Mast cells and basophils are essential for allergies: mechanisms of allergic inflammation and a proposed procedure for diagnosis

He, Shaoheng; Zhang, Huiyun; Zeng, Xianlu; Chen, Dong; Yang, Ping‐Chang

doi:10.1038/aps.2013.88

Cited by 83 publications

(71 citation statements)

References 150 publications

(196 reference statements)

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“…Histamine is the major mediator of the immediate allergic reaction. Allergic rhinitis is accompanied by the release of histamine from granules in sensitized mast cells or gut basophils . Endogenous histamine is formed in the body from the amino acid histidine via decarboxylation.…”

Section: Discussionmentioning

confidence: 99%

Gut microbial‐derived butyrate is inversely associated with IgE responses to allergens in childhood asthma

Chiu

Cheng

Chiang

et al. 2019

Pediatric Allergy Immunology

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Background A comprehensive metabolomics‐based approach to address the impact of specific gut microbiota on allergen sensitization for childhood rhinitis and asthma is still lacking. Methods Eighty‐five children with rhinitis (n = 27) and with asthma (n = 34) and healthy controls (n = 24) were enrolled. Fecal metabolomic analysis with 1H‐nuclear magnetic resonance (NMR) spectroscopy and microbiome composition analysis by bacterial 16S rRNA sequencing were performed. An integrative analysis of their associations with allergen‐specific IgE levels for allergic rhinitis and asthma was also assessed. Results Amino acid, β‐alanine, and butanoate were the predominant metabolic pathways in the gut. Among them, amino acid metabolism was negatively correlated with the phylum Firmicutes, which was significantly reduced in children with rhinitis and asthma. Levels of histidine and butyrate metabolites were significantly reduced in children with rhinitis (P = 0.029) and asthma (P = 0.009), respectively. In children with asthma, a reduction in butyrate‐producing bacteria, including Faecalibacterium and Roseburia spp., and an increase in Clostridium spp. were negatively correlated with fecal amino acids and butyrate, respectively (P < 0.01). Increased Escherichia spp. accompanied by increased β‐alanine and 4‐hydroxybutyrate appeared to reduce butyrate production. Low fecal butyrate was significantly associated with increased total serum and mite allergen–specific IgE levels in children with asthma (P < 0.05). Conclusion A reduced fecal butyrate is associated with increased mite‐specific IgE levels and the risk of asthma in early childhood. Fecal β‐alanine could be a specific biomarker connecting the metabolic dysbiosis of gut microbiota, Clostridium and Escherichia spp., in childhood asthma.

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Section: Discussionmentioning

confidence: 99%

Gut microbial‐derived butyrate is inversely associated with IgE responses to allergens in childhood asthma

Chiu

Cheng

Chiang

et al. 2019

Pediatric Allergy Immunology

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“…Here, the expression of inside-outside markers is used to determine degranulation (CD63, CD69, CD203c, CCR3) (162,163).…”

Section: Response To Environmental Challengementioning

confidence: 99%

Current and future biomarkers in allergic asthma

Zissler

Bieren

Jakwerth

et al. 2016

Allergy

102

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Diagnosis early in life, sensitization, asthma endotypes, monitoring of disease and treatment progression are key motivations for the exploration of biomarkers for allergic rhinitis and allergic asthma. The number of genes related to allergic rhinitis and allergic asthma increases steadily; however, prognostic genes have not yet entered clinical application. We hypothesize that the combination of multiple genes may generate biomarkers with prognostic potential. The current review attempts to group more than 161 different potential biomarkers involved in respiratory inflammation to pave the way for future classifiers. The potential biomarkers are categorized into either epithelial or infiltrate-derived or mixed origin, epithelial biomarkers. Furthermore, surface markers were grouped into cell-typespecific categories. The current literature provides multiple biomarkers for potential asthma endotypes that are related to T-cell phenotypes such as Th1, Th2, Th9, Th17, Th22 and Tregs and their lead cytokines. Eosinophilic and neutrophilic asthma endotypes are also classified by epithelium-derived CCL-26 and osteopontin, respectively. There are currently about 20 epithelium-derived biomarkers exclusively derived from epithelium, which are likely to innovate biomarker panels as they are easy to sample. This article systematically reviews and categorizes genes and collects current evidence that may promote these biomarkers to become part of allergic rhinitis or allergic asthma classifiers with high prognostic value.

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“…Indeed, pseudoallergy and anaphylaxis are clinically indistinguishable [5]. The signs and symptoms of pseudoallergy are practically identical to IgE-mediated symptoms including angioedema, urticaria, bronchospasm and gastrointestinal signs [6,7], together with skin flushing, headache, edema, hypotension and shock [8].…”

Section: Introductionmentioning

confidence: 99%

Drug-Induced Pseudoallergy: A Review of the Causes and Mechanisms

Zhang

Li²,

Shi³

et al. 2017

Pharmacology

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Adverse drug reactions occur frequently and can trigger pseudoallergy, which has become a serious threat to public health. Pseudoallergy is a typical non-immune anaphylactic reaction characterized by the independence of antigen-specific immune responses. In the clinic, pseudoallergy is often elicited by the first dose of medication, and here lies its unpredictability and occasional lethal outcome. However, the mechanisms of pseudoallergy are not well understood. This review focusses on the causes and mechanisms of pseudoallergy induced by drugs. Two categories of mechanisms will be considered, namely, (1) complement activation-related pseudoallergy and (2) mast cell activation-related pseudoallergy. The factors that induce pseudoallergy include opioid drugs, complement activation-related pseudoallergenic drugs, nonsteroidal anti-inflammatory drugs and traditional Chinese medicine injections.

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Mast cells and basophils are essential for allergies: mechanisms of allergic inflammation and a proposed procedure for diagnosis

Cited by 83 publications

References 150 publications

Gut microbial‐derived butyrate is inversely associated with IgE responses to allergens in childhood asthma

Gut microbial‐derived butyrate is inversely associated with IgE responses to allergens in childhood asthma

Current and future biomarkers in allergic asthma

Drug-Induced Pseudoallergy: A Review of the Causes and Mechanisms

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