Single-plaque vegetating bromoderma

Maffeis, Laura; Musolino, Maria Carmela; Cambiaghi, Stefano

doi:10.1016/j.jaad.2007.08.011

Cited by 23 publications

(34 citation statements)

References 7 publications

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“…[98][99][100][101] However, some drugs containing bromide are still available and used for their sedative, antiepileptic, spasmolytic, and expectorant properties. [101] Moreover, some preparations are also available as non-prescription compounds on the French market. [100] The clinical cutaneous presentation is rather similar to iododerma.…”

Section: Brominementioning

confidence: 99%

Drug-Induced Acneiform Eruption

Du‐Thanh

Kluger

Bensalleh

et al. 2011

American Journal of Clinical Dermatology

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Drug-induced acne is a specific subset of acne that usually has some specific features, namely a monomorphic pattern, an unusual location of the lesions beyond the seborrheic areas, an unusual age of onset, a resistance to conventional acne therapy and, of course, the notion of a recent drug introduction. Many drugs can be responsible for such a clinical pattern. Corticosteroids, neuropsychotherapeutic drugs, antituberculosis drugs, and immunomodulating molecules are the more classical drugs associated with induced acne. Recently, new drugs, mainly targeted therapy in the field of oncology, such as epidermal growth factor receptor inhibitors, have been associated with an increased frequency of this adverse effect. Disruption of the culprit drug is rarely mandatory in cases of drug-induced acne. Close cooperation between the dermatologist and medical staff in charge of the patient is an important challenge to achieve optimal management of the initial disease.

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Section: Brominementioning

confidence: 99%

Drug-Induced Acneiform Eruption

Du‐Thanh

Kluger

Bensalleh

et al. 2011

American Journal of Clinical Dermatology

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“…As bromides accumulate in the body, side effects usually occur weeks to months after initiation of the drug or a dose increase [6,7]. In our case, the skin changes appeared within two weeks after starting the medication, which is unusually early.…”

Section: Discussionmentioning

confidence: 59%

“…In some cases, medications enhancing renal drug clearance, for example, furosemide or mannitol, have been used with some success [7]. Alternative drugs include all substances effective against generalized tonic-clonic seizures such as valproate, topiramate, phenobarbitone, and benzodiazepines.…”

Section: Discussionmentioning

confidence: 99%

Vegetating plaques in a patient with a seizure disorder

Schwieger‐Briel

Bast

Technau‐Hafsi

et al. 2015

J Deutsche Derma Gesell

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“…Moreover, in recent years, potassium bromides have again been used in severe uncontrollable childhood epilepsy in conjunction with other antiepileptic medicines . Therefore, the number of infantile bromoderma cases has increased again …”

Section: Discussionmentioning

confidence: 99%

Bromoderma mimicking pyoderma gangrenosum caused by commercial sedatives

Oda

Tohyama

Murakami

et al. 2015

The Journal of Dermatology

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Bromoderma is a rare skin disorder caused by bromide intake. It presents as single or multiple papillomatous nodules or plaques, and ulcers studded with small pustules on the face or limbs. The clinical features of bromoderma are similar to those of pyoderma gangrenosum. A 41-year-old Japanese woman was diagnosed with pyoderma gangrenosum 11 years prior to presentation. Pyoderma had repeatedly appeared over her entire body despite treatment. She also frequently complained of syncopal episodes. She was admitted to our hospital after loss of consciousness and an episode of generalized convulsion. Laboratory tests revealed a negative serum anion gap and hyperchloremia. Her serum bromide level was significantly elevated, suggesting bromide intoxication. The patient had a 10-year history of high serum bromide levels. After the intake of bromide-containing sedatives was stopped, there was no recurrence of pyoderma in the absence of treatment. In conclusion, this case was diagnosed as bromoderma with commercial sedative-induced bromide intoxication. Although the US Food and Drug Administration have banned the use of bromides, over-the-counter (OTC) treatments containing bromides are still used in Japan and other countries. Long-term use of OTC medicines containing bromvalerylurea may result in the development of bromoderma. If unclarified neurological or psychiatric symptoms are associated with pyoderma, we propose measurement of the patient's serum chloride concentration. Determination of hyperchloremia is helpful for the diagnosis of chronic intoxication with bromides.

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Single-plaque vegetating bromoderma

Cited by 23 publications

References 7 publications

Drug-Induced Acneiform Eruption

Drug-Induced Acneiform Eruption

Vegetating plaques in a patient with a seizure disorder

Bromoderma mimicking pyoderma gangrenosum caused by commercial sedatives

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