The Correlation between Serum Vascular Endothelial Growth Factor and Lipid Profile in Type 2 Diabetes Mellitus

Abstract

BACKGROUND: Diabetes mellitus is a chronic metabolic disease characterized by increased blood sugar levels (BSLs). Elevated BSL was to be reliably measured by measuring the concentration of hemoglobin glycosylate (HbA1C). Chronic hyperglycemia can result in damage to endothelial cells resulting in disruption of vascular hemostasis leading to complications in the form of vascular disorders. Endothelial damage or dysfunction will increase cytokines, one of which is vascular endothelial growth factor (VEGF), which induces angiogenesis. 
 AIM: In our study we wanted to investigate the correlation between serums VEGF with lipid profile at type 2 diabetes mellitus patients in primary health care in Medan city of North Sumatera, Indonesia.
 MATERIALS AND METHODS: This study conducted at type 2 diabetes mellitus with the cross-sectional analytic method. The inclusion criteria of the samples were all the patients diagnosed with type 2 diabetes mellitus, both the sexes. Body mass index (BMI), blood pressure, duration of disease, and family history were recorded. The laboratory parameters, including fasting blood sugar, HbA1c, high-density lipoprotein, low-density lipoprotein, triglycerides (TG), and cholesterol, were examined by Paramita Laboratory Clinic and VEGF and hypoxia-inducible factor (HIF)-1α, we examined by ELISA methods in the laboratory Medical Faculty, Universitas Sumatera Utara. The data of the samples were processed using a computer with the SPSS program.
 RESULTS: There was a significant correlation between VEGF and BMI, TG, and HIF-1α. The statistical analysis using correlation test found that there was a significant correlation between VEGF and BMI, TG, HIF-1α _type 2 diabetes mellitus patients (p < 0.005).
 CONCLUSION: Therefore, our study showed that the correlation between VEGF and lipid profile (TG), BMI, and HIF-1α _was a positive correlation, which showed a directional relationship, if the VEGF level is high then the BMI, TG and HIF-1α _values are also high.

Oxidative Stress regulates glycogen synthase kinase-3 in Lymphocytes of Diabetes Mellitus Patients with cerebral infarction

“…The incidence of DM with cerebral infarction has been on the rise with the higher incidence of DM [19]. Patients with DM are in a state of hyperglycemia for a long time, and blood lipids and glucose levels are increased signi cantly, resulting in cerebral vasculopathy and hemodynamic abnormalities, leading to atherosclerosis, and then developing cerebral infarction [20,21]. Almost 60% to 70% of patients with DM, whether they have complications, have lipid metabolism disorders, which may be a risk factor for diabetes mellitus [22].…”

Prospects of potential adipokines as therapeutic agents in obesity-linked atherogenic dyslipidemia and insulin resistance

“…During obesity, VEGF secretion increases in an insulin-dependent manner [ 49 ]. VEGF levels also rise during the expansion of vascular adipose tissue (VAT) [ 50 , 51 ] . VEGF-A improves vascularization and turns white adipose tissue (WAT) to brown adipose tissue (BAT).…”