Epidemiology of deep venous thrombosis during pregnancy and puerperium in Sudanese women

Gader, Asha A; Haggaz, Abed Elrahium D; Adam, Ishag

doi:10.2147/vhrm.s4196

Cited by 19 publications

(4 citation statements)

References 11 publications

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“…In our study, median parity of the women was 2 and majority 261(67.8%) were having parity ≤2. In contrast, Gader AA et al observed in their study that primigravida females were at higher risk of developing DVT (p=0.01) 9 .…”

Section: Methodsmentioning

confidence: 72%

Risk Factors for Deep Vein Thrombosis in Pregnancy and Puerperium at a Tertiary Care Hospital in Muzaffarabad, AJK

Hafiz¹,

Nazir²,

Hussain³

et al. 2021

PJMHS

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Aim: Risk factors of deep vein thrombosis in pregnancy and puerperium in our setting. Study Design: Descriptive Cross-sectional study Place and duration of study: Departments of Obs & Gynae and General Medicine, CMH Muzaffarabad, AJK from 20th December, 2019 to 20th June, 2020. Methodology: A total of 385 females were included. Demographic data including age, parity, gravidity, BMI, obesity and timing of DVT occurrence was noted. The associated risk factors including mode of delivery in postpartum women, smoking status, past history of DVT, gestational diabetes and Diabetes Mellitus were noted. Results: Mean age of the participants was 26.1±5.3 years. Frequency of women developing deep vein thrombosis during pregnancy was 84.9% and 15.1% women developed DVT during puerperium. Past history of DVT was present in 26.5%. 31.7% of women were known diabetics and 29.1% developed gestational diabetes during current pregnancy. Frequency of smoking was 4.2%. 8% women presented with DVT in first trimester, 139(36.1%) in second trimester and 154 (40%) in third trimester. Conclusion: DVT is more common in the third trimester of pregnancy than in puerperium. Obesity, Diabetes Mellitus and past history of DVT were significant risk factors identified in the study. Keywords: Pregnancy, Postpartum Period, Deep Vein Thrombosis

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Section: Methodsmentioning

confidence: 72%

Risk Factors for Deep Vein Thrombosis in Pregnancy and Puerperium at a Tertiary Care Hospital in Muzaffarabad, AJK

Hafiz¹,

Nazir²,

Hussain³

et al. 2021

PJMHS

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“…21 Traditionally, African ethnicity has been associated with a higher prevalence of VTE of 4.48 per 1000 hospital deliveries. 22 In contrast, the prevalence of VTE ranges from 1.7 to 2 per 1000 deliveries in pregnant women of white and Asian ethnicity. 3 Nonetheless, only a few studies have examined the associations in African populations.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy‐related venous thromboembolism and HIV infection

Schapkaitz

Libhaber

Rhemtula

et al. 2021

Intl J Gynecology & Obste

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Objective To assess risk factors for venous thromboembolism (VTE) in African women in order to guide thromboprophylaxis. Methods A case‐control study was performed at a specialist obstetric unit in South Africa from July 1, 2017 to June 30, 2020. We identified 128 cases with VTE and 640 controls, matched for gestation. Results Prepartum risk factors associated with VTE included; medical comorbidities (odds ratios [OR] 5.32, 95% confidence intervals [CI] 1.82–15.56), human immunodeficiency virus (HIV) (OR 2.84, 95% CI 1.50–5.41), and hospital admission or immobility (OR 5.33, 95% CI 1.17–24.22). Postpartum, the following were identified as significant risk factors; medical comorbidities (OR 23.72, 95% CI 8.75–64.27), hospital admission or immobility (OR 13.18, 95% CI 5.04–34.49), systemic infection (OR 4.48, 95% CI 1.28–15.68), HIV (OR 3.20, 95% CI 1.49–6.87), pre‐eclampsia and fetal growth restriction (OR 2.74, 95% CI 1.18–6.36), and postpartum hemorrhage (OR 4.38, 95% CI 1.75–10.97). Antiretroviral therapy, opportunistic infections, and viral load >50 copies/ml, however, were not associated with VTE risk among HIV‐infected participants. Conclusion HIV was a significant risk factor for pregnancy‐related thrombosis. This was independent of traditional HIV risk factors. As such, future studies are recommended to explore the mechanisms of thrombosis associated with HIV infection.

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“…Normal venous velocities typically return between weeks 6 and 8 postpartum [31]. 82% of pregnant and postpartum women with DVT have it in their left lower extremity [32]. Possible anatomical causes could be the presence of the right common iliac artery exerting pressure on the left common iliac vein has been observed, which is made worse by the expanding uterus [33].…”

Section: Coagulation Systemmentioning

confidence: 99%

Elevated factor VIII level: An implication for thrombosis during pregnancy

Chikamso Favour Agbo,

Freedom Amarachi Nkwocha,

Reuben Chukwuma Odo

et al. 2023

Open Access Res. J. Life Sci.

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Hemostasis is the process by which the body maintains the integrity of blood vessels and regulates blood circulation. It involves arresting bleeding, and possibly mending broken or severed blood vessels. It is achieved through a series of steps, including vascular spasm, platelet plug formation, coagulation cascade, and fibrinolysis. Skipping any of these steps causes severe bleeding and death. During pregnancy, the hemostatic system undergoes significant changes to adapt to the physiological demands. These changes aim to prevent excessive bleeding during and after childbirth. Hypercoagulability, characterized by elevated clotting factors and reduced fibrinolytic activity, is common during pregnancy. While these alterations in the coagulation system help prevent postpartum bleeding, they also increase the mother's risk of thrombosis by a factor of five. This hypercoagulable state is caused by pregnancy-related factors like venous stasis, endothelial damage, and hormonal fluctuations. However, studies have shown that an increase in Factor VIII levels poses as a risk factor for both venous and arterial thrombosis. The determination of plasma factor VIII levels is influenced by genetic factors, as well as the levels of von Willebrand factor (VWF) and the individual's blood group. The findings of familial investigations have revealed that the concentration of factor VIII is indeed hereditary, exhibiting a lesser degree of variability among twins when compared with individuals who lack a familial connection. Continuous monitoring should be performed on pregnant patients with thrombosis risk factors. This intervention is implemented with the aim of mitigating the potential aggravation of deep vein thrombosis (DVT) and the subsequent development of post-thrombotic syndrome.

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Epidemiology of deep venous thrombosis during pregnancy and puerperium in Sudanese women

Cited by 19 publications

References 11 publications

Risk Factors for Deep Vein Thrombosis in Pregnancy and Puerperium at a Tertiary Care Hospital in Muzaffarabad, AJK

Risk Factors for Deep Vein Thrombosis in Pregnancy and Puerperium at a Tertiary Care Hospital in Muzaffarabad, AJK

Pregnancy‐related venous thromboembolism and HIV infection

Elevated factor VIII level: An implication for thrombosis during pregnancy

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