Vascular endothelial growth factor, basic fibroblast growth factor, insulin-like growth factor-I and platelet-derived growth factor levels in human milk of mothers with term and preterm neonates

Özgürtaş, Taner; Aydın, İbrahim; Turan, Özden; Koç, Esin; Hırfanoğlu, İbrahim Murat; Açıkel, Cengiz Han; Akyol, Mesut; Erbil, M.

doi:10.1016/j.cyto.2010.02.008

Cited by 28 publications

(23 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our data are consistent with the data of other researchers [7,12,14,22,24,29], who also demonstrated the presence of IGF-1, leptin, ghrelin and adiponectin in breast milk and confirm their hypothesis that these breast milk proteins can play a role in the regulation of feeding behavior and energy homeostasis of breast-fed infants. Indeed, in our study, the infants in the high weight gain group, who were fed with breast milk with high hormone levels, consumed significantly more breast milk than the infants with low weight gain and had the highest growth rate.…”

Section: Discussionsupporting

confidence: 82%

“…Milson et al [12] and Blum and Baumrucker [16] speculated that high early levels of the human milk IGF system contribute to the maturation of the infant gut. The majority of authors consider that breast milk IGF-1 can influence regulatory functions and growth of neonatal tissues in a direct or indirect way [12,14,16]. In our study, we also observed a positive correlation between the breast milk IGF-1 level and infant growth velocity.…”

Section: Discussionsupporting

confidence: 76%

“…Data on human milk IGF-1 levels were reported in many previous studies [12,13,14,15,16]. Milson et al [12] and Blum and Baumrucker [16] speculated that high early levels of the human milk IGF system contribute to the maturation of the infant gut.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The Study of Breast Milk IGF-1, Leptin, Ghrelin and Adiponectin Levels as Possible Reasons of High Weight Gain in Breast-Fed Infants

Kon¹,

Шилина²,

Gmoshinskaya³

et al. 2014

Ann Nutr Metab

100

View full text Add to dashboard Cite

Background: Excessive consumption of protein that leads to increased blood levels of insulin-like growth factor-1 (IGF-1) is an important risk factor for high growth velocity and obesity in formula-fed infants. However, it is not clear whether these factors can explain the high growth velocity in breast-fed infants. Aim: To study the possible links between the growth velocity in breast-fed infants and the levels of protein, IGF-1 and other hormones, which regulate energy homeostasis, in mothers' breast milk. Methods: We studied 103 mother-infant pairs. Their daily breast milk intake and level of IGF-1, leptin, ghrelin, adiponectin, protein and fat in breast milk were measured at 1, 2 and 3 months of lactation. The infant group was divided into three subgroups of low, normal and high weight gain tertiles. Results: The breast milk consumed by the infants with high weight gain contained higher levels of IGF-1 than that consumed by those with low weight gain at all periods studied (p = 0.032 at 3 months of lactation), and ghrelin levels were higher at 1 and 2 months and leptin levels at 2 and 3 months of lactation (p < 0.05). A positive correlation was observed between the breast milk IGF-1 level and infant weight gain (r = 0.294, p = 0.043). Total daily breast milk, fat and hormone intake was also higher in the high weight gain group compared to the low weight gain group. Conclusion: One of the reasons for the high growth velocity in breast-fed infants may be the enhanced levels of the studied hormones in breast milk.

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 76%

See 1 more Smart Citation

The Study of Breast Milk IGF-1, Leptin, Ghrelin and Adiponectin Levels as Possible Reasons of High Weight Gain in Breast-Fed Infants

Kon¹,

Шилина²,

Gmoshinskaya³

et al. 2014

Ann Nutr Metab

100

View full text Add to dashboard Cite

show abstract

“…However, the mechanism of action by which breastfeeding confers a protective advantage is unclear. While the macro-nutrient composition of human milk is quite stable, human milk is actually a complex mixture of bioactive factors associated with infant growth and metabolism, including insulin 6 , leptin 7, 8 , adipocyte fatty acid binding protein (AFABP) 9, 10 , several growth factors and their binding proteins 11, 12 , and ghrelin 13–15 , the composition of which varies from mother to mother and over the course of lactation.…”

Section: Introductionmentioning

confidence: 99%

Human Milk Adiponectin Affects Infant Weight Trajectory During the Second Year of Life

Woo

Guerrero²,

Guo

et al. 2012

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

Objectives Serum adiponectin (APN) is associated with lower childhood obesity, and APN concentration in human milk is associated with slower growth during active breastfeeding. Here, we examine infant weight gain in the second year of life after exposure to high or low levels of mother’s milk APN. Methods Breastfeeding mother-infant pairs were recruited in Mexico City and followed for 2 years; 192 infants with ≥12 months’ follow-up were analyzed. Monthly milk samples were assayed for APN; mothers were classified as producing high or low levels of milk APN. Infant and maternal serum APN were assessed during year 1. Infant anthropometry was measured monthly (year 1) or bi-monthly (year 2), and WHO Z-scores calculated. Longitudinal adjusted models assessed weight-for-age (WEI) and weight-for-length (WFL) Z-score trajectories from 1 to 2 years. Results Maternal serum APN modestly correlated with milk APN (r=0.37, p<0.0001) and infant serum APN (r=0.29, p=0.01). Infants exposed to high milk APN experienced increasing WEI and WFL Z-scores between age 1 and 2 years in contrast to low milk APN exposure (p for group*time=0.02 and 0.054, respectively), adjusting for growth in the first 6 months and other covariates. In contrast, infant serum APN in year 1 was not associated with rate of weight gain in year 2. Conclusions High human milk APN exposure was associated with accelerated weight trajectory during the second year of life suggesting its role in catch up growth after slower weight gain during the first year of life.

show abstract

“…Widdowson et al documented the marked increase in gastrointestinal weight, length and protein as well as DNA content of colostrum fed neonatal piglets [27]. Interestingly, EGF is resistant to degradation within gastric milieu of the preterm infant which suggests that milk born EGF may retain bioactivity in the neonatal GIT [28].Another interesting observation is the evidence of higher levels of VEGF and other growth factors in the milk of mothers who have given birth to preterm infants than in the milk of the mothers who have delivered at term [29,30]. Exposure of the neonate to the bacteria during birth and immunological factors in the breast milk, promote the maturation of the infant's gut and gut associated immune system.…”

Section: Physiology Of Gut Maturationmentioning

confidence: 72%

“Human Milk Component (HMC) Therapy”: A Novel Treatment for Gut Maturation of Preterm Infants

Manohar¹,

Tukaram²,

Satish³

et al. 2014

J Neonatal Biol

View full text Add to dashboard Cite

Even though the process of gut maturation starts right from intrauterine life, it really gets accelerated only after birth through enteral route. The preterm infants as well as infants with intrauterine growth restriction and those who had absent or reversed umbilical cord flow during their intrauterine stay are the candidates to have immature gut. They are also prone to the complications like feeding intolerance and necrotizing enterocolities.It is well established that the human milk due to the presence of growth factors and cellular components, play important role in the process of gut maturation. With this background, we have hypothesised and proposed the concept of Human Milk Component (HMC) isolation and therapy for gut maturation in preterm infants. The aqueous fraction of human milk rich in growth factors and bioactive substances and the cellular fraction rich in different kinds of cells including mesenchymal stem cells are isolated. They are given through the feeding tube to the infants with immature gut.The aqueous component of human milk acts by a passive mechanism while the cellular component acts by an active mechanism. This concept further strengthens the importance of human milk.

show abstract

Vascular endothelial growth factor, basic fibroblast growth factor, insulin-like growth factor-I and platelet-derived growth factor levels in human milk of mothers with term and preterm neonates

Cited by 28 publications

References 18 publications

The Study of Breast Milk IGF-1, Leptin, Ghrelin and Adiponectin Levels as Possible Reasons of High Weight Gain in Breast-Fed Infants

The Study of Breast Milk IGF-1, Leptin, Ghrelin and Adiponectin Levels as Possible Reasons of High Weight Gain in Breast-Fed Infants

Human Milk Adiponectin Affects Infant Weight Trajectory During the Second Year of Life

“Human Milk Component (HMC) Therapy”: A Novel Treatment for Gut Maturation of Preterm Infants

Contact Info

Product

Resources

About