Transforming Growth Factor-β1, Arterial Stiffness and Vascular Age in Patients With Uncontrolled Arterial Hypertension

Подзолков, В. И.; Nebieridze, N.; Сафронова, Т. А.

doi:10.1016/j.hlc.2021.06.524

Cited by 5 publications

(4 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is not possible to say whether elevated levels of TGF-β1 are the result or the cause of cardiac hypertrophy. Other studies have shown that TGF-β1 can stimulate renin activity [30], correlated with systolic blood pressure and vascular age [31]. These correlations increase the importance of TGF-β1 in blood pressure regulation.…”

Section: Role Of Tgf-β1 In Atherosclerosismentioning

confidence: 82%

TGF-β Isoforms and GDF-15 in the Development and Progression of Atherosclerosis

Liuizė (Abramavičiūtė),

Mongirdienė

2024

IJMS

View full text Add to dashboard Cite

The effect of oxidised lipoproteins on the endothelium, monocytes, platelets, and macrophages is a key factor in the initiation and development of atherosclerosis. Antioxidant action, lipoprotein metabolism, and chronic inflammation are the fields of research interest for better understanding the development of the disease. All the fields are related to inflammation and hence to the secretion of cytokines, which are being investigated as potential diagnostic markers for the onset of atherosclerosis. Pathways of vascular damage are crucial for the development of new laboratory readouts. The very early detection of endothelial cell damage associated with the onset of atherosclerosis, allowing the initiation of therapy, remains a major research goal. This article summarises the latest results on the relationship of tumour growth factor beta (TGF-β) isoforms and growth differentiation factor 15 (GDF-15) to the pathogenesis of atherosclerosis: which cells involved in atherosclerosis produce them, which effectors stimulate their synthesis and secretion, how they influence atherosclerosis development, and the relationship between the levels of TGF-β and GDF-15 in the blood and the development and extent of atherosclerosis.

show abstract

Section: Role Of Tgf-β1 In Atherosclerosismentioning

confidence: 82%

TGF-β Isoforms and GDF-15 in the Development and Progression of Atherosclerosis

Liuizė (Abramavičiūtė),

Mongirdienė

2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Arterial stiffness is becoming increasingly important in clinical applications as an early marker of hypertension-mediated target organ damage [ 2 ]. Some studies have reported that CAVI is high in hypertensive patients, especially in those with uncontrolled hypertension [ 12 ]. However, the magnitude of the relationship between arterial stiffness and MUCH is poorly reported.…”

Section: Discussionmentioning

confidence: 99%

“…It is infuenced by chronic exposure of the arterial wall to increased BP but is essentially independent of BP at the time of measurement. Some studies have reported that CAVI is high in hypertensive patients, especially in those with uncontrolled hypertension [12][13][14]. However, the relationship between MUCH and CAVI is largely unclear.…”

Section: Introductionmentioning

confidence: 99%

Association between Cardio-Ankle Vascular Index and Masked Uncontrolled Hypertension in Hypertensive Patients: A Cross-Sectional Study

Wang

Guo

et al. 2022

Journal of Healthcare Engineering

View full text Add to dashboard Cite

Detection of masked uncontrolled hypertension (MUCH) that was defined for treated hypertensive individuals who had normal office blood pressure (BP) but elevated ambulatory BP remains largely challenging. Arterial stiffness is one of the leading risk markers for hypertension and can be clinically assessed by the cardio-ankle vascular index (CAVI). This study aimed to evaluate the association between CAVI and MUCH. A total of 155 hypertensive patients were included with their office BP levels and ambulatory BP monitoring measurements, which were divided into controlled hypertension (CH), MUCH, and sustained uncontrolled hypertension (SUCH) groups, respectively. There were 48 patients with CH, 56 patients with MUCH, and 51 patients with SUCH. Both MUCH and SUCH groups had a significantly higher CAVI than the CH group (9.05 (8.20–9.91) vs. 8.33 (7.75–9.15), p = 0.017 , and 9.75 (8.35–10.50) vs. 8.33 (7.75–9.15), p = 0.002 , respectively). There was no significant difference in CAVI values between the MUCH and SUCH groups. Multinomial logistic regression analysis exhibited that compared with the CH group, increased CAVI levels were positively associated with the presence of MUCH and SUCH (OR 2.046, 95% CI (1.239–3.381), p = 0.005 ; OR 2.215, 95% CI (1.310–3.747), p = 0.003 ) after adjusting for confounders. However, there was a similar trend of the CAVI in the MUCH and SUCH groups (OR 0.924, 95% CI (0.629–1.356), p = 0.686 ). In summary, our findings support, for the first time, the novel notion that CAVI as an arterial stiffness parameter is an independent risk factor for MUCH, being equally important to MUCH and SUCH. When the assessed CAVI is high in hypertensive patients with normotensive office BP levels, it is necessary to further investigate with a 24 h ambulatory BP monitoring to estimate the longstanding BP control. CAVI may be used as a noninvasive indicator to identify patients with MUCH earlier.

show abstract

“…Another study found that transforming growth factor β1 (TGF-β1) has a key role in cardiovascular disease. Indeed, Podzolkov et al, reported an increased concentration of TGF-β1 in patients with uncontrolled arterial hypertension and further demonstrated a positive association with arterial stiffness [ 43 ]. Rho/Rho-associated coiled-coil containing kinases 1 and 2 (ROCK1 and ROCK2) modulates TGF-β1 and regulates cellular contraction and vascular remodeling.…”

Section: Clinical Risk Factor For Arterial Stiffnessmentioning

confidence: 99%

Aging of the Arterial System

Castelli

Gidaro

Casu

et al. 2023

IJMS

View full text Add to dashboard Cite

Aging of the vascular system is associated with deep changes of the structural proprieties of the arterial wall. Arterial hypertension, diabetes mellitus, and chronic kidney disease are the major determinants for the loss of elasticity and reduced compliance of vascular wall. Arterial stiffness is a key parameter for assessing the elasticity of the arterial wall and can be easily evaluated with non-invasive methods, such as pulse wave velocity. Early assessment of vessel stiffness is critical because its alteration can precede clinical manifestation of cardiovascular disease. Although there is no specific pharmacological target for arterial stiffness, the treatment of its risk factors helps to improve the elasticity of the arterial wall.

show abstract

Transforming Growth Factor-β1, Arterial Stiffness and Vascular Age in Patients With Uncontrolled Arterial Hypertension

Cited by 5 publications

References 27 publications

TGF-β Isoforms and GDF-15 in the Development and Progression of Atherosclerosis

TGF-β Isoforms and GDF-15 in the Development and Progression of Atherosclerosis

Association between Cardio-Ankle Vascular Index and Masked Uncontrolled Hypertension in Hypertensive Patients: A Cross-Sectional Study

Aging of the Arterial System

Contact Info

Product

Resources

About