No abstract

The objective of the study was to identify the profile of circulating C19MC microRNAs (miR-516-5p, miR-517∗, miR-518b, miR-520a∗, miR-520h, miR-525, and miR-526a) in patients with established preeclampsia (n = 63), fetal growth restriction (n = 27), and gestational hypertension (n = 23). We examined the correlation between plasmatic concentrations and expression levels of microRNAs and the severity of the disease with respect to clinical signs, requirements for the delivery, and Doppler ultrasound parameters. Using absolute and relative quantification approaches, increased extracellular C19MC microRNA levels (miR-516-5p, P = 0.037, P = 0.009; miR-517∗, P = 0.033, P = 0.043; miR-520a∗, P = 0.001, P = 0.009; miR-525, P = 0.026, P = 0.01; miR-526a, P = 0.03, P = 0.035) were detected in patients with preeclampsia. The association analysis pointed to no relationship between C19MC microRNA plasmatic concentrations and expression profile and identified risk factors for a poorer perinatal outcome. However, the dependence between the levels of plasmatic C19MC microRNAs and the pulsatility index in the middle cerebral artery and the values of cerebroplacental ratio was demonstrated. The study brought the interesting finding that the upregulation of miR-516-5p, miR-517∗, miR-520a∗, miR-525, and miR-526a is a characteristic phenomenon of established preeclampsia.

A planned caesarean section at 38 weeks of gestation was performed. A 3110g male was delivered with Apgar scores of 8 and 9 at 1 and 5 min. In third case, vasa previa was Type I, was diagnosed late, during elective caesarean section in 39 weeks of breach lie, with no risk factors for vasa previa. A 2990g female was delivered with Apgar scores of 8 and 9 at 1 and 5 min. In our opinion vaginal 2D and Doppler ultrasound in third trimester of fetal surveillance is of crucial importance in order to rule out the possibility of vasa previa, if risk factors are present. P15.23 Acral necrosis and upper brachial plexus palsy after prenatal fetal thrombosis