Venous thromboembolism in pregnancy and the puerperium: incidence and additional risk factors from a London perinatal database

Simpson, Erroll T.; Lawrenson, R; Nightingale, Alison; Farmer, Richard

doi:10.1111/j.1471-0528.2001.00004.x

Cited by 162 publications

(88 citation statements)

References 17 publications

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“…While pregnancies have a higher risk of venous thrombosis than non-pregnant women of matched age [2]. The incidence appears to be increased in the postpartum period [3]. The possible increased risk of recurrent pregnancy loss or deep vein thrombosis can be classified as acquired or genetic risk factors, when genetic defects are combined with one or more acquired risk factors it results in a risk of DVT that exceeds the separate effects of a single factor [4].…”

Section: Introductionmentioning

confidence: 99%

Frequency of Thrombophilic Gene Mutations in Patients with Deep Vein Thrombosis and in Women with Recurrent Pregnancy Loss

et al. 2017

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Thrombophilia may be anticipated by single or combined hereditary defects in encoding genes factor V, Prothrombin, and MTHFR. The aim of this study was to determine the prevalence and associated risks of V Leiden (G1691A), Prothrombin (G20210A), and MTHFR (C677T) mutations in Saudi women with Deep Vein Thrombosis (DVT) and women with recurrent pregnancy loss (RPL). Protein C and protein S activity were measured to determine combined effects, if any. We examined 60 women with a history of DVT and 60 with RPL, extracted DNA from EDTA blood and determined three mutations by using multiplex PCR reactions followed by Strip Assay KIT. Pro C Global assay was used to determine the cutoff value [PCAT-NR = 0.80]. Protein C/S chromogenic assay was used to estimate protein C and S percentages. Frequency of Factor V Leiden G/A genotype in patients with DVT 7 (11.6%) had a significant association for DVT χ2 (OR = 5.1, P = 0.03). In women with RPL the three mutations did not show any significant association, levels of Protein C, protein S and PCAT-NR in patient groups not different from controls (P > 0.05). In conclusion, we recommend expanding on these data to provide larger-scale studies.

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Section: Introductionmentioning

confidence: 99%

Frequency of Thrombophilic Gene Mutations in Patients with Deep Vein Thrombosis and in Women with Recurrent Pregnancy Loss

et al. 2017

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“…The risk might have been significantly underestimated in our study as we only identified clinically significant DVT and did not investigate the prevalence of DVT in the puerperium period, which is reported to be several times higher than that of the antenatal period (Andersen et al, 1998;Simpson et al, 2001). …”

Section: Masamitsu Yanadamentioning

confidence: 81%

Effect of haematological improvement on survival in patients given targeted therapy as initial treatment of acute myeloid leukaemia or high‐risk myelodysplastic syndrome

et al. 2007

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“…Our results were in agreement with previous reports as there were approximately twice and fi ve times as many postpartum as antepartum DVT events. 4,5 In contrast, James and colleagues reported more pregnant women suffer DVT in early pregnancy than in the puerperium. 6 In a meta-analysis, it was reported that about 82% of DVT occurred in the left lower extremity.…”

Section: Discussionmentioning

confidence: 94%

“…9 Yet blood group A, multiple pregnancy, caesarean section, cardiac disease, preterm delivery, high body mass index and elder women (Ͼ35 years) were found to increase incidence of VTE. 4 The association of blood group with DVT could explore the genetic predisposition (Factor V Leiden) of these groups to DVT. Although, we failed to observe an association between blood group and DVT, but those women who had family history of DVT were at higher risk of DVT.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of deep venous thrombosis during pregnancy and puerperium in Sudanese women

Gader

Haggaz²,

Adam³

2008

VHRM

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Background: Deep venous thrombosis (DVT) and venous thromboembolism (VTE) is a major health problem with high mortality worldwide. Patients at risk must be identifi ed and given appropriate prophylaxis in order to decrease the mortality. Objective: To investigate the prevalence of DVT in pregnancy and the puerperium and to identify risk factors for DVT. Setting: Khartoum and Khartoum North Teaching hospitals, Sudan. Design: Case-control study. Results: During the study period (April 2007-March 2008, 65 patients presented with DVT as confi rmed by Doppler ultrasound. A total of 14,490 deliveries occurred during the study period. The rate was 448 DVT per 100,000 births/year. Only four of these 65 patients were pregnant and the rest presented at postpartum. DVT occurred in the left lower extremity in 51 (78.4%), in the right in 13 (20.0%), and in one (1.5%) woman in both legs. In univarite and multivariate analyses, family history of DVT, primigravidae and cesarean section deliveries showed an higher risk of DVT. Conclusions:The study showed a high prevalence of DVT, most of these events occurred in the postpartum period. Primiparae, family history of DVT and cesarean section deliveries were important risk factors and these groups are candidate for prophylaxis measures against DVT.

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Venous thromboembolism in pregnancy and the puerperium: incidence and additional risk factors from a London perinatal database

Abstract: Objective To determine the incidence of venous thromboembolism in pregnancy and the puerperium and to identify risk factors for pregnancy-related venous thromboembolism.

Cited by 162 publications

References 17 publications

Frequency of Thrombophilic Gene Mutations in Patients with Deep Vein Thrombosis and in Women with Recurrent Pregnancy Loss

Frequency of Thrombophilic Gene Mutations in Patients with Deep Vein Thrombosis and in Women with Recurrent Pregnancy Loss

Effect of haematological improvement on survival in patients given targeted therapy as initial treatment of acute myeloid leukaemia or high‐risk myelodysplastic syndrome

Epidemiology of deep venous thrombosis during pregnancy and puerperium in Sudanese women

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