Roles of gastrointestinal polypeptides in intestinal barrier regulation

Xie, Xiaoxi; Geng, Chong; Li, Xiao; Liao, Juan; Li, Yanni; Guo, Yaoyu; Wang, Chunhui

doi:10.1016/j.peptides.2022.170753

Cited by 13 publications

(3 citation statements)

References 173 publications

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“…Short-chain fatty acids (SCFAs) regulate various activities in the GI tract, including cell proliferation and differentiation, water and electrolyte absorption, hormone secretion, and immune system activation [ 22 ]. We found that EA significantly increased acetic acid, propionic acid, isobutyric acid, butyric acid, isovaleric acid, valeric acid, and caproic acid in the feces of FD rats.…”

Section: Resultsmentioning

confidence: 99%

Electroacupuncture improves low-grade duodenal inflammation in FD rats by reshaping intestinal flora through the NF-κB p65/NLRP3 pyroptosis pathway

Han,

Kang,

Jin

et al. 2024

Heliyon

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Section: Resultsmentioning

confidence: 99%

Electroacupuncture improves low-grade duodenal inflammation in FD rats by reshaping intestinal flora through the NF-κB p65/NLRP3 pyroptosis pathway

Han,

Kang,

Jin

et al. 2024

Heliyon

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“…The microbiota changes intestinal bacterial biofilms and disrupts TME homeostasis and the immune response. It may cause immunosuppression and influence the metabolism of drugs [ 205 , 206 ]. Intratumoral microorganisms are more common in mucosal cancers, including CRC [ 207 ].…”

Section: Antitumor Effects Of Somatostatin In Crcmentioning

confidence: 99%

“…The microbiota changes intestinal bacterial biofilms and disrupts TME homeostasis and the immune response. It may cause immunosuppression and influence the metabolism of drugs [205,206].…”

Section: Somatostatin and Colorectal Cancer's Colon Microbiome (Micro...mentioning

confidence: 99%

The State-of-the-Art Mechanisms and Antitumor Effects of Somatostatin in Colorectal Cancer: A Review

Kasprzak,

Geltz

2024

Biomedicines

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Somatostatin, a somatotropin release inhibiting factor (SST, SRIF), is a widely distributed multifunctional cyclic peptide and acts through a transmembrane G protein-coupled receptor (SST1-SST5). Over the past decades, research has begun to reveal the molecular mechanisms underlying the anticancer activity of this hormonal peptide. Among gastrointestinal tract (GIT) tumors, direct and indirect antitumor effects of SST have been documented best in gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and less well in non-endocrine cancers, including sporadic colorectal cancer (CRC). In the latter, the signaling pathways involved in the antitumor function of SST are primarily MAPK/ERK/AKT and Wnt/β–catenin. Direct (involving the MAPK pathway) and indirect (VEGF production) antiangiogenic effects of SST in CRC have also been described. The anti-inflammatory role of SST in CRC is emphasized, but detailed molecular mechanisms are still being explored. The role of SST in tumor genome/tumor microenvironment (TME)/host’s gut microbiome interactions is only partially known. The results of SST analogues (SSAs)’ treatment of sporadic CRC in monotherapy in vivo are not spectacular. The current review aims to present the state-of-the-art mechanisms and antitumor activity of endogenous SST and its synthetic analogues in CRC, with particular emphasis on sporadic CRC.

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