Vasodilator effects of quercetin in isolated rat vascular smooth muscle

Duarte, Juan; Pérez‐Vizcaíno, Francisco; Zarzuelo, Antonio; Jiménez, J.; Tamargo, Juan

doi:10.1016/0014-2999(93)90968-n

Cited by 196 publications

(119 citation statements)

References 24 publications

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“…Formica and Regelson (1995) reported that quercetin exhibited antioxidant and spasmolytic effects. It induced relaxation of cardiovascular smooth muscle (Duarte et al, 1993;Formica and Regelson, 1995) which could lead to lower blood pressure in vivo. This justifies its use in the treatment of hypertension in the central plateau of Burkina Faso.…”

Section: Discussionmentioning

confidence: 99%

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Effects of two medicinal plants Psidium guajava L. (Myrtaceae) and Diospyros mespiliformis L. (Ebenaceae) leaf extracts on rat skeletal muscle cells in primary culture

Belemtougri

Constantin

Cognard

et al. 2006

J. Zhejiang Univ. - Sci. B

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Crude decoction, aqueous and ethanolic extracts of two medicinal plants (Psidium guajava and Diospyros mespiliformis), widely used in the central plateau of Burkina Faso to treat many diseases were evaluated for their antagonistic effects on caffeine induced calcium release from sarcoplasmic reticulum of rat skeletal muscle cells. These different extracts showed a decrease of caffeine induced calcium release in a dose dependent manner. Comparison of the results showed that Psidium guajava leaf extracts are more active than extracts of Diospyros mespiliformis and that crude decoctions show better inhibitory activity. The observed results could explaine their use as antihypertensive and antidiarrhoeal agents in traditional medicine, by inhibiting intracellular calcium release.

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Section: Discussionmentioning

confidence: 99%

“…This justifies its use in the treatment of hypertension in the central plateau of Burkina Faso. It has been shown that quercetin has relaxant effects on vascular and intestinal smooth muscle (Duarte et al, 1993;Morales et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

Effects of two medicinal plants Psidium guajava L. (Myrtaceae) and Diospyros mespiliformis L. (Ebenaceae) leaf extracts on rat skeletal muscle cells in primary culture

Belemtougri

Constantin

Cognard

et al. 2006

J. Zhejiang Univ. - Sci. B

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“…12 In addition, rutin improves the resistance and permeability of capillary vessels. 13,14 The use of rutin is relatively limited due to its low water solubility (0.125 g/L), 15 which is what led to our research group's desire to increase the solubility of a rutin derivative (as synthesized by introducing carboxylate groups on rutin's sugar moiety, by means of a modification of the method developed by Alluis et al). 16 Moreover, we took into consideration the influence of the chemical modification via evaluation in vitro of two model procedures: antiradical capacity by luminol/AAPH system and antioxidant activity by lipid peroxidation in brain homogenate.…”

Section: Introductionmentioning

confidence: 99%

The synthesis of a water-soluble derivative of rutin as an antiradical agent

Pedriali¹,

Fernandes²,

Bernusso³

et al. 2008

Quím. Nova

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Recebido em 13/6/07; aceito em 20/6/08; publicado na web em 31/10/08The purpose of this study was to synthesize a water-soluble derivative of rutin (compound 2) by introducing carboxylate groups on rutin's sugar moiety. The rutin derivative showed an almost 100-fold solubility increase in water. The antiradical capacity of compound 2 was evaluated using the luminol/AAPH system, and the derivative's activity was 1.5 times greater than that of Trolox ® . Despite the derivative's high solubility in water (log P = -1.13), lipid peroxidation of brain homogenate membranes was very efficiently inhibited (inhibition values were only 19% lower than the inhibition values of rutin).

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“…On the cardiovascular system flavonoids produced positive chronotropic and antiarrhythmic effects (Occhiuto et al, 1991;Laekeman et al, 1986) and most of them exhibited vasodilatory actions (Beretz et al, 1980;Ubeda et al, 1991;Ko et al, 1991;Duarte et al, 1993). Although this vascular smooth muscle relaxation has been attributed to several mechanisms including decreased transmembrane 45Ca2+ uptake (Ko et al, 1991;Duarte et al, 1993) and an inhibitory effect on cAMP-and cGMPphosphodiesterase [PDE, Beretz et al (1980Beretz et al ( , 1981] or protein kinase C (PKC) activity (Duarte et al, 1993), the mechanism of action is far from clear. The present study was undertaken to evaluate the vasodilatory effects of seven flavonoids ( Fig.…”

Section: Introductionmentioning

confidence: 99%

Vasodilatory effects of flavonoids in rat aortic smooth muscle. Structure-activity relationships

Duarte

Vizcaíno²,

Utrilla

et al. 1993

General Pharmacology: The Vascular System

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285

192

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Abstract--1. Flavonoids relaxed the contractions induced by noradrenaline, KCI or phorbol 12-myristate,13-acetate in rat aortic strips, the order of potency being: flavonols (quercetin, kaempferol, pentamethylquereetin)>flavones(luteolin, apigenin)>flavanols((+)-catechin, (-)-epicatechin) which correlates with the reported order of potency to inhibit protein kinase C.2. The relaxant effects of kaempferol and luteolin were slightly potentiated by isoprenaline and those of pentamethylquercetin, kaempferol and apigenin by sodium nitroprusside.3. It is concluded that the main vasodilatory mechanism of flavonoids seems to be the inhibition of protein kinase C. Inhibition of cyclic nucleotide phosphodiesterases or decreased Ca 2+ uptake may also contribute to their vasodilatory effects.

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Vasodilator effects of quercetin in isolated rat vascular smooth muscle

Cited by 196 publications

References 24 publications

Effects of two medicinal plants Psidium guajava L. (Myrtaceae) and Diospyros mespiliformis L. (Ebenaceae) leaf extracts on rat skeletal muscle cells in primary culture

Effects of two medicinal plants Psidium guajava L. (Myrtaceae) and Diospyros mespiliformis L. (Ebenaceae) leaf extracts on rat skeletal muscle cells in primary culture

The synthesis of a water-soluble derivative of rutin as an antiradical agent

Vasodilatory effects of flavonoids in rat aortic smooth muscle. Structure-activity relationships

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