Does sexual dysfunction correlate with deterioration of somatic sensory system in diabetic women?

Erol, Bülent; Tefekli̇, Ahmet; Şanlı, Öner; Ziylan, Orhan; Armağan, Abdullah; Kendirci, Muammer; Eryasar, D; Kadıoğlu, Ateş

doi:10.1038/sj.ijir.3900998

Cited by 74 publications

(68 citation statements)

References 24 publications

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“…Neuropathy, vascular impairment, and psychological complaints have been implicated in the pathogenesis of decreased libido, low arousability, decreased vaginal lubrication, orgasmic dysfunction, and dyspareunia among diabetic women. However, discrepancies exist between different reports (5,8,11). This could result, at least in part, from relatively small sample size, uncontrolled study design, or inaccurate characterization of diabetes.…”

Section: Diabetes Care 29:312-316 2006mentioning

confidence: 77%

Sexual Function and Endocrine Profile in Fertile Women With Type 1 Diabetes

et al. 2006

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OBJECTIVE -Aims of this study were 1) to assess sexual function and endocrine profile among fertile type 1 diabetic women during the follicular and luteal phases of the menstrual cycle, 2) to compare these results with those obtained among healthy fertile women who served as control subjects, and 3) to explore the correlations between sexual function and endocrine milieu among patients and control subjects during the follicular and luteal phases of the menstrual cycle.RESEARCH DESIGN AND METHODS -Fifty fertile women with type 1 diabetes and 47 healthy control subjects completed a semistructured medical interview and filled in selfadministered validated instruments to evaluate sexual function, depression, and sexual distress. Venous blood samples were drawn to measure glycated hemoglobin and an endocrine profile during either the follicular or the luteal phase of the menstrual cycle.RESULTS -Type 1 diabetic women had decreased sexual function and increased sexual distress compared with control subjects during the luteal, but not the follicular, phase of the menstrual cycle. During the follicular phase, patients had lower estrogenic basal tone, lower "weak" androgen (namely ⌬ 4 -androstenedione and dehydroepiandrosterone sulfate) production, and lower free-triiodothyronine and free-thyroxine levels compared with control subjects. During the luteal phase, total testosterone levels were higher in patients than control subjects, while 17␤-estradiol and progesterone levels were lower in patients than control subjects.CONCLUSIONS -Among type 1 diabetic women, sexual function and sexual distress vary according to the phase of the menstrual cycle. This finding may have implications on the clinical assessment of sexual function in type 1 diabetic women. Diabetes Care 29:312-316, 2006A lthough sexual disorders have been extensively studied in diabetic men (1-4), the sexual function of diabetic women has only recently received attention (4 -8). The prevalence of sexual dysfunction in diabetic men approaches 50%, whereas in diabetic women it seems to be slightly lower (5,9,10). Neuropathy, vascular impairment, and psychological complaints have been implicated in the pathogenesis of decreased libido, low arousability, decreased vaginal lubrication, orgasmic dysfunction, and dyspareunia among diabetic women. However, discrepancies exist between different reports (5,8,11). This could result, at least in part, from relatively small sample size, uncontrolled study design, or inaccurate characterization of diabetes. In fact, type 1 and type 2 diabetes seem to differently influence women's sexual function (5,6,12,13). To our knowledge, correlations between sexual function and endocrine profile and phase of the menstrual cycle in type 1 diabetic women have been scarcely investigated.Aims of the present study were 1) to assess sexual function and endocrine profile among fertile type 1 diabetic women during the follicular and luteal phase of the menstrual cycle, 2) to compare these results with those obtained among healthy fertile wom...

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Section: Diabetes Care 29:312-316 2006mentioning

confidence: 77%

Sexual Function and Endocrine Profile in Fertile Women With Type 1 Diabetes

et al. 2006

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“…Moreover, ED is an independent risk factor for new onset of cardiovascular disease and a powerful predictor of development of major cardiovascular events in diabetic patients with known coronary artery disease. 32,33 In contrast, FSD in women with type 1 diabetes seems for the most unrelated to cardiovascular risk factors: neuropathy, 34 vascular impairment 12 and psychological complaints 9,12 have been implicated in the pathogenesis of decreased libido, low arousability, decreased vaginal lubrication, orgasmic dysfunction and dyspaurenia among diabetic women. Even lees defined are the determinants of sexual function in type 2 diabetic women; according to the results of small studies 13,14,16,31 these determinants may include age, duration of diabetes, vascular complications and presence of menopause or psychological morbidity.…”

Section: Discussionmentioning

confidence: 99%

Determinants of female sexual dysfunction in type 2 diabetes

et al. 2010

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Studies assessing sexual dysfunction in type 2 diabetic women are scanty. This study was designed to evaluate the prevalence and correlates of female sexual function in a quite large population of diabetic women. A total of 595 women with type 2 diabetes completed a questionnaire of self-report measures of sexual dysfunction and were analyzed in this study. Their age was 57.9 ± 6.9 (mean and s.d.), duration of diabetes was 5.2 ± 1.5 years and mean hemoglobin A1c (HbA1c) level was 8.3±1.3%. Female sexual dysfunction (FSD) was assessed by the Female Sexual Function Index instrument with a cut-off score of 23. The overall prevalence of FSD among the diabetic women was 53.4%, significantly higher in menopausal women (63.9%), as compared with nonmenopausal women (41.0%, Po0.001). There was no association between HbA1c, duration of diabetes, hypertension, or cigarette smoking status and FSD; on the contrary, age, metabolic syndrome and atherogenic dyslipidemia were significantly associated with FSD. Both depression and marital status were independent predictors of FSD, while physical activity was protective. Further studies are needed to elucidate in full the mechanisms underlying the evident differences between male and female sexual function. In the meantime, evaluation of female sexuality should become a routine evaluation in women with type 2 diabetes, such as other diabetic complications.

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“…However, pertinent data in the few published studies are conflicting. 5,13,60,61 It has been hypothesized that hyperglycaemia, by reducing hydration of mucus membranes, including those in the vaginal tissue, results in poor vaginal lubrication and dyspareunia. 62 Also, hyperglycaemia may potentially lead to dyspareunia because of its association with an increased incidence of genitourinary infections.…”

Section: Pathogenesis Of Female Sexual Dysfunction In Diabetesmentioning

confidence: 99%

“…48,67 Moreover, in diabetic women a reduced vibration sense in their genitalia has been observed, but whether this symptom is related to sexual problems needs to be clarified. 60 Vascular changes or damage due to diabetes may lead to changes in the local blood flow and inhibition of the engorgement of the clitoris and lubrication of the vagina during arousal, resulting in dyspareunia or decreased arousal during sexual activity. 63,66 Additionally, the presence of diabetic neuropathy can have detrimental effects on the normal transduction of sexual stimuli as well as on the triggered sexual response 61,68 and may cause changes to the vaginal wall and pelvic floor dysfunction as a result of the weakened muscular tone.…”

Section: Pathogenesis Of Female Sexual Dysfunction In Diabetesmentioning

confidence: 99%