Variations in levels of IL-6 and TNF-α in type 2 diabetes mellitus between rural and urban Ashanti Region of Ghana

Darko, Samuel Nkansah; Yar, Denis Dekugmen; Owusu‐Dabo, Ellis; Awuah, Anthony Afum-Adjei; Dapaah, Williams; Addofoh, Nicholas; Salifu, Samson Pandam; Awua-Boateng, Nana Yaa; Adomako‐Boateng, Fred

doi:10.1186/s12902-015-0047-9

Cited by 21 publications

(13 citation statements)

References 30 publications

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“…In the present study, levels of proinflammatory cytokines such as TNF‐alpha, IL‐6 and anti‐inflammatory cytokine IL‐10 were significantly higher in T2DM individuals compared to controls. Similar results have been reported in T2DM patients from other countries 17‐21 . However, some study reported that there was no significant difference in TNF‐alpha, 22 IL‐6, 23 and IL‐10 24 between T2DM and controls.…”

Section: Discussionsupporting

confidence: 84%

Oxidative stress and inflammatory markers in type 2 diabetic patients

Malik

Morya

Saha

et al. 2020

Eur J Clin Investigation

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Background: Type 2 diabetes mellitus (T2DM) is most demanding public health problem of 21st century. Uncontrolled diabetes may cause complications affecting any part of gut from mouth to rectum presenting as vomiting, nausea, bloating, abdominal pain, constipation and diarrhoea. The aim of this study was to compare levels of oxidative stress and inflammatory markers in small intestinal bacterial overgrowth (SIBO)-positive and negative diabetic patients. Subjects and methods: An observational analytical study was conducted on 300 T2DM (>5 years' duration) attending Diabetic Clinic. A total of 200 age-and sexmatched healthy individuals were enrolled as controls. Noninvasive glucose hydrogen breath test was used to diagnose SIBO. A total of 5 mL blood was taken. Plasma was used for measurement of inflammatory cytokines (TNF-α, IL-6 and IL-10) by ELISA. Hemolysate was used for measurement of lipid peroxidation, reduced GSH, superoxide dismutase and catalase. Results: It was observed that constipation was present in 59.6% T2DM patients.SIBO was observed significantly higher (P < .0001) in T2DM patients than controls.Inflammatory and oxidative stress markers were significantly (P < .001) higher in diabetic and SIBO-positive patients than controls and SIBO negative. Reduced GSH was significantly (P < .05) lower whereas superoxide dismutase (SOD) and catalase antioxidant enzymes were significantly (<.05) higher in diabetic and SIBO-positive patients than controls and SIBO-negative patients. Conclusion: From this study, it could be concluded that SIBO in T2DM patients can cause oxidative stress and inflammation. Therefore, SIBO should be taken care to prevent further damage to intestine. K E Y W O R D Sinflammatory markers, orocecal transit time, oxidative stress, small intestinal bacterial over growth, type 2 diabetes mellitus 2 of 6 | MALIK et AL.

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Section: Discussionsupporting

confidence: 84%

Oxidative stress and inflammatory markers in type 2 diabetic patients

Malik

Morya

Saha

et al. 2020

Eur J Clin Investigation

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“…In addition, CRP is a biomarker for patients with DM (25). Furthermore, a previous study revealed that IL-6 levels are higher in patients with type 2 DM compared with healthy individuals (26). In the present study, it was observed that Tan-IIA treatment significantly decreased inflammatory factors TNF-α, IL-6, CRP and Il-8 in a type 2 DM rat model.…”

Section: Discussionsupporting

confidence: 70%

Tanshinone IIA improves diabetes mellitus via the NF‑κB‑induced AMPK signal pathway

Yuan

Zhang

et al. 2018

Exp Ther Med

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Diabetes mellitus (DM) is a systemic metabolic disease. Tanshinone IIA (Tan-IIA) presents potential benefits for DM. The purpose of this study was to investigate the efficacy of Tan-IIA in type 2 DM rats and explore its potential mechanism in renal cells. A type 2 DM rat model was established and administered with Tan-IIA or PBS. It was demonstrated that Tan-IIA treatment significantly reduced levels of total cholesterol, non-esterified fatty acids, total triglyceride and low-density lipoprotein cholesterol in experimental DM rats compared with the control group. The results indicated that Tan-IIA treatment significantly decreased levels of interleukin (IL)-8, tumor necrosis factor-α, C-reactive protein and IL-6. It was identified that Tan-IIA treatment significantly decreased nuclear factor-κB levels and significantly elevated 5' adenosine monophosphate-activated protein kinase levels. Western blot analysis indicated that Tan-IIA elevated immunocyte precipitation in renal cells. Furthermore, Tan-IIA treatment improved lipid metabolism, glucose metabolism, insulin resistance and body weight of type 2 DM rats. In conclusion, Tan-IIA administration may inhibit inflammatory cytokines and alleviate type 2 DM symptoms in experimental rats.

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“…In the present study, TNF-α and IL-6 were significantly higher in Met S ( P <0.05) as compared with the controls and the two cytokines significantly correlated with HOMA- IR and each other. These results were supported by the earlier studies conducted on Ghanian and Iranian population reporting increased levels of TNF-α and IL-6 in T2DM and Met S; it was observed that cytokines acting in autocrine and paracrine fashion create a hostile environment of metabolic inflammation and insulin resistance [26,27]. IL-6 is a secondary cytokine released in response to the primary cytokine TNF-α; IL-6 induces hepatocytes to release CRP that highly correlates with atherosclerotic plaques, modulates innate immunity and contributes to IR [3,7,13].…”

Section: Discussionsupporting

confidence: 81%

Serum profile of cytokines and their genetic variants in metabolic syndrome and healthy subjects: a comparative study

et al. 2019

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Aim: To identify genetic variants in promoter areas of IL-6 -174 G>C and TNF-α -308 G>A in metabolic syndrome (Met S) and controls and associate them with Met S and serum cytokine levels.It was a cross-sectional study, including 224 cases of Met S and 200 controls. A fasting blood sample was taken and biochemical parameters including serum glucose, insulin, lipid profile, interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) were measured. Restriction fragment length polymorphism was used to identify the genetic variants of IL-6 and TNF-α. Serum levels of IL-6 and TNF-α and insulin resistance were significantly higher in cases than the controls. IL-6 showed significant positive correlation with HOMA-IR and TNF-α. CC genotype of IL-6 was associated with the increased risk of Met S (P=0.016, OR for CC vs GC+GG = 2.33, CI: 1.15–4.71). There was no significant difference of TNF-α genotypes between the cases and the controls. Serum TNF-α and IL-6 levels were significantly higher in AA and CC genotypes of TNF-α (-308 G>A) and IL-6 (-174 G>C) as compared with the GG (P=0.00 and P=0.001). Significant correlation of IL-6 with TNF-α and insulin resistance was observed that may provide us a therapeutic target for preventing metabolic derangements from insulin resistance.

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Variations in levels of IL-6 and TNF-α in type 2 diabetes mellitus between rural and urban Ashanti Region of Ghana

Cited by 21 publications

References 30 publications

Oxidative stress and inflammatory markers in type 2 diabetic patients

Oxidative stress and inflammatory markers in type 2 diabetic patients

Tanshinone IIA improves diabetes mellitus via the NF‑κB‑induced AMPK signal pathway

Serum profile of cytokines and their genetic variants in metabolic syndrome and healthy subjects: a comparative study

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