivity by the 3-month follow up. Specific to RSA reactivity, a sex difference was evident, as following treatment, females showed less RSA withdrawal whereas males showed more RSA withdrawal. PTSD symptoms were significantly reduced after CBT but symptom change was not associated with pretreatment resting RSA levels. Overall, these results suggest that there may be multiple physiological patterns within children with PTSD and the direction of the physiological changes after CBT may depend on initial differences in resting RSA levels.

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Future Directions in Emotion Dysregulation and Youth Psychopathology

Cited by 296 publications

References 204 publications

The NIH Science of Behavior Change Program: Transforming the science through a focus on mechanisms of change

The NIH Science of Behavior Change Program: Transforming the science through a focus on mechanisms of change

Brain structural thickness and resting state autonomic function in adolescents with major depression

Respiratory Sinus Arrhythmia in Cognitive Behavioral Therapy for Posttraumatic Stress Symptoms in Children: Preliminary Treatment and Gender Effects

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