VEGF, apelin and HO-1 in diabetic patients with retinopathy: a correlation analysis

Abstract

Background: It's necessary to analyze the role of VEGF, apelin, and HO-1 in patients with type 2 diabetes (T2DM), and to evaluate its relevance to diabetic retinopathy (DR). Methods: T2DM patients who were treated in our hospital from December 1, 2018 to November 30, 2019 were included. T2DM patients were divided into non-DR (NDR) group, non-proliferative DR (NPDR) group, and proliferative DR (PDR) group. and healthy participants were selected as the control group. The value of VEGF, apelin, and HO1 in predicting PDR were analyzed by receiver operating characteristic (ROC) curve, and the relations of VEGF, apelin, HO-1 and clinical factors in PDR patients were analyzed by Pearson correlation analysis. Results: A total of 295 participants were included. The level of FPG and HbAlc in PDR group were significantly higher than that of other groups (all p < 0.05); the level of VEGF and apelin in PDR group were significantly higher than that of other groups (all p < 0.05), but the level of HO-1 in PDR group were significantly less than that of other groups(p = 0.017); the AUC of VEGF, apelin, HO-1 and combined use was 0.806(95%CI: 0.779-0.861), 0.819(95%CI: 0.765-0.878), 0.808(95%CI: 0.733-0.869) and 0.902(95%CI: 0.822-0.958) respectively, the AUC, sensitivity, specificity of the three combined use was significantly higher than that of single VEGF, apelin, HO-1 use(all p < 0.05). The cutoff values of serum VEGF, apelin, and HO-1 levels for predicting PDR were 163.85 pg/ml, 8.27 ng/ml, and 26.06 mmol/L respectively. Serum VEGF, apelin, and HO-1 in patients with PDR was related to the time course of DM, FPG and HbAlc (all p < 0.05). Conclusions: VEGF, apelin and HO-1 are related to the progress of DR, and the combined use of VEGF, apelin and HO-1 is beneficial to the diagnosis and treatment of PDR.

Effects of Glimepiride Combined with Recombinant Human Insulin Injection on Serum IGF-1, VEGF and TRACP-5b Oxidative Stress Levels in Patients with Type 2 Diabetes Mellitus

“…In this study, VEGF decreased, indicating that the combined use of glimepiride and recombinant human insulin injection can reduce blood sugar and inhibit the inhibition of VEGF in the liver. ere is an abnormally high expression of a variety of factors within the tumor, which thereby reduces the occurrence of tumor cells [21]. e effective rate of treatment in the study group was significantly higher than that in the control group (P < 0.05).…”

Genetic polymorphisms and protein levels in vocal fold leukoplakia: a systematic review

“…The LL genotype and the L allele of the (GT)n repeat polymorphisms in the HO-1 gene were risk factors for VFL development, and HO-1 concentrations were decreased in cases compared to controls ( 16 ), which indicates a lower production of anti-inflammatory and anti-oxidative substances, increasing the likelihood of developing diseases. The (GT)n repeat polymorphisms in HO-1 have been associated with severe acute pancreatitis ( 49 ), encephalitis in HIV infection ( 50 ), pediatric non-alcoholic fatty liver disease ( 51 ), and cancer ( 52 ), and lower levels of HO-1 are linked to diabetic retinopathy ( 53 ) and peripheral artery diseases ( 54 ).…”

The Role of Apelin–APJ System in Diabetes and Obesity

“…In addition, apelin is confirmed as a potent angiogenic factor, especially in retinal endothelium. It is reported that the serum apelin-13 level has a positive correlation with proliferative diabetic retinopathy, which is unrelated with VEGF (93) (94,95). Li Yang et al found that apelin can induce the proliferation, migration, and expression of the cytoskeleton and tight junction protein through the PI3K/Akt and MAPK/ERK pathways in human retinal pigment epithelial cells (96).…”