Vasculitis and cancer

Henoch-Schönlein purpura associated with malignancy in adults

“…The incidence of vasculitis in patients with malignancy is estimated to be 2.5% to 5%. 2,6,[8][9][10][11][12] Although myeloproliferative and lymphoproliferative malignancies were 3 to 5 times more common than solid tumors in all types of vasculitis, solid tumors were more common in association with HSP. [11][12][13][14] To date, there have been only 31 reported patients with HSP and coexisting malignancy in the world literature (Table I).…”

Leukocytoclastic Vasculitis as Early Manifestation of Epstein-Barr Virus–Positive Diffuse Large B-Cell Lymphoma of the Elderly

“…In approximately 5% of the cases, it presents as a paraneoplastic syndrome associated with hematologic or lymphoid neoplasms. 1,10,11 Vasculitides associated with lymphoid neoplasms could be divided into cutaneous and systemic forms, the former being more common. Usually, it follows a benign course, although a few cases with more aggressive clinical course had been reported.…”

“…Depending on the size and their location, there could be different patterns of inflammatory process, leading to necrosis or scarring. 1 The possibility that a neoplasm can exert a vasculitic reaction was initially proposed in 1986 by Longley, et al 2 In the same year, 2 diagnostic criteria were established to define a vasculitis as a paraneoplastic phenomenon. First, a simultaneous occurrence of vasculitis and neoplasia, and second both conditions have to be present with a parallel clinical course.…”

“…Of these, 88 were associated to leukocytoclastic vasculitis (LCV), and the majority of these cases were associated with hematologic or lymphoid malignancies (66% of cases). 1,4 Classical Hodgkin lymphoma, adult T-cell leukemia/ lymphoma, mycosis fungoides, and diffuse large B-cell lymphoma (DLBCL) are among the most common lymphoid neoplasm associated with LCV. 5,6 DLBCL is a heterogeneous entity that comprises approximately 30% of cases of nonHodgkin lymphoma (NHL).…”

Testicular Pain Followed by Microscopic Hematuria, a Renal Mass, Palpable Purpura, Polyarthritis, and Hematochezia

“…It has been estimated that less than 5% of all vasculitides are related to paraneoplastic mechanisms, yet most data are taken from case series and case reports. 9 These cases of vasculitis were more frequently associated with hematologic malignancies than solid tumors. A review of 200 cases of vasculitis found that hairy cell leukemia was the most frequently observed hematologic malignancy occurring with vasculitis and that leukocytoclastic vasculitis was the most common paraneoplastic vasculitis.…”