Vascular Organization of the Hystricomorph Placenta: a Comparative Study in the Agouti, Capybara, Guinea Pig, Paca and Rock Cavy

Miglino, María Angélica; Carter, Anthony Michael; Ambrósio, Carlos Eduardo; Bonatelli, Marina; Oliveira, Moacir Franco de; Ferraz, Rosa Helena dos Santos; Rodrigues, Rosangela; Santos, Tatiana Carlesso dos

doi:10.1016/j.placenta.2003.11.002

Cited by 50 publications

(42 citation statements)

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“…This popularity has increased the interest in its behavior, physiology and management, leading it to be used as an experimental animal (Taylor & Lee 2012, Dumitrascu et al 2013). Due to anatomical and physiological similarities, related to pregnancy and placentation (Miglino et al 2004, Mess 2007, Vasconcelos et al 2013, this species became extremely important as an experimental model for human placentation, as well as for respiratory diseases (Canning & Chou 2008, Skerry et al 2013), cardiovascular problems (Zaragoza et al 2011), and bacterial, viral and fungal infections (Pica et al 2012, Zhang et al 2012.…”

Section: Introductionmentioning

confidence: 99%

Development of the central nervous system in guinea pig (Cavia porcellus, Rodentia, Caviidae)

et al. 2016

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This study describes the development of the central nervous system in guinea pigs from 12th day post conception (dpc) until birth. Totally, 41 embryos and fetuses were analyzed macroscopically and by means of light and electron microscopy. The neural tube closure was observed at day 14 and the development of the spinal cord and differentiation of the primitive central nervous system vesicles was on 20th dpc. Histologically, undifferentiated brain tissue was observed as a mass of mesenchymal tissue between 18th and 20th dpc, and at 25th dpc the tissue within the medullary canal had higher density. On day 30 the brain tissue was differentiated on day 30 and the spinal cord filling throughout the spinal canal, period from which it was possible to observe cerebral and cerebellar stratums. At day 45 intumescences were visualized and cerebral hemispheres were divided, with a clear division between white and gray matter in brain and cerebellum. Median sulcus of the dorsal spinal cord and the cauda equina were only evident on day 50. There were no significant structural differences in fetuses of 50 and 60 dpc, and animals at term were all lissencephalic. In conclusion, morphological studies of the nervous system in guinea pig can provide important information for clinical studies in humans, due to its high degree of neurological maturity in relation to its short gestation period, what can provide a good tool for neurological studies.

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Section: Introductionmentioning

confidence: 99%

Development of the central nervous system in guinea pig (Cavia porcellus, Rodentia, Caviidae)

et al. 2016

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“…Roedores são os mais amplamente usados como modelo experimental, seja para a produção de conhecimento intrín-seco aos mesmos, ou para sua utilização como instrumento de compreensão de mecanismos normais ou patológicos, especialmente aqueles vinculados a processos reprodutivos (Miglino et al 2004e Conceição et al 2008) e a função e disfunção do trato urinário inferior (McMurray et al 2006).…”

Section: Introductionunclassified

Descrição morfológica e morfométrica da glândula vesicular de cobaias durante o desenvolvimento pós-natal

Gradela

Nunes

Matos³

et al. 2013

Pesq. Vet. Bras.

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Pesq. Vet. Bras. 33(7): 942-948, julho 2013 942 RESUMO.-Glândulas vesiculares são essenciais para a reprodução, pois suas secreções afetam a função espermá-tica. Cobaias (Cavia porcellus) são um excelente modelo experimental para estudo destas glândulas, contudo não existem dados morfológicos e morfométricos durante seu desenvolvimento. Neste estudo a morfologia (projeções das pregas (PP) e altura das células epiteliais (AE) da tú-nica mucosa) e a morfometria (massa (MG), volume (VG), comprimento (CG), largura das porções cranial (LCR), mé-dia (LM) e caudal (LCA)) das glândulas vesiculares foram determinadas em cobaios (N= 25) com uma (S1), três (S3), (Cavia porcellus) are an excellent experimental model for studying vesicular glands, but no morphologic and morphometric data during its development are available. In the present study, the morphology (projections of the folds (PF) and epithelial tissue high (EH) of the mucosa) and the morphometry (mass (GM), volume (GV), length (GC), width of the portions cranial (CRW), medium (MW) and caudal (CAW)) of the vesicular glands were determined at 1, 3, 5, 8, and 11-weeks of age in male guinea pigs (n = 5/age group). In addition, body mass (BM), body length (BL) and height (BH) and organo-somatic index (OSI) were also determined and the simple correlation coefficient (r) was established between the variables. The glands were restricted to the pelvic cavity, and had its interior filled with a semi-solid mass and, after S8, they occupied also the abdominal cavity and the contents were increased significantly. The mucous membrane presented variable folding and simple columnar epithelium. BM, BL and BH increased continuously with age. GM, GV, GC and CAW did not change from 1 to 5-weeks of age, but increased at 8-weeks of age; GM, GV and LCA also increased at 11-weeks of age. OSI and PF increased at 8 and 11-weeks of age and EH at 5, 8 and 11-weeks of age. There was significant (r) between age, body and glandular parameters; OSI and GM at 8 and 11-weeks of age; age and PF, age and EH and between PF and EH. In conclusion, the guinea pigs vesicular glands followed morphology observed in rats and hamsters, but differed in some aspects from others histricomorfs, can be used as experimental model and its morphological and morphometric development can be divided into three phases: 1 to 5-weeks of age, when they are discrete; 6 to 8-weeks of age when they are generally sharp and >8-weeks of age, when there is an intense increase of the secretory capacity.

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“…Essas vantagens vão desde características da biologia, principalmente àquelas relacionadas ao pequeno porte, baixo custo de manutenção e curto período de gestação, até a semelhança com a placenta e o processo de placentação em humanos, uma vez que ambos possuem uma placenta discoidal, corioalantóidea e hemocorial, o que torna os roedores um interessante modelo experimental para o entendimento da placentação e mecanismos fisiológicos e moleculares de trocas materno-fetais (Carter 2007). Embora a grande maioria dessas características tenha permanecido estáveis ao longo da evolução dos roedores, trabalhos tem mostrado que pode haver variações relacionadas à presença de estruturas acessórias à placenta corioalantóidea, como é o caso da subplacenta nos roedores da Subordem Histricomorfa (Miglino et al, 2004, Bonatelli et al 2005, Oliveira et al 2006e 2012a e das características do saco vitelino, que nas diferentes espécies de roedores de um modo geral, forma uma placenta vitelina invertida ativa para trocas materno-fetais, presente até o final da gestação (Mossman 1987, Favaron et al 2011, 2012, Oliveira et al 2012a, 2012b.…”

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Dinâmica da inversão do saco vitelino em preás (Galea spixii Wagler, 1831)

et al. 2013

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Pesq. Vet. Bras. 33(8) The aim of this study was to study the time of yolk sac inversion as well as the dynamics resulting from this process in galea throughout pregnancy. For this, conventional histological techniques, scanning electron microscopy and transmission electron microscopy were used. Parietal and visceral endoderm delimiting the yolk sac cavity was observed at 12 days of pregnancy. The parietal endoderm was coating the fetal surface of the chorioallantoic placenta as well as delimiting the decidua capsularis area. This endoderm had prismatic format and were apart from the trophoblast by an enlarged Reichert's membrane. The visceral endoderm had vitelline vessels and there were villi only in certain areas. At 14 days of pregnancy the yolk sac inversion was characterized by the degeneration of parietal endoderm and mural trophoblast, and also the gradual disappearance of the Reichert's membrane. So it made the visceral endoderm establish an interface with the uterine epithelium. After the inversion, the parietal endoderm which remained intact was the one that rested on the chorioallantoic placenta surface. It presented cells with high columnar format and pseudostratified epithelium featured. The visceral endoderm presented many apical villi, especially in areas close to the chorioallantoic placenta. The continued development of the embryo and chorioallantoic placenta evidenced the emergence of an important apposition area between visceral and parietal endoderm. The yolk sac inversion represented an anatomical arrangement in favor of the embryo development as well as an evolutionary trait in this rodent species.INDEX TERMS: Galea, Galea spixii, yolk sac, visceral endoderm, parietal endoderm, inversion.

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Vascular Organization of the Hystricomorph Placenta: a Comparative Study in the Agouti, Capybara, Guinea Pig, Paca and Rock Cavy

Cited by 50 publications

References 19 publications

Development of the central nervous system in guinea pig (Cavia porcellus, Rodentia, Caviidae)

Development of the central nervous system in guinea pig (Cavia porcellus, Rodentia, Caviidae)

Descrição morfológica e morfométrica da glândula vesicular de cobaias durante o desenvolvimento pós-natal

Dinâmica da inversão do saco vitelino em preás (Galea spixii Wagler, 1831)

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