VEGF, PIGF and HIF-1α in placentas of early- and late-onset pre-eclamptic patients

Abstract

The results of the study indicated that there is no relationship between the time of onset of pre-eclampsia and the placental changes that occur in these factors.

Comparison of maternal and umbilical cord blood HIF-1α and nitric oxide levels in early and late onset preeclamptic pregnancies

“…HIF-1a and HIF-2a protein levels were found significantly higher in preeclamptic placentas [14,15]. In our previous study, we had observed higher levels of HIF-1a in both early and late onset preeclamptic placentas than normal controls, similar to findings of other previous published studies [16]. However, in this study, we found lower HIF-1a levels in maternal blood samples of preeclampsia group and no difference in umbilical cord blood samples when compared to controls.…”

Expression Profile of C19MC microRNAs in Placental Tissue in Pregnancy-Related Complications

“…Levels of HIF-1a in the placentas of preeclamptic patients have been found to be higher than the levels in placentas of healthy pregnant women (Tal, 2012;Sezer et al, 2013).…”

Adenosine A2A receptor regulates expression of vascular endothelial growth factor in feto-placental endothelium from normal and late-onset pre-eclamptic pregnancies

“…Nevertheless, placenta hypoxia can be present in LOPE as suggested for increased placental expression of hypoxia inducible factor [31]. Then, even increased angiogenesis observed in LOPE may be insufficient to overcome both the reduced oxygen delivery that is due to the infarcted placenta and the reduced oxygen delivery that would be predicted with failed remodeling of the maternal spiral arteries supplying the intervillous space [32].…”