Vegetant Bromoderma in an Infant

Bel, Susana; Bartralot, R.; Garcia, Doroti de Oliveira; Aparicio, Gloria; Castells, A

doi:10.1046/j.1525-1470.2001.01954.x

Cited by 22 publications

(23 citation statements)

References 3 publications

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“…The histopathological features of bromoderma are downward proliferating epidermis, and intraepidermal abscesses filled with neutrophils, eosinophils and some desquamated keratinocytes, which are also observed in pyoderma gangrenosum. However, it is described that dense neutrophilic infiltrates are often observed in and around follicles in bromoderma . In retrospect, this characteristic feature had been observed in the first skin biopsy of this case (Fig.…”

Section: Discussionsupporting

confidence: 65%

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Bromoderma mimicking pyoderma gangrenosum caused by commercial sedatives

Oda

Tohyama

Murakami

et al. 2015

The Journal of Dermatology

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Bromoderma is a rare skin disorder caused by bromide intake. It presents as single or multiple papillomatous nodules or plaques, and ulcers studded with small pustules on the face or limbs. The clinical features of bromoderma are similar to those of pyoderma gangrenosum. A 41-year-old Japanese woman was diagnosed with pyoderma gangrenosum 11 years prior to presentation. Pyoderma had repeatedly appeared over her entire body despite treatment. She also frequently complained of syncopal episodes. She was admitted to our hospital after loss of consciousness and an episode of generalized convulsion. Laboratory tests revealed a negative serum anion gap and hyperchloremia. Her serum bromide level was significantly elevated, suggesting bromide intoxication. The patient had a 10-year history of high serum bromide levels. After the intake of bromide-containing sedatives was stopped, there was no recurrence of pyoderma in the absence of treatment. In conclusion, this case was diagnosed as bromoderma with commercial sedative-induced bromide intoxication. Although the US Food and Drug Administration have banned the use of bromides, over-the-counter (OTC) treatments containing bromides are still used in Japan and other countries. Long-term use of OTC medicines containing bromvalerylurea may result in the development of bromoderma. If unclarified neurological or psychiatric symptoms are associated with pyoderma, we propose measurement of the patient's serum chloride concentration. Determination of hyperchloremia is helpful for the diagnosis of chronic intoxication with bromides.

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Section: Discussionsupporting

confidence: 65%

“…Bromoderma occurs frequently on the face and limbs, which are rich with hair follicles and sebaceous glands, but it is not observed on the palmoplantar regions. Therefore, it is possible that bromide ions are eliminated through hair follicles and sebaceous glands and that they cause neutrophil accumulation . In addition, Hubner et al .…”

Section: Discussionmentioning

confidence: 99%

Bromoderma mimicking pyoderma gangrenosum caused by commercial sedatives

Oda

Tohyama

Murakami

et al. 2015

The Journal of Dermatology

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“…These include pustular and acneiform eruptions, panniculitis, vegetating nodules, and ulcers, which are usually referred to as vegetating bromoderma or bromoderma tuberosum. 4 Vegetating bromoderma may present with a single lesion as in the reported case. Our patient had just one vegetating and erosive plaque on her right leg and had no other skin eruption.…”

Section: Discussionmentioning

confidence: 57%

Single-plaque vegetating bromoderma

Maffeis

Musolino

Cambiaghi

2008

Journal of the American Academy of Dermatology

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“…Patients may present with more than one morphology. The pathogenesis of halogenoderma is not fully understood, but it is postulated that it may be a type of delayed hypersensitivity reaction …”

Section: Discussionmentioning

confidence: 99%