CYP2E1 RsaI/PstI Polymorphism and Gastric Cancer Susceptibility: Meta-Analyses Based on 24 Case-Control Studies

Abstract

BackgroundPrevious reports implicate CYP2E1 RsaI/PstI polymorphism as a possible risk factor for several cancers. Published studies on the relationship of CYP2E1 RsaI/PstI polymorphisms with the susceptibility to gastric cancer are controversial. This study aimed to determine this relationship accurately.MethodsMeta-analyses that assessed the association of CYP2E1 RsaI/PstI variations with gastric cancer were conducted. Subgroup analyses on ethnicity, smoking status, alcohol consumption, and source of controls were also performed. Eligible studies up to Mar 2012 were identified.ResultsAfter rigorous searching and screening, 24 case-control studies comprising 3022 cases and 4635 controls were selected for analysis. The overall data failed to indicate the significant associations of CYP2E1 RsaI/PstI polymorphisms with the gastric cancer risk [c2 vs. c1: odds ratio (OR) = 1.06; 95% confidence interval (CI) = 0.88–1.28; c2c2 vs. c1c1: OR = 1.23; 95% CI = 0.78–1.92; c2c2+c1c2 vs. c1c1: OR = 0.93; 95% CI = 0.79–1.10]. Similar results were observed in the subgroup analyses on ethnicity, drinking status, and source of controls. However, in the subgroup analysis on smoking status, a borderline increase in cancer risk was found among long-term smokers (c2c2+c1c2 vs. c1c1: OR = 1.39; 95% CI = 1.00–1.92).ConclusionCYP2E1 RsaI/PstI polymorphisms may modify the susceptibility to gastric cancer among individuals who have a smoking history. Large and well-designed studies are needed to confirm this conclusion.

Cytochrome P450 in Cancer Susceptibility and Treatment

“…Results were confirmed by meta-analysis which concluded that CYP2E1-PstI/RsaI polymorphism may be a risk factor for gastric cancer in Asians [197]. However, a recent meta-analysis study did not find any significant association of CYP2E1 RsaI/PstI polymorphisms with gastric cancer risk [202].…”

CYP2E1 Genetic Polymorphism with Dietary, Tobacco, Alcohol Habits, H. pylori Infection Status and Susceptibility to Stomach Cancer in Mizoram, India

“…In another study, Kato et al, (2011) reported that CYP2E1 RsaI polymorphisms do not influence the development of primary stomach cancer, but may do so in specific conditions, such as the remnant stomach after gastrectomy. In a meta-analysis, Zhuo et al, (2012) did not find any significant associations of CYP2E1 RsaI/PstI polymorphisms with the gastric cancer risk. Masuda et al, (2007) reported that gastric cancer in patients younger than 40 years is closely associated with H. pylori infection, but not with genetic polymorphism of CYP2E1.…”

“…Few studies revealed a positive association between CYP2E1 RsaI polymorphism and stomach cancer risk Boccia et al, 2007). Some other studies found no risk association of CYP2E1 polymorphism and stomach cancer (Kato et al, 1995;Nishimoto et al, 2000;Park et al, 2003;Darazy et al, 2011;Zhuo et al, 2012). We have undertaken this study, as there is no report available so far from this region, which examines the association of CYP2E1 polymorphism and stomach cancer risk considering various dietary, tobacco and alcohol habits, enabling also the study of the relationship between environment and CYP2E1 gene RsaI polymorphism in terms of stomach cancer risk in Mizoram.…”

“…Both current and past Meiziol & cigarette together smokers who smoke for more than 10 times per day and carrying the (C/C) genotype demonstrated significantly increased risk of stomach cancer in our study. Zhuo et al, (2012) in a metaanalysis reported that CYP2E1 RsaI/PstI polymorphisms may modify the susceptibility to gastric cancer among individuals who have a smoking history.…”

Association between CYP2E1 polymorphisms and risk of gastric cancer: An updated meta-analysis of 32 case-control studies

“…In the interaction analysis, C2 in RsaI/PstI was revealed to increase GC risk when the DraI was not mutated. The present study obtained two meta-analyses focusing on the association between RsaI/PstI polymorphisms and GC susceptibility (20,51). It was demonstrated that RsaI/PstI polymorphisms increased GC risk in the smoking population; however, no focus on the DraI polymorphisms or the interactions between two polymorphisms was provided.…”