Serum profile of cytokines and their genetic variants in metabolic syndrome and healthy subjects: a comparative study

Zafar, Uzma; Khaliq, Saba; Ahmad, Hafiz Usman; Lone, Khalid P.

doi:10.1042/bsr20181202

Cited by 22 publications

(13 citation statements)

References 37 publications

(44 reference statements)

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“…( 27 ) showed that in patients with high TG levels, their plasma IL-6 levels were increased, and this was accompanied by a rise in other inflammation-related biochemical markers and the activation of endothelial cells. Similarly, another cross-sectional study also found that MS patients with hypertriglyceridemia had a significant increase in plasma IL-6 levels, and that IL-6 was positively correlated with HOMA-IR ( 28 ). We also found that the ΔTG level was positively correlated with the ΔFFA level in the high-TG group.…”

Section: Discussionmentioning

confidence: 91%

Lower Baseline Serum Triglyceride Levels Are Associated With Higher Decrease in Body Mass Index After Laparoscopy Sleeve Gastrectomy Among Obese Patients

Huang

et al. 2021

Front. Endocrinol.

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AimsTo investigate the predictive value of baseline serum triglyceride (TG) levels for improvements of metabolism after laparoscopic sleeve gastrectomy (LSG).Methods112 obese patients [body mass index (BMI) ≥ 35 kg/m2] underwent LSG and with complete information of anthropometric and metabolic parameters were divided into normal TG group (group A) and high TG group (group B), while group A had TG levels ≤ 1.7 mmol/L, and group B had TG levels > 1.7 mmol/L. The post-operative changes (Δ) in metabolic parameters between the two groups were compared.ResultsIn the whole cohort, the metabolic parameters were significantly improved at 6 months after LSG. BMI and waist circumference (WC) decreased significantly in the two groups. The ΔBMI among group A and group B were 11.42±3.23 vs 9.13±2.77 kg/m2 (p<0.001), respectively. ΔBMI was positively correlated with ΔWC (r=0.696, p<0.001), Δfasting insulin level (r=0.440, p=0.002), Δfasting serum C peptide level (r=0.453, p=0.002), and Δhomeostasis model assessment insulin resistance index (r=0.418, p=0.004) in group A. Compared with group B, group A had a significantly higher odds ratio (OR) of 2.83 (95% confidence interval [CI]1.25–6.38, p=0.012)and 2.73 (95% CI 1.11–6.72, p=0.029) for ΔBMI and ΔWC after adjustment for age and gender, respectively.ConclusionsObese patients with baseline TG levels under 1.7 mmol/L had greater loss of weight at six months follow-up later LSG. This finding suggests that baseline TG level may have a predictive value for weight loss, at least in the short-term follow-up.

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Section: Discussionmentioning

confidence: 91%

Lower Baseline Serum Triglyceride Levels Are Associated With Higher Decrease in Body Mass Index After Laparoscopy Sleeve Gastrectomy Among Obese Patients

Huang

et al. 2021

Front. Endocrinol.

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“…A reduction of −0.46 mg/L constitutes a ~15% change in comparison with the 3 mg/L cut-off level but only a ~5% change as compared with the average top normal value of 10.0 mg/L. Similarly, the normal circulating levels of TNF-α, another important inflammatory biomarker, exhibit a very high variability which expand from non-detectable up to 76 pg/mL, though, most values seem to be placed between 0.0 and 16 pg/mL [72][73][74][78][79][80][81][82][83][84][85][86][87][88]. A potential reduction in TNF-α of −3.0 pg/mL in response to the (poly)phenols intake constitute a ~20% change in comparison with a top normal level of 16 pg/mL but only a ~4% change in comparison with a maximum normal value of 76 pg/mL.…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review of the Cardiometabolic Benefits of Plant Products Containing Mixed Phenolics and Polyphenols in Postmenopausal Women: Insufficient Evidence for Recommendations to This Specific Population

et al. 2021

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Menopause is characterized by endocrine and physiological changes and is often accompanied by increased body weight and cholesterol, glucose intolerance, and/or hypertension. These alterations are associated with increased risk for cardiovascular diseases (CVDs) and Type II diabetes mellitus (T2DM) that may be moderate by dietary plant phenolic compounds. In this review, we examine the current evidence of the impact of a variety of plant products (foods, extracts, beverages) rich in a mixture of phenolics and polyphenols on: (i) glucose and insulin levels; (ii) lipid profile; (iii) blood pressure; and (iv) biomarkers of inflammation and oxidative stress in postmenopausal women. We critically evaluate both the results of a range of intervention studies conducted in this specific subpopulation and the level of evidence supporting the benefits of consuming those products after the menopause. Overall, the current available evidence does not allow for specific dietary recommendations of these plant products rich in phenolics and polyphenols in this high-risk subpopulation. Our data show rather variable and small effects of the different products examined on the cardiometabolic biomarkers and further support the need to: (1) improve the quality of the study designs and data reporting; and (2) understand the variability in the response of the different biomarkers and establish clear differences between healthy and cardiometabolic disease levels.

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“…TNF-α is a proinflammatory cytokine secreted from the perivisceral fat, and its role is linked to insulin resistance, atherosclerosis, and endothelial dysfunction. 2,9 The role of inflammatory markers like TNF-α has not been widely documented in MetS, although its activity in MetS components is being described. Various studies have demonstrated that pro-inflammatory markers Serum TNF-α levels in metabolic syndrome like TNF-α impart their roles in developing cardiovascular diseases, metabolic syndrome, obesity, type 2 diabetes, insulin resistance, and non-alcoholic fatty liver disease.…”

Section: Discussionmentioning

confidence: 99%

“…Various characteristics contribute to this ailment, including the development of the cardiovascular disease, hypertension, impaired glucose tolerance, type 2 diabetes mellitus (T2DM), or impaired fasting hyperglycemia), insulin resistance, central obesity, and impaired lipid levels. 1 , 2 These features may occur individually by chance, but they can raise cardiac risk in combination. 3 As the metabolic syndrome is a complex anomaly, the definition for disease categorization has been explained by various organizations like Adult Treatment Panel III (ATP III), National Cholesterol Education Program (NCEP), the World Health Organization (WHO), and International Diabetes Foundation (IDF)and.…”

Section: Introductionmentioning

confidence: 99%

Determination of serum tumor necrosis factor-alpha (TNF-α) levels in metabolic syndrome patients from Saudi population

et al. 2021

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Objectives: To detect the relationship between serum tumor necrosis factor-alpha (TNF-α) and metabolic syndrome (MetS) components in patients of the Saudi population. Methods: This cross-sectional study was carried out at Jouf University Saudi Arabia from September 2019 to August 2020 and comprised of 183 individuals (91 cases and 92 controls). The blood samples were drawn from the patients visiting two tertiary care settings of Al Jouf province. Biochemical analysis was conducted on various instruments, and serum TNF-α was measured by the ELISA method. Results: The levels of serum glucose fasting, lipid profile, HbA1c and body mass index (BMI) were raised significantly in cases of MetS than controls (p = 0.001). Serum TNF-α was significantly higher in patients (58.04 ± 15.44) than controls (48.81 ± 10.30). It was correlated with the BMI, blood HbA1c, serum fasting glucose (SFG) and serum high density lipoprotein (HDL). The weak positive correlation was found with BMI (r = 0.18; p = 0.01), serum glucose (r = 0.21; p = 0.007) and HbA1c (r = 0.14; p = 0.04), but found negative association with serum HDL (r = -0.18; p = 0.01). Conclusion: The serum TNF-α was raised in metabolic syndrome patients than the healthy controls. It was positively associated with high BMI, serum fasting glucose, and HbA1c and found linked and negatively linked to low HDL levels in MetS patients in the Saudi population. doi: https://doi.org/10.12669/pjms.37.3.3897 How to cite this:Ullah MI, Alzahrani B, Alsrhani A, Atif M, Alameen AAM, Ejaz H. Determination of serum tumor necrosis factor-alpha (TNF-α) levels in metabolic syndrome patients from Saudi population. Pak J Med Sci. 2021;37(3):---------. doi: https://doi.org/10.12669/pjms.37.3.3897 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Serum profile of cytokines and their genetic variants in metabolic syndrome and healthy subjects: a comparative study

Cited by 22 publications

References 37 publications

Lower Baseline Serum Triglyceride Levels Are Associated With Higher Decrease in Body Mass Index After Laparoscopy Sleeve Gastrectomy Among Obese Patients

Lower Baseline Serum Triglyceride Levels Are Associated With Higher Decrease in Body Mass Index After Laparoscopy Sleeve Gastrectomy Among Obese Patients

A Systematic Review of the Cardiometabolic Benefits of Plant Products Containing Mixed Phenolics and Polyphenols in Postmenopausal Women: Insufficient Evidence for Recommendations to This Specific Population

Determination of serum tumor necrosis factor-alpha (TNF-α) levels in metabolic syndrome patients from Saudi population

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