High Triglycerides Are Associated with Low Thrombocyte Counts and High VEGF in Nephropathia Epidemica

Martynova, Ekaterina; Valiullina, A.; Gusev, Oleg; Davidyuk, Yuriy; Garanina, Ekaterina; Shakirova, Venera; Хаертынова, И. М.; Анохин, В. А.; Rizvanov, Albert A.; Khaiboullina, Svetlana F.

doi:10.1155/2016/8528270

Cited by 7 publications

(6 citation statements)

References 41 publications

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“…We found also that LDCL1 and HDCL1 have positive and negative associations with PC1 cytokines, respectively. Changes in the serum level of lipids have been demonstrated in hantavirus-infected patients [2,66,67]. Our results provide more data contributing to the understanding of the role of lipids in pathogenesis of NE.…”

Section: Discussionsupporting

confidence: 60%

Serum Cytokine Alterations Associated with Age of Patients with Nephropathia Epidemica

Shakirova

Khaertynova

Markelova

et al. 2022

BioMed Research International

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Nephropathia epidemica (NE) is a zoonotic disease caused by hantaviruses transmitted from rodents, endemic in the Republic of Tatarstan, Russia. The disease presents clinically with mild, moderate, and severe forms, and time-dependent febrile, oliguric, and polyuric stages of the disease are also recognized. The patient’s cytokine responses have been suggested to play a central role in disease pathogenesis; however, little is known about the different patterns of cytokine expression in NE in cohorts of different ages and sexes. Serum samples and clinical records were collected from 139 patients and 57 controls (healthy donors) and were used to analyze 48 analytes with the Bio-Plex multiplex magnetic bead-based antibody detection kits. Principal component analysis of 137 patient and 55 controls (for which there was full data) identified two components that individually accounted for >15% of the total variance in results and together for 38% of the total variance. PC1 represented a proinflammatory TH17/TH2 cell antiviral cytokine profile and PC2 a more antiviral cytokine profile with patients tending to display one or the other of these. Severity of disease and stage of illness did not show any correlation with PC1 profiles; however, significant differences were seen in patients with high PC1 profiles vs. lower for a number of individual clinical parameters: High PC1 patients showed a reduced number of febrile days, but higher maximum urine output, higher creatinine levels, and lower platelet levels. Overall, the results of this study point towards a stronger proinflammatory profile occurring in younger NE patients, this being associated with markers of acute kidney injury and low levels of high-density cholesterol. This is consistent with previous work indicating that the pathology of NE is immune driven, with an inflammatory immune response being associated with disease and that this immune response is more extreme in younger patients.

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Section: Discussionsupporting

confidence: 60%

Serum Cytokine Alterations Associated with Age of Patients with Nephropathia Epidemica

Shakirova

Khaertynova

Markelova

et al. 2022

BioMed Research International

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“…In my study, we found that there was a significant and positive correlation between VEGF with TG, the high TG concentration, so the high VEGF concentration too in my study, we found that there was no significant correlation between VEGF and cholesterol total, LDL, and HDL. Like research by Martynova et al reported that high TGs were associated with high serum VEGF [14]. However, different research by Sun et al that there were no significant relationships between VEGF and any of the following factors such as sex, age, BMI, HbA1c, FBG, TG, TC, HDL-C, and LDL-C at type 2 DM [15].…”

Section: Discussionmentioning

confidence: 87%

The Correlation between Serum Vascular Endothelial Growth Factor and Lipid Profile in Type 2 Diabetes Mellitus

Rusdiana

Widjaja

Amelia

2020

Open Access Maced J Med Sci

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BACKGROUND: Diabetes mellitus is a chronic metabolic disease characterized by increased blood sugar levels (BSLs). Elevated BSL was to be reliably measured by measuring the concentration of hemoglobin glycosylate (HbA1C). Chronic hyperglycemia can result in damage to endothelial cells resulting in disruption of vascular hemostasis leading to complications in the form of vascular disorders. Endothelial damage or dysfunction will increase cytokines, one of which is vascular endothelial growth factor (VEGF), which induces angiogenesis. AIM: In our study we wanted to investigate the correlation between serums VEGF with lipid profile at type 2 diabetes mellitus patients in primary health care in Medan city of North Sumatera, Indonesia. MATERIALS AND METHODS: This study conducted at type 2 diabetes mellitus with the cross-sectional analytic method. The inclusion criteria of the samples were all the patients diagnosed with type 2 diabetes mellitus, both the sexes. Body mass index (BMI), blood pressure, duration of disease, and family history were recorded. The laboratory parameters, including fasting blood sugar, HbA1c, high-density lipoprotein, low-density lipoprotein, triglycerides (TG), and cholesterol, were examined by Paramita Laboratory Clinic and VEGF and hypoxia-inducible factor (HIF)-1α, we examined by ELISA methods in the laboratory Medical Faculty, Universitas Sumatera Utara. The data of the samples were processed using a computer with the SPSS program. RESULTS: There was a significant correlation between VEGF and BMI, TG, and HIF-1α. The statistical analysis using correlation test found that there was a significant correlation between VEGF and BMI, TG, HIF-1α _type 2 diabetes mellitus patients (p < 0.005). CONCLUSION: Therefore, our study showed that the correlation between VEGF and lipid profile (TG), BMI, and HIF-1α _was a positive correlation, which showed a directional relationship, if the VEGF level is high then the BMI, TG and HIF-1α _values are also high.

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“…A previous study revealed that VEGF-A expression alone initially leads to vessel enlargement followed by a loss of pericytes [ 19 ]. A high cholesterol diet might increase the expression of serum VEGF-A in nephropathia epidemica [ 20 ]. Our study indicated that VEGF-A and VEGFR-2 expression levels dramatically increased from week 4 to 12, and the correlation between LDL-C and VEGF-A/VEGFR-2 was positive.…”

Section: Discussionmentioning

confidence: 99%

VEGF-A/VEGFR-2 and FGF-2/FGFR-1 but not PDGF-BB/PDGFR-β play important roles in promoting immature and inflammatory intraplaque angiogenesis

et al. 2018

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Various angiogenic factors have been shown to play important roles in intraplaque angiogenesis, while little is known about the dynamic expression change and interplay between various angiogenic factors and intraplaque angiogenesis under high cholesterol conditions. New Zealand rabbits underwent balloon injury of the abdominal artery and then were assigned to a control group (n = 15, normal chow) or high cholesterol group (n = 25, 1% high cholesterol diet). At weeks 4, 6, 8, 10, and 12 after acclimation, rabbits (high cholesterol group, n = 5; control group, n = 3) were euthanized. No lesions were observed in the control group. From week 4 to week 12, the expression of vascular endothelial growth factor A (VEGF-A), VEGF receptor 2 (VEGFR-2), fibroblast growth factor 2 (FGF-2), FGF receptor 1 (FGFR-1), platelet-derived growth factor-BB (PDGF-BB), and tumor necrosis factor alpha (TNF-α), the vulnerability index (VI) and the microvessel density (MVD) were significantly elevated in the high cholesterol group; however, PDGF receptor β (PDGFR-β) expression showed little change. Analysis by double-label immunofluorescence (CD31 and Ng2) and FITC-dextran indicated that the neovessels within the plaque were leaky due to a lack of pericytes. As indicated by Pearson’s correlation analysis, there was a highly positive correlation between the VI, MVD, macrophage content, and TNF-α level, and the levels of VEGF-A/VEGFR-2 and FGF-2/FGFR-1. However, no correlations were observed between PDGFR-β levels and the VI or MVD. High expression of VEGF-A/VEGFR-2 and FGF-2/FGFR-1 but not of PDGF-BB/PDGFR-β may contribute to immature and inflammatory intraplaque angiogenesis and plaque instability in a rabbit model of atherosclerosis.

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High Triglycerides Are Associated with Low Thrombocyte Counts and High VEGF in Nephropathia Epidemica

Cited by 7 publications

References 41 publications

Serum Cytokine Alterations Associated with Age of Patients with Nephropathia Epidemica

Serum Cytokine Alterations Associated with Age of Patients with Nephropathia Epidemica

The Correlation between Serum Vascular Endothelial Growth Factor and Lipid Profile in Type 2 Diabetes Mellitus

VEGF-A/VEGFR-2 and FGF-2/FGFR-1 but not PDGF-BB/PDGFR-β play important roles in promoting immature and inflammatory intraplaque angiogenesis

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