Vasculogenic mimicry

Folberg, Robert; Maniotis, Andrew J.

doi:10.1111/j.1600-0463.2004.apm11207-0810.x

Cited by 260 publications

(209 citation statements)

References 78 publications

(183 reference statements)

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“…BMP4 in angiogenesis in melanoma T Rothhammer et al distribute plasma and red blood cells in vivo and in vitro, enabling the tumor to become, at least in part, independent of angiogenesis (Folberg et al, 2000;Hendrix et al, 2003;Folberg and Maniotis, 2004). Vasculogenic mimicry, however, is controversially discussed.…”

Section: Bmp4 In Angiogenesis In Melanoma T Rothhammer Et Almentioning

confidence: 99%

“…On the other hand, melanoma cells are able to de novo generate microcirculatory channels that are composed of extracellular matrix and lined by tumor cells. This process of formation of non-endothelial cell-lined channels has been called 'vasculogenic mimicry' (Maniotis et al, 1999;Folberg et al, 2000;Folberg and Maniotis, 2004). Several genes like VE-cadherin (vascular endothelial cadherin), laminin 5 g2 chain, TIE-1 (tyrosine kinase with immunoglobulin and EGF factor homology domains) and EphA2 (epithelial cell receptor protein-tyrosine kinase), known to be important in angiogenesis, were also identified to play a role in vasculogenic mimicry (Hendrix et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Functional implication of BMP4 expression on angiogenesis in malignant melanoma

et al. 2006

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Analyses of malignant melanomas revealed a strong expression of bone morphogenic proteins (BMPs) and their autocrine effect in promoting cell invasion and migration. Here, we report a paracrine effect of BMPs on the vascular network. Both BMP2 and BMP4 induced tube formation as well as the migratory efficiency of microvascular endothelial cells. Melanoma cells with reduced BMP activity attracted less endothelial cells in invasion assays than control cells. Furthermore, reduction of BMPs in melanoma cells had a strong effect on vasculogenic mimicry. Tube formation on matrigel was analysed for melanoma cells as well as in co-cultures of endothelial and melanoma cells. Melanoma cells with reduced BMP activity were not capable of forming cordlike structures by themselves and additionally inhibited tube formation of the endothelial cells. Genes involved in angiogenesis turned out to be strongly downregulated in these cell clones. Tumors derived from cells with impaired BMP activity showed reduced tumor growth or large necrotic areas owing to lack of angiogenesis in in vivo analyses.

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Section: Bmp4 In Angiogenesis In Melanoma T Rothhammer Et Almentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Functional implication of BMP4 expression on angiogenesis in malignant melanoma

et al. 2006

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“…These channels constitute the vasculogenic mimicry (VM) and the process is called "vasculogenesis." 3,4 Since its discovery, VM has been described in many kinds of tumors, such as melanoma, 5 synovial sarcoma, 6 rhabdomyosarcoma, 6 osteosarcoma, 7 inflammatory and ductal breast carcinoma 8 and ovarian carcinoma. 9,10 Most of these studies have shown some association between angiogenesis or VM proliferation in relationship with the aggressiveness of the tumor.…”

Section: Introductionmentioning

confidence: 99%

Vasculogenic mimicry is a marker of poor prognosis in prostate cancer

Liu

Yang

Meng

et al. 2012

Cancer Biology & Therapy

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“…In vasculogenic mimicry of the patterned matrix type, 3 highly invasive tumor cells form looping patterns rich in extracellular matrix (ECM) in three-dimensional (3D) culture conditions. 1 Highly invasive tumor cells do not generate these patterns when grown under monolayer conditions or on thin matrix, and poorly invasive tumor cells do not generate these patterns under any culture condition.…”

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confidence: 99%

Tumor Cell Plasticity in Uveal Melanoma

Folberg

Arbieva

Moses

et al. 2006

The American Journal of Pathology

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The histological detection of laminin-rich vasculogenic mimicry patterns in human primary uveal melanomas is associated with death from metastases. We therefore hypothesized that highly invasive uveal melanoma cells forming vasculogenic mimicry patterns after exposure to a laminin-rich three-dimensional microenvironment would differentially express genes associated with invasive and metastatic behavior. However, we discovered that genes associated with differentiation (GDF15 and ATF3) and suppression of proliferation (CDKNa1/p21) were up-regulated in highly invasive uveal melanoma cells forming vasculogenic mimicry patterns, and genes associated with promotion of invasive and metastatic behavior such as CD44, CCNE2 (cyclin E2), THBS1 (thrombospondin 1), and CSPG2 (chondroitin sulfate proteoglycan; versican) were down-regulated. After forming vasculogenic mimicry patterns, uveal melanoma cells invaded only short distances, failed to replicate, and changed morphologically from the invasive epithelioid to the indolent spindle A phenotype. In human tissue samples, uveal melanoma cells within vasculogenic mimicry patterns assumed the spindle A morphology, and the expression of Ki67 was significantly reduced in adjacent melanoma cells. Thus, the generation of vasculogenic mimicry patterns is accompanied by dampening of the invasive and metastatic uveal melanoma genotype and phenotype and underscores the plasticity of these cells in response to cues from the microenvironment. The term vasculogenic mimicry describes the formation of perfusion pathways in tumors by highly invasive, genetically deregulated tumor cells 1,2 : vasculogenic because, although these pathways do not form from preexisting vessels, they distribute plasma and may contain red blood cells and mimicry because the pathways are not blood vessels and merely mimic vascular function. In vasculogenic mimicry of the patterned matrix type, 3 highly invasive tumor cells form looping patterns rich in extracellular matrix (ECM) in three-dimensional (3D) culture conditions. 1 Highly invasive tumor cells do not generate these patterns when grown under monolayer conditions or on thin matrix, and poorly invasive tumor cells do not generate these patterns under any culture condition. 1,4 These looping patterns, termed the "fluid-conducting meshwork," 5 connect to endothelial cell-lined blood vessels 4,6 and conduct fluid in vitro 1,4 and in animal models of melanoma. 5,7,8 Vasculogenic mimicry patterns are composed of laminin, 5,9,10 collagen types IV 11 and VI, 12 fibronectin, 13 Pathology, Vol. 169, No. 4, October 2006 Copyright © American Society for Investigative Pathology DOI: 10.2353/ajpath.2006 1376 focally and weakly for collagen I and are structurally different from stromal host-derived fibrovascular septa. There is a strong association between the histological detection of vasculogenic mimicry patterns in primary uveal [15][16][17][18][19][20][21] and cutaneous 22,23 melanomas and subsequent death from metastasis, consistent with the in vitro observatio...

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Vasculogenic mimicry

Cited by 260 publications

References 78 publications

Functional implication of BMP4 expression on angiogenesis in malignant melanoma

Functional implication of BMP4 expression on angiogenesis in malignant melanoma

Vasculogenic mimicry is a marker of poor prognosis in prostate cancer

Tumor Cell Plasticity in Uveal Melanoma

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