Vasoactive intestinal peptide alleviates food allergy via restoring regulatory B cell functions

Zeng, Hao-Tao; Zhao, Miao; Yang, Shaobo; Huang, Huang; Geng, Xinyu; Liu, Jiang‐Qi; Yang, Gui; Li, Dongcai; Yang, Litao; Zheng, Peng‐Yuan; Yang, Ping‐Chang

doi:10.1016/j.imbio.2019.08.006

Cited by 7 publications

(18 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, it is necessary to investigate the mechanism of IL-10 mRNA decay. In line with previous reports [ 17 , 18 ], the present data also show that IL-10 mRNA decayed in B cells soon after the removal of IL-10 inducers and confirm that TTP is the factor to induce IL-10 mRNA decay in B cells.…”

Section: Discussionsupporting

confidence: 93%

“…The results indicate that the presence of PA counteracts the spontaneous IL-10 mRNA decay in B cells. underlying mechanism remains to be further investigated [18]. In line with this, we also found that CD5 + B cells, but not CD5 -B cells, collected from AR patients showed higher TTP expression (Figures 4(a)-4(c)).…”

Section: Serum Pa Levels Are Positively Associated Withsupporting

confidence: 81%

“…Our previous studies showed that TTP bound IL-10 mRNA to induce IL-10 decay in B cells of an experimental food allergy study, but the underlying mechanism remains to be further investigated [ 18 ]. In line with this, we also found that CD5 + B cells, but not CD5 − B cells, collected from AR patients showed higher TTP expression (Figures 4(a) – 4(c) ).…”

Section: Resultsmentioning

confidence: 99%

“…Thus, to understand the mechanism by which IL-10 decreased in B cells is of importance. We [ 17 , 18 ] and others [ 23 ] previously found that the IL-10 mRNA relatively easily decayed, which degraded spontaneously soon after splicing before completing the IL-10 protein synthesis. Thus, it is necessary to investigate the mechanism of IL-10 mRNA decay.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Short-Chain Fatty Acids Promote Immunotherapy by Modulating Immune Regulatory Property in B Cells

Zhou

Xie

Han

et al. 2021

Journal of Immunology Research

Self Cite

View full text Add to dashboard Cite

The dysfunction of regulatory B cells (Breg) may result in immune inflammation such as allergic rhinitis (AR); the underlying mechanism is not fully understood yet. Short-chain fatty acids, such as propionic acid (PA), have immune regulatory functions. This study is aimed at testing a hypothesis that modulates PA production alleviating airway allergy through maintaining Breg functions. B cells were isolated from the blood obtained from AR patients and healthy control (HC) subjects. The stabilization of IL-10 mRNA in B cells was tested with RT-qPCR. An AR mouse model was developed to test the role of PA in stabilizing the IL-10 expression in B cells. We found that the serum PA levels were negatively correlated with the serum Th2 cytokine levels in AR patients. Serum PA levels were positively associated with peripheral CD5+ B cell frequency in AR patients; the CD5+ B cells were also IL-10+. The spontaneous IL-10 mRNA decay was observed in B cells, which was prevented by the presence of PA through activating GPR43. PA counteracted the effects of Tristetraprolin (TTP) on inducing IL-10 mRNA decay in B cells through the AKT/T-bet/granzyme B pathway. Administration of Yupinfeng San, a Chinese traditional medical formula, or indole-3-PA, induced PA production by intestinal bacteria to stabilize the IL-10 expression in B cells, which promoted the allergen specific immunotherapy, and efficiently alleviated experimental AR. In summary, the data show that CD5+ B cells produce IL-10. The serum lower PA levels are associated with the lower frequency of CD5+ B cells in AR patients. Administration with Yupinfeng San or indole-3-PA can improve Breg functions and alleviate experimental AR.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Serum Pa Levels Are Positively Associated Withsupporting

confidence: 81%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Short-Chain Fatty Acids Promote Immunotherapy by Modulating Immune Regulatory Property in B Cells

Zhou

Xie

Han

et al. 2021

Journal of Immunology Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…In addition, the dysfunction of regulatory B cells is correlated with food allergy, which can be regulated by vasoactive intestinal peptide and thrombospondin. [ 55,56 ] Whether regulatory B cells participate in LcZ requires further investigations.…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus Casei Zhang Alleviates Shrimp Tropomyosin‐Induced Food Allergy by Switching Antibody Isotypes through the NF‐κB‐Dependent Immune Tolerance

Xie

Wang

et al. 2020

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Scope: Shellfish allergy is an important cause of food allergy, and tropomyosin (TM) is the major allergen within shellfish. Probiotics are safe bacteria that benefit host health and nutrition and is proposed as a novel approach for treating immunological diseases, including food allergies. Methods and results: The probiotic strain Lactobacillus casei Zhang (LcZ) isolated from koumiss is investigated for its capacity to modulate food allergyinduced by TM in BALB/c mice. Oral administration of LcZ attenuated allergy symptoms and intestinal epithelial damage. Furthermore, flow cytometry, real-time quantitative PCR, and ELISA demonstrated that LcZ administration altered the development and function of dendritic cells (DCs), T cells, and B cells, finally resulting in the change of TM-specific antibody isotypes into a tolerogenic pattern. Moreover, an in vitro spleen cell culture model reveals that LcZ directly modulates regulatory tolerogenic DC and T cell development, dependent on the activation of the nuclear factor kappa B (NF-B) signaling pathway. Conclusion: This work indicates the ability of LcZ to alleviate TM-induced food allergy and demonstrates the involvement of the tolerogenic immune cells and NF-B signaling pathway, indicating LcZ to be a potential immunomodulator and immunotherapy assistor.

show abstract

Roles of gastrointestinal polypeptides in intestinal barrier regulation

Xie

Geng

et al. 2022

Peptides

View full text Add to dashboard Cite

Vasoactive intestinal peptide alleviates food allergy via restoring regulatory B cell functions

Cited by 7 publications

References 32 publications

Short-Chain Fatty Acids Promote Immunotherapy by Modulating Immune Regulatory Property in B Cells

Short-Chain Fatty Acids Promote Immunotherapy by Modulating Immune Regulatory Property in B Cells

Lactobacillus Casei Zhang Alleviates Shrimp Tropomyosin‐Induced Food Allergy by Switching Antibody Isotypes through the NF‐κB‐Dependent Immune Tolerance

Roles of gastrointestinal polypeptides in intestinal barrier regulation

Contact Info

Product

Resources

About