Genome-Wide Profiling of Epstein-Barr Virus (EBV) Isolated from EBV-Related Malignancies

Liu, Ying; Lu, Zheming; Huang, Hongying

doi:10.5772/intechopen.93244

Cited by 2 publications

(2 citation statements)

References 59 publications

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“…The investigation of EBV genome sequences is important due to their association with several human malignancies ( 165 ). Prior to 2013, GenBank had whole genome sequences from less than 10 strains of EBV ( 393 ). Conventional sequencing techniques were inefficient, expensive and could help investigate only a few viral genes at a time.…”

Section: High-throughput Approaches To Study Ebv-associated Cancersmentioning

confidence: 99%

EBV-associated diseases: Current therapeutics and emerging technologies

Chakravorty

Afzali²,

Kazemian³

2022

Front. Immunol.

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EBV is a prevalent virus, infecting >90% of the world’s population. This is an oncogenic virus that causes ~200,000 cancer-related deaths annually. It is, in addition, a significant contributor to the burden of autoimmune diseases. Thus, EBV represents a significant public health burden. Upon infection, EBV remains dormant in host cells for long periods of time. However, the presence or episodic reactivation of the virus increases the risk of transforming healthy cells to malignant cells that routinely escape host immune surveillance or of producing pathogenic autoantibodies. Cancers caused by EBV display distinct molecular behaviors compared to those of the same tissue type that are not caused by EBV, presenting opportunities for targeted treatments. Despite some encouraging results from exploration of vaccines, antiviral agents and immune- and cell-based treatments, the efficacy and safety of most therapeutics remain unclear. Here, we provide an up-to-date review focusing on underlying immune and environmental mechanisms, current therapeutics and vaccines, animal models and emerging technologies to study EBV-associated diseases that may help provide insights for the development of novel effective treatments.

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Section: High-throughput Approaches To Study Ebv-associated Cancersmentioning

confidence: 99%

EBV-associated diseases: Current therapeutics and emerging technologies

Chakravorty

Afzali²,

Kazemian³

2022

Front. Immunol.

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“…Furthermore, other diseases related to this virus include Hodgkin's lymphoma, Burkitt lymphoma (BL), post-transplant lymphoproliferative disorders (PTLD), nasopharyngeal carcinoma (NPC), and gastric cancer [96]. EBV has a double-stranded DNA genome around 172 kb long and encodes more than 85 genes [97].…”

Section: Epstein-barr Virus (Ebv)mentioning

confidence: 99%

Small extracellular vesicles as key players in cancer development caused by human oncogenic viruses

Mahmoudvand

Shokri

Nakhaie

et al. 2022

Infect Agents Cancer

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Background Exosomes are the smallest group of extracellular vesicles in size from 30 to 150 nm, surrounded by a lipid bilayer membrane, and originate from multivesicular bodies secreted by different types of cells, such as virus-infected cells. The critical role of exosomes is information transfer among cells, representing a unique way for intercellular communication via a load of many kinds of molecules, including various signaling proteins and nucleic acids. In this review, we aimed to comprehensively investigate the role of exosomes in promoting human oncogenic viruses-associated cancers. Methods Our search was conducted for published researches between 2000 and 2022 by using several international databases includeing Scopus, PubMed, and Web of Science as well as Google scholar. We also reviewed additional evidence from relevant published articles. Results It has been shown that exosomes can create the conditions for viral spread in viral infections. Exosome secretion in a human tumor virus can switch on the cell signaling pathways by transferring exosome-encapsulated molecules, including viral oncoproteins, signal transduction molecules, and virus-encoded miRNAs, into various cells. Conclusion Given the role of exosomes in viruses-associated cancers, they can also be considered as molecular targets in diagnosis and treatment.

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Genome-Wide Profiling of Epstein-Barr Virus (EBV) Isolated from EBV-Related Malignancies

Cited by 2 publications

References 59 publications

EBV-associated diseases: Current therapeutics and emerging technologies

EBV-associated diseases: Current therapeutics and emerging technologies

Small extracellular vesicles as key players in cancer development caused by human oncogenic viruses

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