Vascular endothelial growth factor gene polymorphisms and idiopathic recurrent pregnancy loss

Papazoglou, Dimitrios; Γαλάζιος, Γεώργιος; Παπαθεοδώρου, Κωνσταντίνος; Liberis, V.; Παπάνας, Νικόλαος; Maltezos, Efstratios; Maroulis, Georgios

doi:10.1016/j.fertnstert.2004.12.017

Cited by 75 publications

(104 citation statements)

References 44 publications

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“…It was in agreement with the previous studies in Greek, American and Indian populations (19,28,32,33). It seems that the presence of allele (A) at +1154 produces the possibly of insuffi cient VEGF level because of low gene expression (34,35).…”

Section: Discussionsupporting

confidence: 92%

“…The lack of the association with RSA and +936C/T (rs3025039, 3´UTR region) in the current study was also reported in Bahraini (Brazilian, 27), Greek (28) and Korean (29) population studies while Aggarwal et al (19) studied North Indians and it was in disagreement with previous studies and our fi ndings. In the present study, we did not report +936 T allele frequency of both case and controls.…”

Section: Discussioncontrasting

confidence: 92%

“…In the present study, we did not report +936 T allele frequency of both case and controls. Homozygosity for this allele is also rare (0.8-4 %) in different populations (19,28). The +936C/T SNP is located in 3´UTR region and was linked to altered VEGF expression in different studies (12, 30, 31).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Genetic variation in vascular endothelial growth factor gene and its association with recurrent spontaneous abortion

Saboori¹,

Noormohammadi²,

Zare-Karizi³

2016

BLL

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 92%

See 1 more Smart Citation

Genetic variation in vascular endothelial growth factor gene and its association with recurrent spontaneous abortion

Saboori¹,

Noormohammadi²,

Zare-Karizi³

2016

BLL

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“…Endometriosis and hydrosalpinx may influence both endometrial receptivity and implantation [27]. Furthermore, it has been suggested that the abnormal maternal expression of genes associated with angiogenesis, immunity and apoptosis interferes with successful implantation [13,30,37].…”

Section: Introductionmentioning

confidence: 99%

“…An association between VEGF −1154 G/A polymorphism and RIF after IVF-ET has been evidenced [13,30]. Furthermore, the C allele of +405 G/C has been proposed as a candidate SNP associated with the pathogenesis of several female reproductive tract diseases, such as pre-eclampsia [2], endometriosis [11], recurrent pregnancy loss [7] and ovarian hyperstimulation syndrome following controlled ovarian hyperstimulation [15].…”

Section: Introductionmentioning

confidence: 99%

The vascular endothelial growth factor (VEGF) +405 G/C polymorphism and its relationship with recurrent implantation failure in women in an IVF programme with ICSI

Boudjenah

Molina-Gomès

Wainer

et al. 2012

J Assist Reprod Genet

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Purpose Successful embryo implantation depends on trophoblast proliferation, migration and, lastly, invasion of the endometrium (to anchor the trophoblast to the uterus). This invasion is mediated by locally produced soluble factors. Of these, vascular endothelial growth factor (VEGF) is the best characterized regulator of angiogenesis. Here, we investigate the association between the VEGF+405 C/G genotype and the recurrence of embryo implantation failure in women undergoing in vitro fertilization (IVF) program with intracytoplasmic sperm injection (ICSI). Methods Forty women with recurrent implantation failure defined by absence of pregnancy after transfer of more than 10 embryos and 131 women control, with at least one live birth after the transfer of fewer than 10 embryos were included. Genomic DNA was analysed with an allele-specific polymerase chain reaction and a Chi-2 test was used to compare the respective VEGF+405 C/G genotype frequencies in cases and controls. Results The frequency of the VEGF +405C/C genotype was higher in women with recurrent implantation failure after ICSI-embryo transfer than in controls (17.5 % and 5.3 %, respectively, p00.01). Conclusion The VEGF +405 G/C polymorphism may influence embryo implantation and VEGF+405 C/C genotype may predispose to recurrent implantation failure after ICSI-ET.

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Maternal candidate gene variants, epigenetic factors, and susceptibility to idiopathic recurrent pregnancy loss: A systematic review

Kaur

Chhabra³

et al. 2023

Intl J Gynecology & Obste

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BackgroundRecurrent pregnancy loss is defined as the loss of two or more pregnancies and is a distressing condition for couples.ObjectiveTo investigate the relationship between variants in the candidate susceptibility genes and epigenetic factors to identify risk factors for idiopathic recurrent pregnancy loss (iRPL).Search StrategyA systematic literature search was performed using PubMed, Google Scholar, ScienceDirect, and Scopus databases. Insilico analysis was carried out using ShinyGO and STRING software.Selection CriteriaResearch papers examining the association between variations in genetic and epigenetic factors and iRPL.Data Collection and AnalysisData were independently extracted by two authors.Main ResultsIn total, 83 research papers were finally selected for the present study. Among all the genes involved in the pathogenesis of recurrent pregnancy loss, polymorphisms in IL superfamily genes, VEGF, ESR, and MTHFR were the most investigated.ConclusionPolymorphisms in angiogenesis, immune tolerance, and thrombophilia pathway genes, which occur independently or synergistically, may lead to various complications during fetal development. Identification of multi‐allele risk variants and epigenetic factors in women will be helpful in the identification of high‐risk pregnancies.Prospero Registration NumberProspero CRD42021287315.

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Vascular endothelial growth factor gene polymorphisms and idiopathic recurrent pregnancy loss

Abstract: This is the first report on VEGF gene polymorphisms in women with recurrent miscarriage, demonstrating that the -1154G/A VEGF gene polymorphism is associated with idiopathic recurrent abortions.

Cited by 75 publications

References 44 publications

Genetic variation in vascular endothelial growth factor gene and its association with recurrent spontaneous abortion

Genetic variation in vascular endothelial growth factor gene and its association with recurrent spontaneous abortion

The vascular endothelial growth factor (VEGF) +405 G/C polymorphism and its relationship with recurrent implantation failure in women in an IVF programme with ICSI

Maternal candidate gene variants, epigenetic factors, and susceptibility to idiopathic recurrent pregnancy loss: A systematic review

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