Vascular endothelial growth factor serum concentrations in hypercholesterolemic patients

Trapé, Jaume; Morales, Celina; Molina, Rafael; Filella, Xavier; Marcos, Josep; Salinas, Ramón; Franquesa, Josefina

doi:10.1080/00365510600564949

Cited by 26 publications

(15 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…52 Moreover, pDC depletion reduced vascular endothelium growth factor a potent angiogenic factor involved in vascular permeability, 53 the concentration of which increases in both serum and plaques during atherosclerosis. 39,40 Despite the cytokine-mediated effects of pDCs, through the release of IFN-α, having been implicated in a pathogenic T-cell response in human atherosclerotic plaques, 26 IFN-α was below the level of detection in both aortic tissue and serum samples in our apoE −/− mice irrespective of pDC depletion. This suggests that large increases in IFN-α production are not responsible for the pDC-mediated atherogenic effect in our experimental settings, although it is possible there are minor localized increases in expression, which the immunoassay could not detect.…”

Section: Discussionmentioning

confidence: 74%

“…We observed a >90% (P<0.05) decrease in IL-12, a proatherogenic cytokine in pDC-depleted mice in addition to decreases in the proatherogenic chemokines: KC (chemokine [C-X-C motif] ligand [CXCL] 1), monokine induced by IFN-γ/CXCL9, and IFN-γ−induced protein 10/CXCL10. Vascular endothelium growth factor, the concentration of which increases in both serum and plaques during atherosclerosis, 39,40 was found to be reduced by 75% (P<0.05) in pDC-depleted mice. Concentrations of fibroblast growth factor-basic, granulocyte-macrophage colony-stimulating factor, IFN-γ, IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-13, IL-17, monocyte chemoattractant protein-1, macrophage inflammatory protein-1α, and TNF-α did not differ significantly between groups or were below the level of detection (data not shown).…”

Section: Pdc Depletion Results In Systemic Reductions In Proatherosclmentioning

confidence: 90%

See 1 more Smart Citation

Plasmacytoid Dendritic Cells Play a Key Role in Promoting Atherosclerosis in Apolipoprotein E–Deficient Mice

MacRitchie

Grassia

Sabir

et al. 2012

ATVB

102

View full text Add to dashboard Cite

Objective-Clinical studies have identified that reduced numbers of circulating plasmacytoid dendritic cells (pDCs) act as a predictor of cardiovascular events in coronary artery disease and that pDCs are detectable in the shoulder region of human atherosclerotic plaques, where rupture is most likely to occur. Results from animal models are controversial, with pDCs seen to inhibit or promote lesion development depending on the experimental settings. Here, we investigated the role of pDCs in atherosclerosis in apolipoprotein E−deficient mice. Methods and Results-We demonstrated that the aorta and spleen of both apolipoprotein E−deficient and C57BL/6 mice displayed similar numbers of pDCs, with similar activation status. In contrast, assessment of antigen uptake/presentation using the Eα/Y-Ae system revealed that aortic pDCs in apolipoprotein E−deficient -mice were capable of presenting in vivo systemically administered antigen. Continuous treatment of apolipoprotein E−deficient mice with anti−mouse plasmacytoid dendritic cell antigen 1 (mPDCA-1) antibody caused specific depletion of pDCs in the aorta and spleen and significantly reduced atherosclerosis formation in the aortic sinus (by 46%; P<0.001). Depletion of pDCs also reduced macrophages (by 34%; P<0.05) and increased collagen content (by 41%; P<0.05) in aortic plaques, implying a more stable plaque phenotype. Additionally, pDC depletion reduced splenic T-cell activation and inhibited interleukin-12, chemokine (C-X-C motif) ligand 1, monokine induced by interferon-γ, interferon γ−induced protein 10, and vascular endothelium growth factor serum levels. Conclusion-These

show abstract

Section: Discussionmentioning

confidence: 74%

Section: Pdc Depletion Results In Systemic Reductions In Proatherosclmentioning

confidence: 90%

Plasmacytoid Dendritic Cells Play a Key Role in Promoting Atherosclerosis in Apolipoprotein E–Deficient Mice

MacRitchie

Grassia

Sabir

et al. 2012

ATVB

102

View full text Add to dashboard Cite

show abstract

“…Studies have shown a correlation between VEGF serum levels and the concentrations of cholesterol and triglycerides [29, 30], with high triglycerides and cholesterol associated with elevated VEGF, presumably due to endothelial damage. Therefore, we sought to determine whether lipid profiles differed in patients with high or low serum VEGF.…”

Section: Resultsmentioning

confidence: 99%

High Triglycerides Are Associated with Low Thrombocyte Counts and High VEGF in Nephropathia Epidemica

Martynova

Valiullina

Gusev

et al. 2016

Journal of Immunology Research

View full text Add to dashboard Cite

Nephropathia epidemica (NE) is a mild form of hemorrhagic fever with renal syndrome. Several reports have demonstrated a severe alteration in lipoprotein metabolism. However, little is known about changes in circulating lipids in NE. The objectives of this study were to evaluate changes in serum total cholesterol, high density cholesterol (HDCL), and triglycerides. In addition to evaluation of serum cytokine activation associations, changes in lipid profile and cytokine activation were determined for gender, thrombocyte counts, and VEGF. Elevated levels of triglycerides and decreased HDCL were observed in NE, while total cholesterol did not differ from controls. High triglycerides were associated with both the lowest thrombocyte counts and high serum VEGF, as well as a high severity score. Additionally, there were higher levels of triglycerides in male than female NE patients. Low triglycerides were associated with upregulation of IFN-γ and IL-12, suggesting activation of Th1 helper cells. Furthermore, levels of IFN-γ and IL-12 were increased in patients with lower severity scores, suggesting that a Th1 type immune response is playing protective role in NE. These combined data advance the understanding of NE pathogenesis and indicate a role for high triglycerides in disease severity.

show abstract

“…There is a relationship between hypercholesterolemia and serum level of VEGF31. The endothelial replication necessary for vascular growth is markedly impaired in the presence of hypercholesterolemia32.…”

Section: Introductionmentioning

confidence: 99%

Diseases having an influence on inhibition of angiogenesis as risk factors of osteonecrosis of the jaw

Paek

Park

Shin

et al. 2016

J Korean Assoc Oral Maxillofac Surg

View full text Add to dashboard Cite

ObjectivesThe objective of this study was to retrospectively investigate the association of diseases having an influence on inhibition of angiogenesis such as hypertension, diabetes mellitus type II, hypercholesterolemia, and rheumatoid arthritis (RA) with the development of osteonecrosis of the jaws.Materials and MethodsThe 135 patients were allocated into 4 groups of bisphosphonate-related osteonecrosis of the jaw (BRONJ) group (1A); non-BRONJ group (1B); osteonecrosis of the jaw (ONJ) group (2A); and control group (2B), according to histologic results and use of bisphosphonate. This retrospective study was conducted with patients who were treated in one institute from 2012 to 2013. Fisher's exact test and logistic regression analysis were used to analyze the odds ratios of diseases having an influence on inhibition of angiogenesis for development of ONJ.ResultsThe effects of diabetes and hypertension were not statistically significant on development of ONJ. When not considering bisphosphonate use, RA exhibited a high odds ratio of 3.23 (P=0.094), while hyperlipidemia showed an odds ratio of 2.10 (P=0.144) for development of ONJ. More than one disease that had an influence on inhibition of angiogenesis showed a statistically significant odds ratio of 2.54 (P=0.012) for development of ONJ.ConclusionPatients without diseases having an influence on inhibition of angiogenesis were at less risk for developing ONJ.

show abstract

Vascular endothelial growth factor serum concentrations in hypercholesterolemic patients

Abstract: A relationship was found between serum levels of VEGF and most atherogenic lipoproteins. In patients with hypercholesterolemia treated with pravastatin, a reduction in VEGF and CRP was seen in addition to lipid decreases.

Cited by 26 publications

References 23 publications

Plasmacytoid Dendritic Cells Play a Key Role in Promoting Atherosclerosis in Apolipoprotein E–Deficient Mice

Plasmacytoid Dendritic Cells Play a Key Role in Promoting Atherosclerosis in Apolipoprotein E–Deficient Mice

High Triglycerides Are Associated with Low Thrombocyte Counts and High VEGF in Nephropathia Epidemica

Diseases having an influence on inhibition of angiogenesis as risk factors of osteonecrosis of the jaw

Contact Info

Product

Resources

About