Vascular factor in erectile failure among diabetics

Jevtich, Milorad J.; Edson, Mitchell; Jarman, W. Dabney; Herrera, Hector

doi:10.1016/0090-4295(82)90573-8

Cited by 78 publications

(24 citation statements)

References 11 publications

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“…33,34 In addition to endothelial alterations, vascular smooth muscle cells appear to have a blunted response to NO. 15,35 Additionally, increased plasma and corporal body endothelin levels have been seen in diabetic men with ED. 36,37 This appears to be important in the pathogenesis of ED, as ET-1 is a key factor in maintaining corpus cavernosal smooth muscle tone.…”

Section: Diabetes Mellitusmentioning

confidence: 99%

Linking erectile dysfunction and coronary artery disease

2005

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Coronary artery disease (CAD) and erectile dysfunction (ED) are both highly prevalent conditions that frequently coexist. Additionally, they share mutual vascular risk factors, suggesting that they are both manifestations of systemic vascular disease. The role of endothelial dysfunction in CAD is well established. Normal erectile function is primarily a vascular event that relies heavily on endothelially derived, nitric oxide-induced vasodilation. Accordingly, endothelial dysfunction appears to be a common pathological etiology and mechanism of disease progression between CAD and ED. The risk factors of diabetes mellitus, hypertension, hyperlipidemia, obesity and tobacco abuse contribute to endothelial dysfunction. This article reviews the role of vascular endothelium in health, the abnormalities resulting from vascular risk factors, and clinical trials evaluating the role of endothelial dysfunction in ED.

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Section: Diabetes Mellitusmentioning

confidence: 99%

Linking erectile dysfunction and coronary artery disease

2005

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“…Adequate arterial inflow is necessary for erection, and cavernosal arterial morphology, flow (68), and diameter differ between diabetic and nondiabetic populations with ED. Overall, the preponderance of human studies suggests that neuropathy is the most important risk factor associated with ED in diabetes, leading to impaired NO signaling.…”

Section: Male Sexual Dysfunctionmentioning

confidence: 99%

Urologic Complications of Diabetes

et al. 2005

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“…The impact of neurogenic, psychogenic and vascular factors, usually combined, in the pathogenesis of related complications have been demonstrated in a large number of studies. [1][2][3][4][5][6] Numerous medical researches have shown that, prevalence of sexual dysfunction in men as a consequence of the degenerative effects of diabetes on vascular and neurogenic structures ranges from 35 to 75%. 1,[7][8][9][10][11][12] It has also been documented that the etiology of ED may be neurogenic in up to 82% of diabetic men.…”

Section: Introductionmentioning

confidence: 99%

Does sexual dysfunction correlate with deterioration of somatic sensory system in diabetic women?

et al. 2003

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To evaluate genital and extragenital somatic sensory system in diabetic women using biothesiometry and investigate the relation with sexual dysfunction. A total of 30 diabetic women and 20 normal sexually active women as a control group were evaluated with a detailed medical and sexual history including Index of Female Sexual Function (IFSF) questionnaire. Somatic sensory system of all women enrolled to the study was assessed by biothesiometry and threshold sensory values of nine genital sites and 14 extragenital sites were analyzed. The IFSF score in diabetic women was 23.6 while it was 38.3 in the control group (o0.0005). For each genital as well as extragenital sites, the mean biothesiometric values were significantly higher in diabetics. The sensation of introitus vagina, labium minora and clitoris were found to be the most deteriorated genital sites in diabetic women. The difference between diabetic women with or without female sexual dysfunction (FSD) was not significant for biothesiometric values. Our data indicate that, somatic sensory system is affected by diabetes however sexual dysfunction does not always manifest.

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Vascular factor in erectile failure among diabetics

Cited by 78 publications

References 11 publications

Linking erectile dysfunction and coronary artery disease

Linking erectile dysfunction and coronary artery disease

Urologic Complications of Diabetes

Does sexual dysfunction correlate with deterioration of somatic sensory system in diabetic women?

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