Variation in human genetic polymorphisms, their association with <i>Helicobacter pylori</i> acquisition and gastric cancer in a multi‐ethnic country

Schmidt, H; Ha, D. M.; Taylor, E F; Kovách, Zsuzsanna; Goh, Khean‐Lee; Fock, Kwong Ming; Barrett, Jennifer; Forman, David; Mitchell, Hazel M.

doi:10.1111/j.1440-1746.2011.06799.x

Cited by 29 publications

(21 citation statements)

References 29 publications

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“…Asians are markedly higher compared with those in aCaucasians or African-Americans (53)(54)(55). Similar cases were observed in several other polymorphisms (56). It is hypothesized that various living environments and diverse genotypes lead to different degrees of cancer susceptibility (8).…”

Section: No (Cases/controls) Of Cyp2e1 Rsal/pstl Polymorphism ------supporting

confidence: 52%

Association between CYP2E1 polymorphisms and risk of gastric cancer: An updated meta-analysis of 32 case-control studies

Zhang

Wang

et al. 2016

Molecular and Clinical Oncology

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Abstract. Previous studies suggested that RsaI/PstI and DraI polymorphisms on cytochrome P450 2E1 (CYP2E1) may be associated with susceptibility to gastric cancer (GC). However, this association remains ambiguous. A meta-analysis of previously published studies was performed in an attempt to elucidate this association. The odds ratio and 95% confidence interval were used to assess the strength of the association. In the overall analyses of RsaI/PstI and DraI, no association was identified. In the subgroup analyses, RsaI/PstI was identified to increase the risk of GC in the smoking population. In addition, in the previous studies of interactions with other genes, RsaI/PstI was revealed to be associated with increased GC risks when glutathione S-transferase-µ-1 or glutathione S-transferase θ-1 was null or DraI was homozygous wild-type. However, these stratified analyses were lacking credibility due to the limitation of correlational study numbers. In conclusion, CYP2E1 polymorphisms revealed no association with the risk of GC.

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Section: No (Cases/controls) Of Cyp2e1 Rsal/pstl Polymorphism ------supporting

confidence: 52%

Association between CYP2E1 polymorphisms and risk of gastric cancer: An updated meta-analysis of 32 case-control studies

Zhang

Wang

et al. 2016

Molecular and Clinical Oncology

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“…In addition to ELISA, serum samples from GC patients shown to be H. pylori negative by ELISA were investigated further by Immunoblot (MPD Helico Blot 2.1, MP Biomedicals, Australia) according to the manufacturer's instructions. These results have been published in part elsewhere [38].…”

Section: Methodsmentioning

confidence: 55%

“…Data on TLR4 Asp299Gly and Thr399Ile in our ethnic Chinese case-control study has been published previously [38], therefore the results of that study were included in our meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

The Role of TLR2, TLR4 and CD14 Genetic Polymorphisms in Gastric Carcinogenesis: A Case-Control Study and Meta-Analysis

et al. 2013

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Background: In addition to Helicobacter pylori infection, host genetic factors contribute to gastric cancer (GC). Recognition of H. pylori is known to involve Toll-like receptors (TLR), which subsequently leads to activation of NF-kB. Thus, the overall aim of this study was to estimate for the first time the pooled effect size of polymorphisms in TLR2, TLR4 and CD14 on GC development through a meta-analysis.

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“…Ethnic variations in various genes among different ethnicities may influence gastric cancer susceptibility [50], [51]. CYP2E1 variations differ among various ethnicities [52].…”

Section: Discussionmentioning

confidence: 99%

CYP2E1 RsaI/PstI Polymorphism and Gastric Cancer Susceptibility: Meta-Analyses Based on 24 Case-Control Studies

Zhang

Wang

et al. 2012

PLoS ONE

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BackgroundPrevious reports implicate CYP2E1 RsaI/PstI polymorphism as a possible risk factor for several cancers. Published studies on the relationship of CYP2E1 RsaI/PstI polymorphisms with the susceptibility to gastric cancer are controversial. This study aimed to determine this relationship accurately.MethodsMeta-analyses that assessed the association of CYP2E1 RsaI/PstI variations with gastric cancer were conducted. Subgroup analyses on ethnicity, smoking status, alcohol consumption, and source of controls were also performed. Eligible studies up to Mar 2012 were identified.ResultsAfter rigorous searching and screening, 24 case-control studies comprising 3022 cases and 4635 controls were selected for analysis. The overall data failed to indicate the significant associations of CYP2E1 RsaI/PstI polymorphisms with the gastric cancer risk [c2 vs. c1: odds ratio (OR) = 1.06; 95% confidence interval (CI) = 0.88–1.28; c2c2 vs. c1c1: OR = 1.23; 95% CI = 0.78–1.92; c2c2+c1c2 vs. c1c1: OR = 0.93; 95% CI = 0.79–1.10]. Similar results were observed in the subgroup analyses on ethnicity, drinking status, and source of controls. However, in the subgroup analysis on smoking status, a borderline increase in cancer risk was found among long-term smokers (c2c2+c1c2 vs. c1c1: OR = 1.39; 95% CI = 1.00–1.92).ConclusionCYP2E1 RsaI/PstI polymorphisms may modify the susceptibility to gastric cancer among individuals who have a smoking history. Large and well-designed studies are needed to confirm this conclusion.

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Variation in human genetic polymorphisms, their association with Helicobacter pylori acquisition and gastric cancer in a multi‐ethnic country

Abstract: These findings contribute to the understanding of the genetic variation between ethnicities, which may influence H. pylori susceptibility and the outcome of infection.

Cited by 29 publications

References 29 publications

Association between CYP2E1 polymorphisms and risk of gastric cancer: An updated meta-analysis of 32 case-control studies

Association between CYP2E1 polymorphisms and risk of gastric cancer: An updated meta-analysis of 32 case-control studies

The Role of TLR2, TLR4 and CD14 Genetic Polymorphisms in Gastric Carcinogenesis: A Case-Control Study and Meta-Analysis

CYP2E1 RsaI/PstI Polymorphism and Gastric Cancer Susceptibility: Meta-Analyses Based on 24 Case-Control Studies

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