Vascular endothelial growth factor in allergen‐induced nasal inflammation

Gs, Choi; Park, Hae‐Sim; Gy, Hur; Sj, Choi; Sy, Shin; Ym, Ye

doi:10.1111/j.1365-2222.2009.03216.x

Cited by 23 publications

(26 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…After the nasal exposure to allergen, infiltration of inflammatory cells, such as activated eosinophils and Th2 cells, into the nasal mucosa is induced by cytokines, chemical mediators, chemokines and growth factors [18,19]. Cytokines such as IL-5, IL-4, IL-13 and granulocyte-macrophage colonystimulating factor (GM-CSF) are produced mainly in Th2 cells and mast cells; however, eosinophils also have the potential to produce these cytokines [18,20,21].…”

Section: Introductionmentioning

confidence: 99%

Mechanisms and clinical implications of glucocorticosteroids in the treatment of allergic rhinitis

Okano

2009

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SummaryAllergic rhinitis is a common airway disease characterized by hypersensitivity, exudation, hypersecretion, inflammatory cell infiltration and remodelling. Intranasal glucocorticosteroids are the most effective drugs for controlling the inflammation caused by allergic rhinitis. Glucocorticosteroids exert anti-inflammatory effects through at least two pathways: the transactivation pathway and the transrepression pathway. Glucocorticosteroids also exert regulatory functions by inducing regulatory cytokines and forkhead box P3 (FoxP3 + ) regulatory T cells. Evidence suggests that intranasal glucocorticosteroids control not only nasal symptoms but also ocular symptoms. In contrast to sedating H1 receptor antagonists, intranasal glucocorticosteroids can improve impaired performance symptoms, such as daytime sleepiness, associated with allergic rhinitis. Recent studies suggest that intranasal glucocorticosteroids might also be useful for the prophylactic treatment of pollinosis; this possibility is supported by the molecular mechanism of the anti-inflammatory action of glucocorticosteroids. These findings suggest that intranasal glucocorticosteroids might be positioned as first-line drugs for the treatment of both perennial and seasonal allergic rhinitis.

show abstract

Section: Introductionmentioning

confidence: 99%

Mechanisms and clinical implications of glucocorticosteroids in the treatment of allergic rhinitis

Okano

2009

Clinical and Experimental Immunology

View full text Add to dashboard Cite

show abstract

“…Although the clinical implications remain obscure, elevated levels of beta-lactoglobulin-specific serum IgA and IgG4 have been associated with cow's milk allergy [40] . Increased IgA levels have also been observed in the nasal lavage fluid of patients with allergic rhinitis [41] . IL-3 stimulates the release of large quantities of histamine, LTC4, IL-4, and IL-13 from basophils [42] .…”

Section: Molecular Messengers Of Allergymentioning

confidence: 95%

Mast cells and basophils are essential for allergies: mechanisms of allergic inflammation and a proposed procedure for diagnosis

Zhang

Zeng

et al. 2013

Acta Pharmacol Sin

View full text Add to dashboard Cite

The current definition of allergy is a group of IgE-mediated diseases. However, a large portion of patients with clinical manifestations of allergies do not exhibit elevated serum levels of IgE (sIgEs). In this article, three key factors, ie soluble allergens, sIgEs and mast cells or basophils, representing the causative factors, messengers and primary effector cells in allergic inflammation, respectively, were discussed. Based on current knowledge on allergic diseases, we propose that allergic diseases are a group of diseases mediated through activated mast cells and/or basophils in sensitive individuals, and allergic diseases include four subgroups: (1) IgE dependent; (2) other immunoglobulin dependent; (3) non-immunoglobulin mediated; (4) mixture of the first three subgroups. According to our proposed definition, pseudo-allergic-reactions, in which mast cell or basophil activation is not mediated via IgE, or to a lesser extent via IgG or IgM, should be non-IgE-mediated allergic diseases. Specific allergen challenge tests (SACTs) are gold standard tests for diagnosing allergies in vivo, but risky. The identification of surface membrane activation markers of mast cells and basophils (CD203c, CCR3, CD63, etc) has led to development of the basophil activation test (BAT), an in vitro specific allergen challenge test (SACT). Based on currently available laboratory allergy tests, we here propose a laboratory examination procedure for allergy.

show abstract

“…These studies suggest that innate immunity agonists such as poly(I:C) can be used to activate the RLH pathway and control VEGF tissue responses in diseases such as asthma. Elevated levels of VEGF are also believed to be involved in the pathogenesis of a variety of other diseases including tumor angiogenesis, rheumatoid arthritis, inflammatory bowel disease, psoriasis, allergic rhinitis, and wet macular degeneration (3,(57)(58)(59)(60)(61). Thus, it is tempting to speculate that poly(I:C) and/or other RLH agonists can be used to treat these disorders as well.…”

Section: Discussionmentioning

confidence: 99%

RIG-like Helicase Innate Immunity Inhibits Vascular Endothelial Growth Factor Tissue Responses via a Type I IFN–dependent Mechanism

Cruz²,

Hartl³

et al. 2011

Am J Respir Crit Care Med

View full text Add to dashboard Cite

Vascular endothelial growth factor in allergen‐induced nasal inflammation

Abstract: Nasal VEGF secretion in response to allergen exposure may augment eosinophilic inflammation in the nasal mucosa of patients with AR.

Cited by 23 publications

References 34 publications

Mechanisms and clinical implications of glucocorticosteroids in the treatment of allergic rhinitis

Mechanisms and clinical implications of glucocorticosteroids in the treatment of allergic rhinitis

Mast cells and basophils are essential for allergies: mechanisms of allergic inflammation and a proposed procedure for diagnosis

RIG-like Helicase Innate Immunity Inhibits Vascular Endothelial Growth Factor Tissue Responses via a Type I IFN–dependent Mechanism

Contact Info

Product

Resources

About