Vascular Age Concept: Which Approach Is Preferable in Clinical Practice?

Rotar, O.; Alieva, A.; Бояринова, М. А.; Tolkunova, Kristina; Конради, А. О.

doi:10.18087/cardio.2019.2.10229

Cited by 15 publications

(6 citation statements)

References 14 publications

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“…The issues of vascular ageing are becoming more and more relevant, and more and more works are devoted to this issue. For example, an increase in VA, assessed using the CAVI, was previously found in patients with various cardiovascular diseases [26]; and, often VA in cardiovascular outcomes risk stratification more accurately reflects the degree of target organ remodelling in AH [27]. To date, in the available literature, we have not found works on the relationship between TGF-b1 and VA, but according to our data, a positive correlation was found between TGF-b1 and VA, which increases the significance of the TGF-b1 molecule in assessing the state of the cardiovascular system in patients with AH.…”

Section: Discussionmentioning

confidence: 86%

Transforming Growth Factor-β1, Arterial Stiffness and Vascular Age in Patients With Uncontrolled Arterial Hypertension

Подзолков

Nebieridze

Сафронова

2021

Heart, Lung and Circulation

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Lack of blood pressure control leads to a higher incidence of hypertension-mediated target organ damage (HMOD). One of the markers of HMOD is an increased arterial stiffness, an independent predictor of cardiovascular complications. However, abstract numbers showing the level of arterial stiffness do not give patients a clear understanding of the risk of their condition. In order to increase patient compliance, the term "vascular age" (VA) was introduced. Arteriosclerosis plays the main role in increasing VA. The greatest interest, according to the literature, in the study of this issue is in arteriosclerosis caused by transforming growth factor b1 (TGF-b1)-the effect of TGF-b1 on the culture of smooth muscle cells leads to their proliferation and growth; also, TGF-b1 increases the amount of collagen and accelerates the degradation of elastin. MethodsWe included 140 people in the study: 80 patients with controlled arterial hypertension (CAH), 30 with uncontrolled arterial hypertension (UAH), and 30 patients who formed the control group. All patients underwent a determination of arterial stiffness and VA using the cardio-ankle vascular index (CAVI), a corrected (blood-pressure independent) cardio-ankle vascular index (CAVI 0 ) and the concentration of TGF-b1 was measured. ResultsThe TGF-b1 value in the UAH group was 22.6 (25th percentile=20.6; 75th percentile=25.6) ng/mL, and in the control group it was 17.4 (25th percentile=11.8; 75th percentile=19.3) ng/mL. In the CAH group, an intermediate value was noted-19.2 (25th percentile=17.2; 75th percentile=24.7) ng/mL. The CAVI in the UAH group was 9.2 (25th percentile=8.5; 75th percentile=9.9), in the control group-7 (25th percentile=6.5; 75th percentile=7.5). In the CAH group, the average CAVI was 7.8 (25th percentile=7.0; 75th percen-tile=8.5). The CAVI 0 in the UAH group was 14.8 (25th percentile=12.0; 75th percentile=15.6), in the control group -9.7 (25th percentile=8.8; 75th percentile=9.7). In the CAH group, the average CAVI was 11.1 (25th percentile=10.1; 75th percentile=13.6). Vascular age in the UAH group was 71.5 (25th percentile=64; 75th percentile=74) years, in the CAH group 59 (25th percentile=49; 75th percentile=69) years, and in both groups (UAH, CAH), VA was significantly higher than the chronological age (p,0.05). In the control group, the VA did not significantly differ from the chronological age (p.0.05) and it was 54 (25th percentile=44; 75th percentile=59) years. A significant relationship was found between the TGF-b1 level and CAVI (CAH r=0.777; UAH r=0.753; p,0.05), CAVI 0 (CAH r=0.625; UAH r=0.502; p,0.05) and VA in patients with AH (CAH r=0.649; UAH r=0.753; p,0.05).

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Section: Discussionmentioning

confidence: 86%

Transforming Growth Factor-β1, Arterial Stiffness and Vascular Age in Patients With Uncontrolled Arterial Hypertension

Подзолков

Nebieridze

Сафронова

2021

Heart, Lung and Circulation

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“…The HR of patients of two groups was not significantly different (p = 0.067). The obtained indicators indicate age-related changes of vessel wall [7].…”

Section: Results Of the Researchmentioning

confidence: 96%

Functional Cardiovascular System State of Males in Yakutia Depending on Age

Guryeva¹,

Alekseeva²,

Белобородова³

et al. 2022

Proceedings of the Conference on Health and Wellbeing in Modern Society (CHW 2021)

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The purpose of the research was to assess the functional state of the cardiovascular system of men in Yakutia of 22-60 years old (depending on the age group). A morphofunctional survey included 295 men of the first mature age (21-35 years old) and 502 men of the second mature age (36-60 years old). An anthropometric survey and index assessment of the functional state of the cardiovascular system were carried out. A smaller value of body length was established at large values of body weight and BMI in men of second mature age. Overweight and obesity are significantly more commonly recorded in second mature adults. Hemodynamic indicators of second mature men were characterized by higher values of SBP, DBP, mean and pulse pressures, cardiac output. In both groups of men, patients with vagotonia predominate. An index assessment of the cardiovascular system revealed: according to the Kwaas index, 70.5 % of men of the first mature age and 62.5 % of the second mature age had a busy loafers heart; most men surveyed had high values; a low level was recorded in 49.5 % in the first group and 62.5 % in the second group by Robinson's index. A comprehensive assessment of the level of functional state and physical development by Pirogova E.A., men of the second mature age were characterized by lower indicators of the level of functional state and physical development.

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“…The calculation of VA was carried out using various approaches [24,25]. The first approach was to use instrumental markers of vascular changes (IMT, PWV, AIx) to compare patient data with age-gender reference data from the Anglo-Cardiff Collaborative Trial (ACCT) [26].…”

Section: Methodsmentioning

confidence: 99%