Testicular Pain Followed by Microscopic Hematuria, a Renal Mass, Palpable Purpura, Polyarthritis, and Hematochezia

Maynard, Janet W.; Christopher‐Stine, Lisa; Gelber, Allan C.

doi:10.1097/rhu.0b013e3181fe8bbe

Cited by 6 publications

(5 citation statements)

References 14 publications

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“…HSP is a small-vessel vasculitis generally found in children [4]. Typical manifestations include palpable purpura, arthritis, abdominal pain, and renal complications [3].…”

Section: Resultsmentioning

confidence: 99%

“…Clinical manifestations of HSP include palpable purpura, arthritis, abdominal pain, and renal complications [3]. HSP is diagnosed by its clinical manifestations and the presence of IgA deposits in walls of arterioles, capillaries, and venules of afflicted organs [4,5]. Diagnosis of HSP is not clear in many cases due to differential diagnosis and diversity of symptom presentation.…”

Section: Introductionmentioning

confidence: 99%

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Urological Manifestations of Henoch-Schonlein Purpura: A Review

et al. 2015

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Henoch-Schonlein purpura (HSP) is an immune-mediated systemic vasculitis generally found in children. The standard manifestations of HSP are palpable purpura, arthritis, abdominal pain, and renal complications. Although less common, there are significant urological manifestations associated with HSP. The primary objective of this review is to encourage better understanding and management of HSP by emphasizing the common and rare manifestations of HSP, how they are diagnosed, and the latest treatment options for mild to severe complications. Medline searches of HSP and its urological manifestations were conducted along with searches on current diagnostic and treatment methods. Urological manifestations of HSP involve the kidney, ureter, bladder, prostate, scrotum, testicle, and penis. Diagnosis and management of HSP are not always clear due to differential diagnosis and diversity of symptom presentation. Treatment for HSP is mainly supportive and includes use of nonsteroidal anti-inflammatory drugs for pain relief. In more severe cases, glucocorticoids, methylprednisolone, plasmapheresis, and peritoneal and hemodialysis are reported successful. It is important to note different symptoms of HSP in order to distinguish HSP from other diseases. Early diagnosis may prevent severe complications. Treatment options vary from conservative to invasive depending on the severity of the disease and time frame of diagnosis.

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“…HSP is a small-vessel vasculitis generally found in children [4]. Typical manifestations include palpable purpura, arthritis, abdominal pain, and renal complications [3].…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Urological Manifestations of Henoch-Schonlein Purpura: A Review

et al. 2015

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“…Regarding scrotal involvement in adults with IgAV, the severity and adequate treatment are also not defined. In most of the reviewed case reports in adults [ 15 - 18 ], the use of corticosteroids was implemented. In the presented case, corticosteroids were also employed, with an early improvement of scrotal manifestations and sonographic changes, as well as resolution of other IgAV-related symptoms.…”

Section: Discussionmentioning

confidence: 99%

IgA Vasculitis with scrotal involvement - a rare presentation in adults

Viegas¹,

Lopes²,

Pereira³

2023

Arch Clin Cases

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"IgA vasculitis (IgAV) is a small-vessel vasculitis common in children but rare in adults. It is usually an auto-limited disease in children but has a more severe course and worse prognosis in adults. The classical manifestations are non-thrombocytopenic purpura, arthralgias, gastrointestinal involvement and renal involvement. Herein we report a case of a 39-year-old man with a rash of the lower limbs associated with testicular and lower abdominal pain. The initial study revealed increased inflammatory biomarkers and enlarged left testis with bilateral ischemic areas on doppler ultrasound. A cutaneous biopsy later revealed leukocytoclastic vasculitis, confirming the diagnosis of IgAV with scrotal involvement. The patient started prednisolone, with improvement in the first week and sustained remission after two years of follow-up. This case report describes an adult with IgAV and scrotal involvement, which is rarely reported in adults and appears to be different from the one in children. The prevalence of scrotal involvement is presumably underestimated. In all men with IgAV, a scrotal examination should be performed and ultrasonography accordingly since it affects the treatment and follow-up. Recommendations for IgAV diagnosis and treatment in adults are still lacking and more research is needed. "

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“…Dermatological manifestations of RCC, although seldom observed, may be represented by nodules: (i) metastasis (presented in 3–6% of the RCC) mostly found in the scalp, the thorax, and the abdomen; 1 , 19 - 22 or (ii) leukocytoclastic vasculitis, with or without ulceration. 23 Even rarer, the skin manifestations may also be represented by paraneoplastic syndromes, such as AN, palmar fibromatosis, erythrodermia, and bullous pemphigoid. 24 , 25…”

Section: Discussionmentioning

confidence: 99%

Acanthosis Nigricans associated with clear-cell renal cell carcinoma

Campos

Narvaez

Reis

et al. 2016

ACR

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Acanthosis nigricans (AN), an entity recognized since the 19th century, is a dermatopathy associated with insulin-resistant conditions, endocrinopathies, drugs, chromosome abnormalities and neoplasia. The latter, also known as malignant AN, is mostly related to abdominal neoplasms. Malignant AN occurs frequently among elderly patients. In these cases, the onset is subtle, and spreading involves the flexural regions of the body, particularly the axillae, palms, soles, and mucosa. Gastric adenocarcinoma is the most frequent associated neoplasia, but many others have been reported. Renal cell carcinoma (RCC), although already reported, is rarely associated with malignant AN. The authors report the case of a woman who was being treated for depression but presented a long-standing and marked weight loss, followed by darkening of the neck and the axillary regions. Physical examination disclosed a tumoral mass in the left flank and symmetrical, pigmented, velvety, verrucous plaques on both axillae, which is classical for AN. The diagnostic work-up disclosed a huge renal mass, which was resected and further diagnosed as a RCC. The post-operative period was uneventful and the skin alteration was evanescent at the first follow-up consultation. The authors call attention to the association of AN with RCC.

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Testicular Pain Followed by Microscopic Hematuria, a Renal Mass, Palpable Purpura, Polyarthritis, and Hematochezia

Cited by 6 publications

References 14 publications

Urological Manifestations of Henoch-Schonlein Purpura: A Review

Urological Manifestations of Henoch-Schonlein Purpura: A Review

IgA Vasculitis with scrotal involvement - a rare presentation in adults

Acanthosis Nigricans associated with clear-cell renal cell carcinoma

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