$$\varvec{Q}ET$$ Q E T : a QoS-based energy-aware task scheduling method in cloud environment

Genome-Wide Profiling of Epstein-Barr Virus (EBV) Isolated from EBV-Related Malignancies

“…The EBV integration rates were 25.6% (10/39), 16.0% (4/25), 9.6% (17/177) in the EBVaGC, NKTCL, and NPC tumors, respectively, which were lower than HPV integration in cervical cancer (76.3%) and head and neck squamous cell carcinoma (60.7%), and HBV in hepatocellular carcinoma (92.6%) [54,[57][58][59]. They found that EBV integrations into the introns could decrease the expression of the inflammationrelated genes, TNFAIP3, PARK2, and CDK15, in NPC tumors [27]. The EBV integration breakpoints were frequently at oriP or terminal repeats, and were surrounded by microhomology sequences, consistent with a mechanism for integration involving viral genome replication and microhomology-mediated recombination, which has an important role in the integration of other tumorigenic viruses, HBV and HPV [54,59].…”

“…Comprehensive analyses of WGS datasets may reveal some novel findings on EBV integration. Recently, a comprehensive survey of EBV integration in a variety of human malignancies, including NPC, EBVaGC, and NKTCL was conducted, using EBV genome capture combined with ultra-deep sequencing, which could efficiently detect integrated EBV sequences from background "noise" introduced by nuclear EBV episomes [27]. The EBV integration rates were 25.6% (10/39), 16.0% (4/25), 9.6% (17/177) in the EBVaGC, NKTCL, and NPC tumors, respectively, which were lower than HPV integration in cervical cancer (76.3%) and head and neck squamous cell carcinoma (60.7%), and HBV in hepatocellular carcinoma (92.6%) [54,[57][58][59].…”

“…In addition, authors only selected some potential breakpoints to perform PCR and Sanger sequencing for validating. For example, Xu et al randomly select 12 integrations from 197 breakpoints identified from NPC and other EBVassociated malignancies, and only 10 breakpoints were successfully validated [27]. As integration of EBV sequence into the host genome and the consequent disruption of the important host genes might represent a novel tumorigenesis mechanism in EBV associated malignancies, all the potential EBV integration breakpoints should be validated and biological function of host genes involved should be further conducted.…”

“…The number of available EBV sequences is increasing exponentially and up to now, more than 500 EBV genomes have been sequenced from a variety of human malignancies, including NPC, lymphoma, gastric cancer, and lung cancer, as well as from healthy carriers [14][15][16][17][18][19][20][21][22][23][24][25]. Progress has made it possible that the population-based case-control studies of EBV strain variation in EBV-related cancer patients as compared with the healthy population and a comprehensive survey of EBV integration in a variety of human malignancies can be effectively conducted [20,[25][26][27]. These developments have revealed that various EBV strains are differentially distributed throughout the world, and that the behavior of cancer-derived EBV strains is different from that of the prototype EBV strain of noncancerous origin.…”

An IoT-Oriented Offloading Method with Privacy Preservation for Cloudlet-Enabled Wireless Metropolitan Area Networks

“…On the other hand, the energy consumption and the transmission time are the important parts to evaluate the quality of IoT-oriented offload methods [ 25 , 26 ]. If the IoT data is encrypted, it will cost much more time in data processing and transmission, since the size of the data is greater.…”