1982
DOI: 10.1016/0021-9975(82)90002-0
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Variation in the thermal stability of isolates of foot-and-mouth disease type SAT 2 and its significance in the selection of vaccine strains

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1983
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Cited by 7 publications
(6 citation statements)
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“…Formulated vaccines from inactivated wild-type and stabilised O and SAT2 viruses, produced equivalent protective levels of neutralising antibodies in cattle, demonstrating the immunogenicity of the engineered particles. The stabilised inactivated vaccine antigen is also intact after 96 hours at 37°C and will be more tolerant of less than optimal cold chain performance; goals for the stability of SAT2 are given by Anderson et al37. Furthermore, after storage for one or six months at 4°C, stabilised particles produced substantially higher VNT in guinea pigs than wild-type, commensurate with an increase in vaccine shelf-life.…”
Section: Discussionmentioning
confidence: 99%
“…Formulated vaccines from inactivated wild-type and stabilised O and SAT2 viruses, produced equivalent protective levels of neutralising antibodies in cattle, demonstrating the immunogenicity of the engineered particles. The stabilised inactivated vaccine antigen is also intact after 96 hours at 37°C and will be more tolerant of less than optimal cold chain performance; goals for the stability of SAT2 are given by Anderson et al37. Furthermore, after storage for one or six months at 4°C, stabilised particles produced substantially higher VNT in guinea pigs than wild-type, commensurate with an increase in vaccine shelf-life.…”
Section: Discussionmentioning
confidence: 99%
“…Thermostability of vaccine antigen is crucial for the generation of immune responses in animals to achieve protection against FMDV [37], [38], [39]. The thermal stability of the 146S particles from the seven serotypes at 49°C differ considerably [40], while differences exist within serotype SAT2 at 37°C [41]. A contributory factor for better protection in A Malaysia vaccinated cattle may therefore be the relative instability of the SAT vaccine antigen in vivo compared with A serotype vaccine antigen [15].…”
Section: Discussionmentioning
confidence: 99%
“…A contributory factor for better protection in A Malaysia vaccinated cattle may therefore be the relative instability of the SAT vaccine antigen in vivo compared with A serotype vaccine antigen [15]. It has also been reported that the SAT serotype vaccines, particularly the SAT2 serotype, are less immunogenic than serotypes O, A and C [41]. The CMI responses detected by many of the assays (whole blood IFN-γ assay and Lymphocyte proliferation assay) were higher for the A Malaysia 97 vaccinated animals compared to the SAT2 Eritrea animals and this might be a factor in the more consistent protection afforded by the A Malaysia 97 vaccine in all groups.…”
Section: Discussionmentioning
confidence: 99%
“…To control localized divergent strains, such as K65/82, it is suggested that immediate revaccination with K183/74 vaccine and/or supplementation of vaccines with Tan 5/68 would be appropriate. Confirmation of this is given by the demonstration that a SAT 2 K183/74 vaccine inoculated twice into susceptible cattle at Pirbright (UK) and Embakasi (Kenya) protected cattle fully against challenge with K65/82 virus and, in contrast to the report by Anderson et al (1982), a high neutralizing Fig. 1.…”
Section: Discussionmentioning
confidence: 82%
“…However, since low antibody titres were observed even in animals which were immune to challenge with virulent virus, it was difficult to monitor the efficacy of these vaccines under field conditions. During 1980-2 an apparently thermostable virus, strain R1215 (Anderson, Doughty & Spooner, 1982), was adopted as the vaccine virus. This strain had been derived from the oropharynx of a symptomless carrier animal.…”
Section: Introductionmentioning
confidence: 99%