Linking erectile dysfunction and coronary artery disease

Rodriguez, Jennifer; Dashti, Raja; Schwarz, Ernst R.

doi:10.1038/sj.ijir.3901424

Cited by 42 publications

(32 citation statements)

References 79 publications

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“…Also, it is demonstrated that ED is an early symptom or harbinger of cardiovascular disease, owing to the Sexual dysfunction in women with coronary artery disease C Kaya et al common risk factors and pathophysiology mediated through endothelial dysfunction. 20 The present study revealed that two-thirds of women with proven CAD have FSD, which was considered comparable to the previous studies on SD and heart diseases.…”

Section: Discussionsupporting

confidence: 74%

Sexual function in women with coronary artery disease: a preliminary study

et al. 2006

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We investigated sexual function in female patients with coronary artery disease (CAD). A total of 20 consecutive female patients (38.273.8 years) with CAD diagnosed by coronary angiography and 15 healthy subjects (37.975.4 years) were enrolled in this study. The Female Sexual Function Index (FSFI) was used to assess sexual function in all the participants. Women with psychiatric disorders, gynecologic and systemic diseases that may affect sexual function were excluded from the study. The other exclusion criteria were usage of antidepressants and drugs affecting sexual function. Patients with CAD and healthy women were comparable in age, body mass index and education level. Female sexual dysfunction (FSD) was diagnosed in 12 of 20 women with CAD (60%), whereas five of 15 healthy women (33.3%) were found to have FSD (Po0.05). Patients with CAD had a significantly lower number of sexual intercourse episodes per month than healthy women volunteers (2.24 versus 5.2, respectively; Po0.05). The FSFI total score was clearly significantly decreased in the CAD group compared with that in healthy controls (17.872.9 and 26.074.8, P ¼ 0.001). When the subscores of each domain of FSFI were evaluated, all the subscores of FSFI, except the satisfaction domain, in patients with CAD were significantly lower than those of healthy subjects (Po0.05). This preliminary study demonstrates that female patients with CAD have distinct sexual dysfunction compared with healthy controls. Women with CAD should be evaluated also in terms of sexual function to provide better quality of life.

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Section: Discussionsupporting

confidence: 74%

Sexual function in women with coronary artery disease: a preliminary study

et al. 2006

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“…At the subcellular level, the underlying mechanism is based on the impaired bioavailability of nitric oxide (NO) that compromises normal NO-mediated vasodilatation. This condition favors vasoconstriction, deregulates intima proliferation, and promotes a proinflammatory environment that cause plaque destabilization (Rodriguez et al 2005). Endothelial dysfunction is thus considered a basic initiator in the formation of atheroma plaque (Marx and Grant 2007), and therefore, it precedes the clinical manifestations of atherosclerosis (Boneti et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Energy restriction ameliorates metabolic syndrome-induced cavernous tissue structural modifications in aged rats

Tomada

Fernandes

Guimarães

et al. 2012

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High-fat (HF) diet regular intake along life highly contributes to vascular dysfunction and to an increment in prevalence of metabolic syndrome (MetS) and erectile dysfunction (ED), a surrogate symptom of occult vascular disease, in the elderly. However, little is known about the effects of energy restriction (ER) alone/or after an HF-feeding period. We show here that in male Sprague-Dawley rats, 16 months of HF-diet consumption led to an increase in body adiposity, blood pressure, lipidemia, C-reactive protein, and insulin resistance and to hypoadiponectinemia, conditions that cluster in MetS. In addition, this treatment strongly favored collagen deposition in cavernous tissue and myocardium. Conversely, for the same time period, the ingestion of 75 % of ad libitum energy intake by controls (ER) extensively counteracted these outcomes. The impact of 6-month ER after 10-month HF period was also analyzed, and despite the decrease in body weight, adiposity, blood pressure, lipidemia, and Creactive protein and improvement of insulin sensitivity, no differences were observed either in adiponectin blood levels or in retroperitoneal fat pad mass. Moreover, this treatment led to a reduction in cavernous tissue collagen deposition, but not in the myocardium, and evidenced differential mobilization of adipose tissue accretions. The data show the ability of HF diet to cause MetS and produce unwanted effects on myocardium and corpora vascular structure. They also indicate that these consequences are preventable upon ER diet starting early, but not later, in life.

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“…Erectile dysfunction is a commonly under-diagnosed disease entity that shares common risk factors and pathophysiologic mechanisms with cardiovascular disease, 9 affecting approximately 30 million men in the United States. 10,11 One of the early studies to assess the prevalence of sexual dysfunction was Figure 4 Responses from male and female heart failure patients whether they are interested in treatment to improve their current sexual dysfunction.…”

Section: Sexual Dysfunction In Generalmentioning

confidence: 99%

The prevalence and clinical relevance of sexual dysfunction in women and men with chronic heart failure

et al. 2007

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Sexual dysfunction is a common problem of increasing incidence that is associated with multiple co-morbid conditions and chronic diseases. In heart failure, however, exact numbers are unknown, in part secondary to under-reporting and under-interrogating by health care providers. A genderspecific questionnaire was modified from established sexual dysfunction questionnaires to correspond to a non-randomized outpatient heart failure population, to assess the prevalence and demographic distribution of sexual dysfunction and potential treatments expectations. Onehundred patients in a stable hemodynamic condition in New York Heart Association classes I-III participated. Eighty-seven percent of women were diagnosed with female sexual dysfunction compared to 84% of men with erectile dysfunction. Eighty percent of women reported reduced lubrication, which resulted in frequent unsuccessful intercourse in 76%. Thirty-six percent of patients thought that sexual activity could harm their current cardiac condition; 75% of females and 60% of men stated that no physicians ever asked about potential sexual problems. Fifty-two percent of men considered sexual activity in their current condition as an essential aspect of quality of life and 61% were interested in treatment to improve sexual function. Sexual dysfunction appears to be high in prevalence in both men and women with chronic compensated heart failure and represents a reduction in quality of life for most. Despite the fact that most patients are interested in receiving therapy to improve sexual dysfunction, treatment options are rarely discussed or initiated.

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Linking erectile dysfunction and coronary artery disease

Cited by 42 publications

References 79 publications

Sexual function in women with coronary artery disease: a preliminary study

Sexual function in women with coronary artery disease: a preliminary study

Energy restriction ameliorates metabolic syndrome-induced cavernous tissue structural modifications in aged rats

The prevalence and clinical relevance of sexual dysfunction in women and men with chronic heart failure

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